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Fam234a family with sequence similarity 234, member A [ Mus musculus (house mouse) ]

Gene ID: 106581, updated on 2-Nov-2024

Summary

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Official Symbol
Fam234aprovided by MGI
Official Full Name
family with sequence similarity 234, member Aprovided by MGI
Primary source
MGI:MGI:2146854
See related
Ensembl:ENSMUSG00000024187 AllianceGenome:MGI:2146854
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Itfg3
Summary
Predicted to be located in membrane. Predicted to be active in cell surface. Is expressed in midgut and pancreas. Orthologous to human FAM234A (family with sequence similarity 234 member A). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in duodenum adult (RPKM 177.2), small intestine adult (RPKM 108.1) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Fam234a in Genome Data Viewer
Location:
17 A3.3; 17 13.07 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (26431673..26463216, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (26212692..26244307, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene Rho GDP dissociation inhibitor gamma Neighboring gene regulator of G-protein signaling 11 Neighboring gene predicted gene, 23123 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene Neighboring gene elongin-C-like Neighboring gene STARR-seq mESC enhancer starr_42121 Neighboring gene STARR-positive B cell enhancer ABC_E5581 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:26389741-26389850 Neighboring gene Luc7-like Neighboring gene poly(A) binding protein, cytoplasmic 1 pseudogene Neighboring gene hemoglobin alpha, pseudogene 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. In vivo and in vitro investigations of heterozygous nebulin knock-out mice disclose a mild skeletal muscle phenotype. Gineste C, et al. Neuromuscul Disord, 2013 Apr. PMID 23375831
  2. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IEA
Inferred from Electronic Annotation
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein FAM234A
Names
protein ITFG3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001206335.2 → NP_001193264.1  protein FAM234A isoform 1

    See identical proteins and their annotated locations for NP_001193264.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1-3 and 5-7 all encode the same isoform (1).
    Source sequence(s)
    AC126438
    Consensus CDS
    CCDS37512.1
    UniProtKB/Swiss-Prot
    Q3TZ74, Q8C0Z1
    Related
    ENSMUSP00000110639.2, ENSMUST00000114988.8
    Conserved Domains (1) summary
    pfam13360
    Location:130 → 250
    PQQ_2; PQQ-like domain

  2. NM_001357894.2 → NP_001344823.1  protein FAM234A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126438
    Consensus CDS
    CCDS37512.1
    UniProtKB/Swiss-Prot
    Q3TZ74, Q8C0Z1
    Related
    ENSMUSP00000157219.2, ENSMUST00000234687.2

  3. NM_001374603.1 → NP_001361532.1  protein FAM234A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126438
    UniProtKB/TrEMBL
    F6SQM4

  4. NM_001400249.1 → NP_001387178.1  protein FAM234A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126438
    UniProtKB/Swiss-Prot
    Q3TZ74, Q8C0Z1
    Related
    ENSMUSP00000157155.2, ENSMUST00000234262.2

  5. NM_001400250.1 → NP_001387179.1  protein FAM234A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126438
    UniProtKB/Swiss-Prot
    Q3TZ74, Q8C0Z1

  6. NM_001400251.1 → NP_001387180.1  protein FAM234A isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC126438
    UniProtKB/Swiss-Prot
    Q3TZ74, Q8C0Z1
    Related
    ENSMUSP00000157032.2, ENSMUST00000234175.2

  7. NM_001400252.1 → NP_001387181.1  protein FAM234A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126438
    UniProtKB/TrEMBL
    F6SQM4
    Related
    ENSMUSP00000115724.3, ENSMUST00000141240.3

  8. NM_001400253.1 → NP_001387182.1  protein FAM234A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126438
    UniProtKB/TrEMBL
    F6SQM4

  9. NM_001400254.1 → NP_001387183.1  protein FAM234A isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC126438
    UniProtKB/TrEMBL
    F6SQM4

  10. NM_001400255.1 → NP_001387184.1  protein FAM234A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC126438

  11. NM_001400256.1 → NP_001387185.1  protein FAM234A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC126438

  12. NM_207217.5 → NP_997100.1  protein FAM234A isoform 1

    See identical proteins and their annotated locations for NP_997100.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 and 5-7 all encode the same isoform (1).
    Source sequence(s)
    AC126438
    Consensus CDS
    CCDS37512.1
    UniProtKB/Swiss-Prot
    Q3TZ74, Q8C0Z1
    Related
    ENSMUSP00000113418.2, ENSMUST00000118487.8
    Conserved Domains (1) summary
    pfam13360
    Location:130 → 250
    PQQ_2; PQQ-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    26431673..26463216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246237.3 → XP_011244539.1  protein FAM234A isoform X1

    See identical proteins and their annotated locations for XP_011244539.1

    UniProtKB/Swiss-Prot
    Q3TZ74, Q8C0Z1
    Conserved Domains (1) summary
    pfam13360
    Location:130 → 250
    PQQ_2; PQQ-like domain

  2. XM_036160242.1 → XP_036016135.1  protein FAM234A isoform X1

    UniProtKB/Swiss-Prot
    Q3TZ74, Q8C0Z1
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C0Z1.1 GenPept UniProtKB/Swiss-Prot:Q8C0Z1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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