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rasa1.L RAS p21 protein activator (GTPase activating protein) 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 106557444, updated on 4-Nov-2024

Summary

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Official Symbol
rasa1.L
Official Full Name
RAS p21 protein activator (GTPase activating protein) 1 L homeolog
Primary source
Xenbase:XB-GENE-6085101
Locus tag
XELAEV_18008093mg
See related
EnsemblRapid:ENSXLAG00005005837 AllianceGenome:Xenbase:XB-GENE-6085101
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
rasa1
Summary
Predicted to enable GTPase activator activity. Human ortholog(s) of this gene implicated in arteriovenous malformation and basal cell carcinoma. Orthologous to human RASA1 (RAS p21 protein activator 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rasa1.L in Genome Data Viewer
Location:
chromosome: 1L
Exon count:
27
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (195589028..195646360, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (182448265..182506206, complement)

Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 161B Neighboring gene cyclin H L homeolog Neighboring gene small nucleolar RNA Z39 Neighboring gene cytochrome c oxidase subunit VIIc L homeolog Neighboring gene EGF like repeats and discoidin domains 3 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras GTPase-activating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    195589028..195646360 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041568560.1 → XP_041424494.1  ras GTPase-activating protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8J1L6C5, A0A974E231
    Conserved Domains (6) summary
    cd08400
    Location:488 → 613
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:58 → 161
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:247 → 323
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:178 → 236
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd05391
    Location:611 → 961
    RasGAP_p120GAP; Ras-GTPase Activating Domain of p120
    cd13260
    Location:370 → 473
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain

  2. XM_018264760.2 → XP_018120249.1  ras GTPase-activating protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8J0VDW8, A0A974E231
    Related
    ENSXLAP00005017430.1, ENSXLAT00005017726.1

  3. XM_041568565.1 → XP_041424499.1  ras GTPase-activating protein 1 isoform X5

    UniProtKB/TrEMBL
    A0A8J1L6D0, A0A974E231
    Conserved Domains (6) summary
    cd08400
    Location:488 → 613
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:58 → 161
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:247 → 323
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:178 → 236
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd13260
    Location:370 → 473
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
    cl02569
    Location:611 → 889
    RasGAP; Ras GTPase Activating Domain

  4. XM_041568556.1 → XP_041424490.1  ras GTPase-activating protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8J1L7B9, A0A974E231
    Related
    ENSXLAP00005017377.1, ENSXLAT00005017673.1
    Conserved Domains (6) summary
    cd08400
    Location:488 → 613
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:58 → 161
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:247 → 323
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:178 → 236
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd05391
    Location:611 → 934
    RasGAP_p120GAP; Ras-GTPase Activating Domain of p120
    cd13260
    Location:370 → 473
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain

  5. XM_041568567.1 → XP_041424501.1  ras GTPase-activating protein 1 isoform X6

    UniProtKB/TrEMBL
    A0A8J1L4M6
    Conserved Domains (5) summary
    cd08400
    Location:286 → 411
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10354
    Location:45 → 121
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd05391
    Location:409 → 732
    RasGAP_p120GAP; Ras-GTPase Activating Domain of p120
    cd13260
    Location:168 → 271
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
    cl17036
    Location:1 → 34
    SH3; Src Homology 3 domain superfamily

  6. XM_041568563.1 → XP_041424497.1  ras GTPase-activating protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8J1L4M3, A0A974E231
    Related
    ENSXLAP00005017443.1, ENSXLAT00005017739.1
    Conserved Domains (6) summary
    cd08400
    Location:488 → 613
    C2_Ras_p21A1; C2 domain present in RAS p21 protein activator 1 (RasA1)
    cd10353
    Location:58 → 161
    SH2_Nterm_RasGAP; N-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd10354
    Location:247 → 323
    SH2_Cterm_RasGAP; C-terminal Src homology 2 (SH2) domain found in Ras GTPase-activating protein 1 (GAP)
    cd11788
    Location:178 → 236
    SH3_RasGAP; Src Homology 3 domain of Ras GTPase-Activating Protein 1
    cd05391
    Location:611 → 915
    RasGAP_p120GAP; Ras-GTPase Activating Domain of p120
    cd13260
    Location:370 → 473
    PH_RASA1; RAS p21 protein activator (GTPase activating protein) 1 Pleckstrin homology (PH) domain
Nucleotide Protein Strain
Heading Accession and Version

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