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LOC106903146 origin of replication upstream of MCM4 [ Homo sapiens (human) ]

Gene ID: 106903146, updated on 10-Oct-2023

Summary

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Gene symbol
LOC106903146
Gene description
origin of replication upstream of MCM4
Gene type
biological region
Feature type(s)
protein_bind
rep_origin
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region contains an origin of DNA replication overlapping with the promoters of MCM4 (minichromosome maintenance complex component 4) and PRKDC (protein kinase, DNA-activated, catalytic polypeptide). This sequence binds Ets2 (v-ets avian erythroblastosis virus E26 oncogene homolog 2), which promotes association of other replication factors. Binding by Ets1 (v-ets avian erythroblastosis virus E26 oncogene homolog 1) may suppress origin activity. [provided by RefSeq, Jan 2016]
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Genomic context

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See LOC106903146 in Genome Data Viewer
Location:
8q11.2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (47960160..47960795)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (48336408..48337043)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (48872720..48873355)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:48649750-48650688 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19173 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19174 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:48664855-48665355 Neighboring gene CCAAT enhancer binding protein delta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27329 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:48678117-48678684 Neighboring gene protein kinase, DNA-activated, catalytic subunit Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:48734487-48735248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:48737843-48738343 Neighboring gene Sharpr-MPRA regulatory region 7649 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:48770411-48770910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27330 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:48836071-48836571 Neighboring gene uncharacterized LOC105375818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:48867403-48867904 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27331 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19176 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19177 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19179 Neighboring gene RNA, U6 small nuclear 519, pseudogene Neighboring gene minichromosome maintenance complex component 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteins of the origin recognition complex (ORC) and DNA topoisomerases on mammalian chromatin. Hu HG, et al. BMC Mol Biol, 2009 Apr 28. PMID 19397829, Free PMC Article
  2. Genome-wide mapping of human DNA-replication origins: levels of transcription at ORC1 sites regulate origin selection and replication timing. Dellino GI, et al. Genome Res, 2013 Jan. PMID 23187890, Free PMC Article
  3. c-ETS transcription factors play an essential role in the licensing of human MCM4 origin of replication. Sidhu K, et al. Biochim Biophys Acta, 2015 Nov. PMID 26365772
  4. Identification of new human origins of DNA replication by an origin-trapping assay. Gerhardt J, et al. Mol Cell Biol, 2006 Oct. PMID 16954389, Free PMC Article
  5. Identification of a binding region for human origin recognition complex proteins 1 and 2 that coincides with an origin of DNA replication. Ladenburger EM, et al. Mol Cell Biol, 2002 Feb. PMID 11809796, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046334.2 

    Range
    101..736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    47960160..47960795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    48336408..48337043
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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