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LOC106804547 origin of replication adjacent to lamin B2 [ Homo sapiens (human) ]

Gene ID: 106804547, updated on 10-Oct-2023

Summary

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Gene symbol
LOC106804547
Gene description
origin of replication adjacent to lamin B2
Gene type
biological region
Feature type(s)
misc_feature: nucleotide_cleavage_site, replication_start_site
protein_bind
regulatory: DNase_I_hypersensitive_site, replication_regulatory_region
rep_origin
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This record represents a DNase I hypersensitive region that contains an early-firing bidirectional origin of DNA replication. Various replication factors, DNA helicases, and other chromatin-associated proteins are recruited to the core origin sequence during G1 and S phase, disassociating as the cell cycle progresses. These proteins include origin recognition complex subunits 2, 3, 4, and 6; X-ray repair complementing defective repair in Chinese hamster cells 5 and 6; cell division cycle 6; homeobox C10 and C13; and topoisomerase (DNA) I and II. Binding by v-myc avian myelocytomatosis viral oncogene homolog may be important for recruiting minichromosome maintenance complex components and promoting chromatin changes in this region. This sequence can function as an origin of replication in a transgene moved to an ectopic context. [provided by RefSeq, Dec 2015]
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Genomic context

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See LOC106804547 in Genome Data Viewer
Location:
19p13.3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (2426874..2428373)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (2402665..2404164)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2426872..2428371)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:2328300-2328954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13683 Neighboring gene signal peptide peptidase like 2B Neighboring gene ReSE screen-validated silencer GRCh37_chr19:2358582-2358793 Neighboring gene transmembrane serine protease 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2376438-2376950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13684 Neighboring gene uncharacterized LOC124904612 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2426331-2427074 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2427075-2427820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13685 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2433582-2434270 Neighboring gene translocase of inner mitochondrial membrane 13 Neighboring gene lamin B2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2441143-2441644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2441645-2442144 Neighboring gene microRNA 7108 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2452980-2453594 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:2453595-2454209 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2454266-2454976 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:2454977-2455685 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9790 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9791 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9792 Neighboring gene long intergenic non-protein coding RNA 1775

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNA-protein interaction dynamics at the Lamin B2 replication origin. Puzzi L, et al. Cell Cycle, 2015. PMID 25483070, Free PMC Article
  2. Ku protein levels, localization and association to replication origins in different stages of breast tumor progression. Abdelbaqi K, et al. J Cancer, 2013. PMID 23781282, Free PMC Article
  3. Origin of DNA replication at the human lamin B2 locus: OBR or ABR? Lee H, et al. Cell Cycle, 2012 Nov 15. PMID 22983127, Free PMC Article
  4. The epigenetic control of E-box and Myc-dependent chromatin modifications regulate the licensing of lamin B2 origin during cell cycle. Swarnalatha M, et al. Nucleic Acids Res, 2012 Oct. PMID 22772991, Free PMC Article
  5. Homeotic proteins participate in the function of human-DNA replication origins. Marchetti L, et al. Nucleic Acids Res, 2010 Dec. PMID 20693533, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_046167.1 

    Range
    101..1600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    2426874..2428373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    2402665..2404164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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