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F12 coagulation factor XII [ Thamnophis sirtalis ]

Gene ID: 106553235, updated on 13-Mar-2024

Summary

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Gene symbol
F12
Gene description
coagulation factor XII
Gene type
protein coding
RefSeq status
MODEL
Organism
Thamnophis sirtalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Colubridae; Natricinae; Thamnophis
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See F12 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
12
Annotation release Status Assembly Chr Location
100 current Thamnophis_sirtalis-6.0 (GCF_001077635.1) Unplaced Scaffold NW_013659910.1 (14593..47142)

NW_013659910.1Genomic Context describing neighboring genes Neighboring gene P2Y purinoceptor 4-like Neighboring gene alpha-2Da adrenergic receptor-like Neighboring gene sodium-dependent phosphate transport protein 2A-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_013659910.1 Unplaced Scaffold Reference Thamnophis_sirtalis-6.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in blood coagulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in zymogen activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in rough endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
coagulation factor XII

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Thamnophis sirtalis Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Thamnophis_sirtalis-6.0

Genomic

  1. NW_013659910.1 Reference Thamnophis_sirtalis-6.0

    Range
    14593..47142
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014071699.1 → XP_013927174.1  coagulation factor XII

    UniProtKB/TrEMBL
    A0A6I9YT84
    Conserved Domains (6) summary
    smart00020
    Location:345 → 579
    Tryp_SPc; Trypsin-like serine protease
    smart00130
    Location:210 → 292
    KR; Kringle domain
    cd00054
    Location:94 → 125
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00190
    Location:346 → 582
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00008
    Location:173 → 202
    EGF; EGF-like domain
    pfam00040
    Location:42 → 83
    fn2; Fibronectin type II domain
Nucleotide Protein
Heading Accession and Version

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