U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

LOC106867047 origin of replication upstream of MYC [ Homo sapiens (human) ]

Gene ID: 106867047, updated on 16-Mar-2024

Summary

Go to the top of the page Help
Gene symbol
LOC106867047
Gene description
origin of replication upstream of MYC
Gene type
biological region
Feature type(s)
protein_bind
regulatory: DNase_I_hypersensitive_site, replication_regulatory_region
rep_origin
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This region contains multiple sequences that can function as replication origins. These origins show activity in the endogenous context, in ectopic locations, and on plasmids. Binding of D-tyrosyl-tRNA deacylase 1 (Dtd1) to an element known as the DUE (DNA unwinding element) results in recruitment of members of the origin recognition complex as well as associated replication factors, leading to initiation of DNA synthesis. This region contains multiple DNase I hypersensitive sites and sequences that may adopt non-canonical structures. However, unlike some mammalian origins, this sequence is not significantly methylated. Multiple promoters of the MYC (v-myc avian myelocytomatosis viral oncogene homolog) gene are also located in this vicinity; transcription in this region may interfere with replication origin activity. [provided by RefSeq, Jan 2016]
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
8q24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (127733744..127736141)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (128861196..128863595)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (128745990..128748387)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene cancer susceptibility 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27941 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:128444461-128445375 Neighboring gene POU class 5 homeobox 1B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27942 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27943 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27944 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27945 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19528 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:128620950-128621545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27946 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:128658093-128658594 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:128658595-128659094 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:128672691-128673890 Neighboring gene uncharacterized LOC105375754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128681305-128681805 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128717643-128718143 Neighboring gene NANOG hESC enhancer GRCh37_chr8:128744882-128745383 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19530 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:128754894-128756093 Neighboring gene cancer susceptibility 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128805180-128805750 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19531 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19532 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19533 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128806893-128807462 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128807463-128808034 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19534 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:128816065-128816704 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128815423-128816064 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128814781-128815422 Neighboring gene Sharpr-MPRA regulatory region 14038 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128821670-128822570 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128822571-128823470 Neighboring gene Sharpr-MPRA regulatory region 15510 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128830247-128830786 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128832947-128833486 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr8:128834567-128835106 Neighboring gene MYC proto-oncogene, bHLH transcription factor Neighboring gene ReSE screen-validated silencer GRCh37_chr8:128858753-128858938 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128862019-128862636 Neighboring gene microRNA 1204 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128864303-128865152 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:128866418-128867617 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128879341-128879948 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128888845-128889392 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:128891961-128892128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128893083-128893582 Neighboring gene Pvt1 oncogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27951 Neighboring gene Sharpr-MPRA regulatory region 1737 Neighboring gene CRISPRi-validated MYC e1 enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128913423-128914077 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128916503-128917004 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128920055-128920986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128920987-128921919 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:128923753-128924342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27953 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128932048-128932575 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:128936915-128937414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:128951647-128952169 Neighboring gene long intergenic non-protein coding RNA 2912

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Activation of a human chromosomal replication origin by protein tethering. Chen X, et al. Nucleic Acids Res, 2013 Jul. PMID 23658226, Free PMC Article
  2. Dissection of mammalian replicators by a novel plasmid stability assay. Hashizume T, et al. J Cell Biochem, 2007 Jun 1. PMID 17226771
  3. Site-specific loading of an MCM protein complex in a DNA replication initiation zone upstream of the c-MYC gene in the HeLa cell cycle. Kinoshita Y, et al. J Biol Chem, 2004 Aug 20. PMID 15190069
  4. Multiple functional elements comprise a Mammalian chromosomal replicator. Liu G, et al. Mol Cell Biol, 2003 Mar. PMID 12589000, Free PMC Article
  5. Immortalization of human WI38 cells is associated with differential activation of the c-myc origins. Tao L, et al. J Cell Biochem, 2001. PMID 11500928

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See Variation Viewer (GRCh37.p13)

General gene information

Go to the top of the page Help

Homology

Other Names

  • c-myc origin of replication

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046332.1 

    Range
    101..2498
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    127733744..127736141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    128861196..128863595
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases