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PAIP1 poly(A) binding protein interacting protein 1 [ Homo sapiens (human) ]

Gene ID: 10605, updated on 3-Nov-2024

Summary

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Official Symbol
PAIP1provided by HGNC
Official Full Name
poly(A) binding protein interacting protein 1provided by HGNC
Primary source
HGNC:HGNC:16945
See related
Ensembl:ENSG00000172239 MIM:605184; AllianceGenome:HGNC:16945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 24.5), thyroid (RPKM 20.8) and 25 other tissues See more
Orthologs
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Genomic context

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See PAIP1 in Genome Data Viewer
Location:
5p12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (43526267..43557411, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (43778980..43811059, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (43526369..43557513, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene C5orf34 antisense RNA 1 Neighboring gene chromosome 5 open reading frame 34 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 19 Neighboring gene uncharacterized LOC124900190 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22540 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:43521939-43522548 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15995 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:43580594-43581340 Neighboring gene NNT antisense RNA 1 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_85301 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:43602630-43602849 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15996 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15997 Neighboring gene adenosylmethionine decarboxylase 1 pseudogene 3 Neighboring gene nicotinamide nucleotide transhydrogenase Neighboring gene Sharpr-MPRA regulatory region 11344 Neighboring gene ribosomal protein L29 pseudogene 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Crystal structure of the middle domain of human poly(A)-binding protein-interacting protein 1. Lei J, et al. Biochem Biophys Res Commun, 2011 May 20. PMID 21539810
  2. High Paip1 Expression as a Potential Prognostic Marker in Hepatocellular Carcinoma. Kim H, et al. In Vivo, 2020 Sep-Oct. PMID 32871777, Free PMC Article
  3. Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis. Li N, et al. Cancer Res Treat, 2019 Oct. PMID 31010277, Free PMC Article
  4. Role of Paip1 on angiogenesis and invasion in pancreatic cancer. Guan H, et al. Exp Cell Res, 2019 Mar 15. PMID 30731074
  5. Paip1 affects breast cancer cell growth and represents a novel prognostic biomarker. Piao J, et al. Hum Pathol, 2018 Mar. PMID 29258905

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
    Title: YAP1-activated ZNF131 promotes hepatocellular carcinoma cell proliferation through transcriptional regulation of PAIP1.
  2. Effect of PAIP1 on the metastatic potential and prognostic significance in oral squamous cell carcinoma.
    Title: Effect of PAIP1 on the metastatic potential and prognostic significance in oral squamous cell carcinoma.
  3. High Paip1 Expression as a Potential Prognostic Marker in Hepatocellular Carcinoma.
    Title: High Paip1 Expression as a Potential Prognostic Marker in Hepatocellular Carcinoma.
  4. The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation.
    Title: The SARS-unique domain (SUD) of SARS-CoV and SARS-CoV-2 interacts with human Paip1 to enhance viral RNA translation.
  5. Paip1 contributes to Pancreatic cancer progression and appears to be a valid prognostic factor of PC
    Title: Role of Paip1 on angiogenesis and invasion in pancreatic cancer.
  6. Paip1 was overexpressed in cervical cancer (CC) samples and associated with the adverse outcomes in patients with CC. Its knockdown induced inhibition of cell growth, G2/M arrest and apoptosis in CC cells.
    Title: Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis.
  7. These results indicated that PAIP1 and PAIP2 participate in translation termination and are important regulators of readthrough at the premature termination codon.
    Title: Polyadenylate-binding protein-interacting proteins PAIP1 and PAIP2 affect translation termination.
  8. our study demonstrated that Paip1 promotes the growth of breast cancers and could be a prognostic biomarker and therapeutic target
    Title: Paip1 affects breast cancer cell growth and represents a novel prognostic biomarker.
  9. Results showed that mRNA and protein expression of PAIP1, a miRNA-340 target gene, were down-regulated in women with gestational diabetes.
    Title: Maternal whole blood cell miRNA-340 is elevated in gestational diabetes and inversely regulated by glucose and insulin.
  10. Data provide evidence that the stability of Paip1 can be regulated by ubiquitin-mediated degradation, thus highlighting the importance of WWP2 as a suppressor of translation.
    Title: Paip1, an effective stimulator of translation initiation, is targeted by WWP2 for ubiquitination and degradation.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of poly(A) binding protein interacting protein 1 (PAIP1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC12360

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables translation activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in CRD-mediated mRNA stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA stabilization TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation by host of viral process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytoplasmic translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_positive_effect viral translation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of mCRD-mediated mRNA stability complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
polyadenylate-binding protein-interacting protein 1
Names
PABC1-interacting protein 1
PABP-interacting protein 1
PAIP-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006451.5 → NP_006442.2  polyadenylate-binding protein-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_006442.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC114956, BC015937, DB089732
    Consensus CDS
    CCDS3947.1
    UniProtKB/Swiss-Prot
    A6NKV8, O60455, Q96B61, Q9BS63, Q9H074
    Related
    ENSP00000302768.3, ENST00000306846.8
    Conserved Domains (2) summary
    PRK14951
    Location:35 → 123
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    pfam02854
    Location:160 → 376
    MIF4G; MIF4G domain

  2. NM_182789.4 → NP_877590.1  polyadenylate-binding protein-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_877590.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment, compared to variant 1, resulting in a shorter protein (isoform 2) that has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC114956, AK308270, BC015937
    Consensus CDS
    CCDS47204.1
    UniProtKB/TrEMBL
    D6REB4
    Related
    ENSP00000387729.2, ENST00000436644.6
    Conserved Domains (2) summary
    pfam07145
    Location:45 → 61
    PAM2; Ataxin-2 C-terminal region
    pfam02854
    Location:81 → 297
    MIF4G; MIF4G domain

  3. NM_183323.3 → NP_899152.1  polyadenylate-binding protein-interacting protein 1 isoform 3

    See identical proteins and their annotated locations for NP_899152.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate exon, compared to variant 1, resulting in a different 5' UTR and use of a downstream in-frame start codon. Isoform 3 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC114956, BC015937, DB089732
    Consensus CDS
    CCDS3948.1
    UniProtKB/TrEMBL
    D6REB4
    Related
    ENSP00000339622.4, ENST00000338972.8
    Conserved Domains (2) summary
    pfam07145
    Location:12 → 28
    PAM2; Ataxin-2 C-terminal region
    pfam02854
    Location:48 → 264
    MIF4G; MIF4G domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    43526267..43557411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    43778980..43811059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H074.1 GenPept UniProtKB/Swiss-Prot:Q9H074

Gene LinkOut

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