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PLCE1 phospholipase C epsilon 1 [ Microcebus murinus (gray mouse lemur) ]

Gene ID: 105872349, updated on 13-Mar-2024

Summary

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Gene symbol
PLCE1
Gene description
phospholipase C epsilon 1
See related
Ensembl:ENSMICG00000005545
Gene type
protein coding
RefSeq status
MODEL
Organism
Microcebus murinus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes; Cheirogaleidae; Microcebus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
36
Annotation release Status Assembly Chr Location
101 current Mmur_3.0 (GCF_000165445.2) 15 NC_033674.1 (44942474..45232390)
100 previous assembly Mmur_2.0 (GCF_000165445.1) Unplaced Scaffold NW_012195042.1 (4475476..4765258)

Chromosome 15 - NC_033674.1Genomic Context describing neighboring genes Neighboring gene N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2-like Neighboring gene coiled-coil-helix-coiled-coil-helix domain-containing protein 2 pseudogene Neighboring gene NOC3 like DNA replication regulator Neighboring gene TBC1 domain family member 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Microcebus murinus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmur_3.0 Primary Assembly

Genomic

  1. NC_033674.1 Reference Mmur_3.0 Primary Assembly

    Range
    44942474..45232390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012766286.2 → XP_012621740.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

    UniProtKB/TrEMBL
    A0A8B7GGZ5
    Conserved Domains (6) summary
    cd00275
    Location:1885 → 1997
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd01780
    Location:2150 → 2249
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1391 → 1846
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:1317 → 1996
    PLN02952; phosphoinositide phospholipase C
    pfam00617
    Location:533 → 712
    RasGEF; RasGEF domain
    pfam09279
    Location:1327 → 1378
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  2. XM_012766279.2 → XP_012621733.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    UniProtKB/TrEMBL
    A0A8B7GG51
    Conserved Domains (6) summary
    cd00275
    Location:1885 → 1997
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd01780
    Location:2150 → 2249
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1391 → 1846
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:1317 → 1996
    PLN02952; phosphoinositide phospholipase C
    pfam00617
    Location:533 → 712
    RasGEF; RasGEF domain
    pfam09279
    Location:1327 → 1378
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  3. XM_012766304.2 → XP_012621758.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

    UniProtKB/TrEMBL
    A0A8B7GG77
    Conserved Domains (6) summary
    cd00275
    Location:1869 → 1981
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd01780
    Location:2134 → 2233
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1375 → 1830
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:1301 → 1980
    PLN02952; phosphoinositide phospholipase C
    pfam00617
    Location:533 → 712
    RasGEF; RasGEF domain
    pfam09279
    Location:1311 → 1362
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  4. XM_012766294.2 → XP_012621748.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

    See identical proteins and their annotated locations for XP_012621748.1

    UniProtKB/TrEMBL
    A0A8C5UQM7, A0A8C5XNL6
    Related
    ENSMICP00000005065.3, ENSMICT00000005553.3
    Conserved Domains (6) summary
    cd00275
    Location:1871 → 1983
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd01780
    Location:2136 → 2235
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1391 → 1832
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:1317 → 1982
    PLN02952; phosphoinositide phospholipase C
    pfam00617
    Location:533 → 712
    RasGEF; RasGEF domain
    pfam09279
    Location:1327 → 1378
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  5. XM_012766309.2 → XP_012621763.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

    UniProtKB/TrEMBL
    A0A8B7GG69
    Conserved Domains (6) summary
    cd00275
    Location:1855 → 1967
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd01780
    Location:2120 → 2219
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1375 → 1816
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:1301 → 1966
    PLN02952; phosphoinositide phospholipase C
    pfam00617
    Location:533 → 712
    RasGEF; RasGEF domain
    pfam09279
    Location:1311 → 1362
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  6. XM_012766320.2 → XP_012621774.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X6

    UniProtKB/TrEMBL
    A0A8B7GGP0, A0A8C5XNL6
    Related
    ENSMICP00000038257.2, ENSMICT00000037399.2
    Conserved Domains (6) summary
    cd00275
    Location:1502 → 1614
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd01780
    Location:1767 → 1866
    PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
    cd08596
    Location:1008 → 1463
    PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
    PLN02952
    Location:934 → 1613
    PLN02952; phosphoinositide phospholipase C
    pfam00617
    Location:150 → 329
    RasGEF; RasGEF domain
    pfam09279
    Location:944 → 995
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

RNA

  1. XR_001154560.2 RNA Sequence

Nucleotide Protein
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