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cbl Cbl proto-oncogene, E3 ubiquitin protein ligase [ Clupea harengus (Atlantic herring) ]

Gene ID: 105912771, updated on 18-Jun-2024

Summary

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Gene symbol
cbl
Gene description
Cbl proto-oncogene, E3 ubiquitin protein ligase
See related
Ensembl:ENSCHAG00020008005
Gene type
protein coding
RefSeq status
MODEL
Organism
Clupea harengus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Clupei; Clupeiformes; Clupeoidei; Clupeidae; Clupea
Orthologs
human zebrafish all
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Genomic context

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See cbl in Genome Data Viewer
Location:
chromosome: 17
Exon count:
16
Annotation release Status Assembly Chr Location
102 current Ch_v2.0.2 (GCF_900700415.2) 17 NC_045168.1 (15969781..16012287)

Chromosome 17 - NC_045168.1Genomic Context describing neighboring genes Neighboring gene glutamate receptor, ionotropic, kainate 4 Neighboring gene dynein regulatory complex subunit 12 homolog Neighboring gene melanoma cell adhesion molecule b Neighboring gene tetratricopeptide repeat protein 21B-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_045168.1 Chromosome 17 Reference Ch_v2.0.2 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Clupea harengus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Ch_v2.0.2 Primary Assembly

Genomic

  1. NC_045168.1 Reference Ch_v2.0.2 Primary Assembly

    Range
    15969781..16012287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_031583831.2 → XP_031439691.1  E3 ubiquitin-protein ligase CBL isoform X1

    UniProtKB/TrEMBL
    A0A6P8GPI5
    Related
    ENSCHAP00020017056.1, ENSCHAT00020018274.1
    Conserved Domains (5) summary
    cd09920
    Location:240 → 336
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14393
    Location:912 → 951
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
    cd16709
    Location:346 → 411
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:38 → 156
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:163 → 246
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

  2. XM_031583832.2 → XP_031439692.1  E3 ubiquitin-protein ligase CBL isoform X2

    UniProtKB/TrEMBL
    A0A6P8GVZ1
    Related
    ENSCHAP00020017040.1, ENSCHAT00020018258.1
    Conserved Domains (5) summary
    cd09920
    Location:240 → 336
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd14393
    Location:891 → 930
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
    cd16709
    Location:346 → 411
    RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
    pfam02262
    Location:38 → 156
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:163 → 246
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
Nucleotide Protein
Heading Accession and Version

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