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NSD2 nuclear receptor binding SET domain protein 2 [ Calidris pugnax (ruff) ]

Gene ID: 106902931, updated on 3-Aug-2024

Summary

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Gene symbol
NSD2
Gene description
nuclear receptor binding SET domain protein 2
See related
Ensembl:ENSCPUG00000007578
Gene type
protein coding
RefSeq status
MODEL
Organism
Calidris pugnax
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Neoaves; Charadriiformes; Scolopacidae; Calidris
Also known as
WHSC1
Orthologs
human mouse all
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Genomic context

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See NSD2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
23
Annotation release Status Assembly Chr Location
100 current ASM143184v1 (GCF_001431845.1) Unplaced Scaffold NW_015090793.1 (6657906..6761849, complement)

NW_015090793.1Genomic Context describing neighboring genes Neighboring gene multiple epidermal growth factor-like domains protein 9 Neighboring gene negative elongation factor complex member A Neighboring gene uncharacterized LOC106902933 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 1 Neighboring gene fibroblast growth factor receptor 3 Neighboring gene transforming acidic coiled-coil containing protein 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_015090793.1 Unplaced Scaffold Reference ASM143184v1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables histone H3K36 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of chromatin IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase NSD2
Names
Wolf-Hirschhorn syndrome candidate 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Calidris pugnax Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM143184v1

Genomic

  1. NW_015090793.1 Reference ASM143184v1

    Range
    6657906..6761849 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014966772.1 → XP_014822258.1  histone-lysine N-methyltransferase NSD2 isoform X3

    Related
    ENSCPUP00000010665.1, ENSCPUT00000012733.1
    Conserved Domains (10) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:839 → 933
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:973 → 1023
    AWS; associated with SET domains
    smart00317
    Location:1024 → 1147
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    cd00084
    Location:462 → 511
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:677 → 723
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:724 → 777
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:794 → 834
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1202 → 1244
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cl22851
    Location:630 → 672
    PHD_SF; PHD finger superfamily

  2. XM_014966771.1 → XP_014822257.1  histone-lysine N-methyltransferase NSD2 isoform X2

    Related
    ENSCPUP00000010671.1, ENSCPUT00000012739.1
    Conserved Domains (9) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:848 → 942
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:982 → 1032
    AWS; associated with SET domains
    smart00317
    Location:1033 → 1156
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG5034
    Location:575 → 740
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd00084
    Location:462 → 511
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:746 → 792
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1211 → 1253
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cl22851
    Location:808 → 843
    PHD_SF; PHD finger superfamily

  3. XM_014966770.1 → XP_014822256.1  histone-lysine N-methyltransferase NSD2 isoform X1

    Related
    ENSCPUP00000010660.1, ENSCPUT00000012728.1
    Conserved Domains (11) summary
    cd05837
    Location:219 → 338
    MSH6_like; The PWWP domain is present in MSH6, a mismatch repair protein homologous to bacterial MutS. The PWWP domain of histone-lysine N-methyltransferase, also known as Nuclear SET domain-containing protein 3, is also included. Mutations in MSH6 have been ...
    cd05838
    Location:908 → 1002
    WHSC1_related; The PWWP domain was first identified in the WHSC1 (Wolf-Hirschhorn syndrome candidate 1) protein, a protein implicated in Wolf-Hirschhorn syndrome (WHS). When translocated, WHSC1 plays a role in lymphoid multiple myeloma (MM) disease, also known as ...
    smart00570
    Location:1042 → 1092
    AWS; associated with SET domains
    smart00317
    Location:1093 → 1216
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    COG5034
    Location:575 → 740
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd00084
    Location:462 → 511
    HMG-box; High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I ...
    cd15651
    Location:746 → 792
    PHD2_NSD2; PHD finger 2 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15654
    Location:793 → 846
    PHD3_NSD2; PHD finger 3 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15657
    Location:863 → 903
    PHD4_NSD2; PHD finger 4 found in nuclear SET domain-containing protein 2 (NSD2)
    cd15660
    Location:1271 → 1313
    PHD5_NSD2; PHD finger 5 found in nuclear SET domain-containing protein 2 (NSD2)
    cl22851
    Location:699 → 741
    PHD_SF; PHD finger superfamily

RNA

  1. XR_001414619.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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