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PKLR pyruvate kinase L/R [ Microcebus murinus (gray mouse lemur) ]

Gene ID: 105873168, updated on 13-Mar-2024

Summary

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Gene symbol
PKLR
Gene description
pyruvate kinase L/R
See related
Ensembl:ENSMICG00000007458
Gene type
protein coding
RefSeq status
MODEL
Organism
Microcebus murinus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes; Cheirogaleidae; Microcebus
Orthologs
human mouse all
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Genomic context

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See PKLR in Genome Data Viewer
Location:
chromosome: 2
Exon count:
12
Annotation release Status Assembly Chr Location
101 current Mmur_3.0 (GCF_000165445.2) 2 NC_033661.1 (121362785..121372403)
100 previous assembly Mmur_2.0 (GCF_000165445.1) Unplaced Scaffold NW_012196131.1 (2043739..2054207)

Chromosome 2 - NC_033661.1Genomic Context describing neighboring genes Neighboring gene RUN and SH3 domain containing 1 Neighboring gene RUSC1 antisense RNA 1 Neighboring gene farnesyl diphosphate synthase Neighboring gene hyperpolarization activated cyclic nucleotide gated potassium channel 3 Neighboring gene CDC like kinase 2 Neighboring gene uncharacterized LOC105873171

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables potassium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyruvate kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pyruvate kinase PKLR
Names
pyruvate kinase, liver and RBC

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Microcebus murinus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmur_3.0 Primary Assembly

Genomic

  1. NC_033661.1 Reference Mmur_3.0 Primary Assembly

    Range
    121362785..121372403
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012767831.2 → XP_012623285.1  pyruvate kinase PKLR isoform X1

    UniProtKB/TrEMBL
    A0A8B7GK09
    Related
    ENSMICP00000048101.1, ENSMICT00000071039.1
    Conserved Domains (2) summary
    cd00288
    Location:85 → 573
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:86 → 570
    pyruv_kin; pyruvate kinase

  2. XM_012767832.2 → XP_012623286.1  pyruvate kinase PKLR isoform X2

    UniProtKB/TrEMBL
    A0A8B7GK10
    Related
    ENSMICP00000006784.2, ENSMICT00000007455.3
    Conserved Domains (2) summary
    cd00288
    Location:54 → 542
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:55 → 539
    pyruv_kin; pyruvate kinase

  3. XM_012767833.2 → XP_012623287.1  pyruvate kinase PKLR isoform X3

    UniProtKB/TrEMBL
    A0A8B7GKC1
    Conserved Domains (2) summary
    cd00288
    Location:21 → 509
    Pyruvate_Kinase; Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low ...
    TIGR01064
    Location:22 → 506
    pyruv_kin; pyruvate kinase
Nucleotide Protein
Heading Accession and Version

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