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Dhx57 DExH-box helicase 57 [ Mus musculus (house mouse) ]

Gene ID: 106794, updated on 28-Oct-2024

Summary

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Official Symbol
Dhx57provided by MGI
Official Full Name
DExH-box helicase 57provided by MGI
Primary source
MGI:MGI:2147067
See related
Ensembl:ENSMUSG00000035051 AllianceGenome:MGI:2147067
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable RNA binding activity and helicase activity. Is expressed in central nervous system and retina. Orthologous to human DHX57 (DExH-box helicase 57). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in CNS E18 (RPKM 21.0), CNS E14 (RPKM 17.1) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Dhx57 in Genome Data Viewer
Location:
17 E3; 17 50.63 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (80545733..80597620, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (80238304..80290476, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3216 Neighboring gene STARR-positive B cell enhancer ABC_E7559 Neighboring gene serine and arginine-rich splicing factor 7 Neighboring gene STARR-positive B cell enhancer ABC_E5631 Neighboring gene gem nuclear organelle associated protein 6 Neighboring gene tetratricopeptide repeat domain 39D Neighboring gene STARR-positive B cell enhancer ABC_E3217 Neighboring gene STARR-positive B cell enhancer ABC_E5632 Neighboring gene STARR-seq mESC enhancer starr_43307 Neighboring gene STARR-seq mESC enhancer starr_43308 Neighboring gene STARR-positive B cell enhancer ABC_E7560 Neighboring gene MORN repeat containing 2 Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene STARR-seq mESC enhancer starr_43309 Neighboring gene STARR-seq mESC enhancer starr_43310 Neighboring gene predicted gene 10190

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article
  2. Proteomic and yeast 2-hybrid screens to identify PTEN binding partners. Tibarewal P, et al. Adv Biol Regul, 2024 Jan. PMID 37839992
  3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  4. Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics. Federspiel JD, et al. Mol Cell Proteomics, 2019 Aug 9. PMID 31040226, Free PMC Article
  5. KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility. Gu J, et al. Cell Death Differ, 2023 Jul. PMID 37142655, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC77974

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative ATP-dependent RNA helicase DHX57
Names
DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 homolog
DEAH box protein 57
NP_001157231.1
NP_001397255.1
NP_001397256.1
NP_001397257.1
NP_945180.2
XP_030105293.1
XP_030105294.1
XP_030105295.1
XP_030105296.1
XP_030105297.1
XP_036016147.1
XP_036016148.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163759.2 → NP_001157231.1  putative ATP-dependent RNA helicase DHX57 isoform 1

    See identical proteins and their annotated locations for NP_001157231.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC132910
    Consensus CDS
    CCDS50188.1
    UniProtKB/Swiss-Prot
    Q3TS93, Q6NZK4, Q6P1B4, Q6P5D3, Q8BI63, Q8BIA2, Q8R360
    Related
    ENSMUSP00000083742.4, ENSMUST00000086555.11
    Conserved Domains (3) summary
    COG1643
    Location:501 → 1298
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd14317
    Location:181 → 218
    UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
    pfam05773
    Location:246 → 419
    RWD; RWD domain

  2. NM_001410326.1 → NP_001397255.1  putative ATP-dependent RNA helicase DHX57 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC132910
    UniProtKB/Swiss-Prot
    Q3TS93, Q6NZK4, Q6P1B4, Q6P5D3, Q8BI63, Q8BIA2, Q8R360

  3. NM_001410327.1 → NP_001397256.1  putative ATP-dependent RNA helicase DHX57 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC132910

  4. NM_001410328.1 → NP_001397257.1  putative ATP-dependent RNA helicase DHX57 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC132910

  5. NM_198942.3 → NP_945180.2  putative ATP-dependent RNA helicase DHX57 isoform 2

    See identical proteins and their annotated locations for NP_945180.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC132910
    Consensus CDS
    CCDS28990.1
    UniProtKB/Swiss-Prot
    Q6P5D3
    Related
    ENSMUSP00000041069.8, ENSMUST00000038166.9
    Conserved Domains (3) summary
    COG1643
    Location:448 → 1245
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd14317
    Location:128 → 165
    UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
    pfam05773
    Location:193 → 366
    RWD; RWD domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    80545733..80597620 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160255.1 → XP_036016148.1  putative ATP-dependent RNA helicase DHX57 isoform X7

    Conserved Domains (1) summary
    COG1643
    Location:82 → 548
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

  2. XM_030249437.2 → XP_030105297.1  putative ATP-dependent RNA helicase DHX57 isoform X6

    Conserved Domains (1) summary
    COG1643
    Location:11 → 771
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

  3. XM_030249433.2 → XP_030105293.1  putative ATP-dependent RNA helicase DHX57 isoform X3

    Conserved Domains (3) summary
    COG1643
    Location:432 → 1229
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd14317
    Location:112 → 149
    UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
    pfam05773
    Location:177 → 350
    RWD; RWD domain

  4. XM_030249436.1 → XP_030105296.1  putative ATP-dependent RNA helicase DHX57 isoform X4

    Conserved Domains (2) summary
    COG1643
    Location:272 → 1069
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam05773
    Location:17 → 190
    RWD; RWD domain

  5. XM_030249435.2 → XP_030105295.1  putative ATP-dependent RNA helicase DHX57 isoform X4

    Conserved Domains (2) summary
    COG1643
    Location:272 → 1069
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    pfam05773
    Location:17 → 190
    RWD; RWD domain

  6. XM_030249434.2 → XP_030105294.1  putative ATP-dependent RNA helicase DHX57 isoform X3

    Conserved Domains (3) summary
    COG1643
    Location:432 → 1229
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd14317
    Location:112 → 149
    UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
    pfam05773
    Location:177 → 350
    RWD; RWD domain

  7. XM_036160254.1 → XP_036016147.1  putative ATP-dependent RNA helicase DHX57 isoform X5

    Related
    ENSMUST00000234733.2
    Conserved Domains (4) summary
    COG1643
    Location:501 → 1008
    HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]
    cd14317
    Location:181 → 218
    UBA_DHX57; UBA domain found in putative ATP-dependent RNA helicase DHX57 and similar proteins
    pfam05773
    Location:246 → 419
    RWD; RWD domain
    pfam18345
    Location:305 → 323
    zf_CCCH_4; Zinc finger domain

RNA

  1. XR_003952074.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P5D3.2 GenPept UniProtKB/Swiss-Prot:Q6P5D3

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