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PLCG2 phospholipase C gamma 2 [ Microcebus murinus (gray mouse lemur) ]

Gene ID: 105859475, updated on 13-Mar-2024

Summary

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Gene symbol
PLCG2
Gene description
phospholipase C gamma 2
See related
Ensembl:ENSMICG00000015143
Gene type
protein coding
RefSeq status
MODEL
Organism
Microcebus murinus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes; Cheirogaleidae; Microcebus
Orthologs
human mouse all
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Genomic context

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See PLCG2 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
30
Annotation release Status Assembly Chr Location
101 current Mmur_3.0 (GCF_000165445.2) 20 NC_033679.1 (7786485..7899810)
100 previous assembly Mmur_2.0 (GCF_000165445.1) Unplaced Scaffold NW_012200419.1 (1572973..1687426, complement)

Chromosome 20 - NC_033679.1Genomic Context describing neighboring genes Neighboring gene ATPase secretory pathway Ca2+ transporting 2 Neighboring gene WAP four-disulfide core domain 1 Neighboring gene uncharacterized LOC109729833 Neighboring gene heparan-alpha-glucosaminide N-acetyltransferase Neighboring gene protein O-mannose kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of epithelial cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Microcebus murinus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmur_3.0 Primary Assembly

Genomic

  1. NC_033679.1 Reference Mmur_3.0 Primary Assembly

    Range
    7786485..7899810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012743288.2 → XP_012598742.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

    UniProtKB/TrEMBL
    A0A8B7EU57, A0A8C5XK40
    Related
    ENSMICP00000030811.2, ENSMICT00000035406.2
    Conserved Domains (8) summary
    cd00275
    Location:999 → 1125
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08592
    Location:268 → 396
    PI-PLCc_gamma; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-gamma
    cd09932
    Location:579 → 682
    SH2_C-SH2_PLC_gamma_like; C-terminal Src homology 2 (C-SH2) domain in Phospholipase C gamma
    cd10341
    Location:465 → 565
    SH2_N-SH2_PLC_gamma_like; N-terminal Src homology 2 (N-SH2) domain in Phospholipase C gamma
    cd11969
    Location:711 → 765
    SH3_PLCgamma2; Src homology 3 domain of Phospholipase C (PLC) gamma 2
    cd13234
    Location:778 → 848
    PHsplit_PLC_gamma; Phospholipase C-gamma Split pleckstrin homology (PH) domain
    cl14615
    Location:864 → 969
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    cl17171
    Location:1 → 73
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version

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