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POMT1 protein O-mannosyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 10585, updated on 3-Apr-2024

Summary

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Official Symbol
POMT1provided by HGNC
Official Full Name
protein O-mannosyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:9202
See related
Ensembl:ENSG00000130714 MIM:607423; AllianceGenome:HGNC:9202
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RT; LGMD2K; MDDGA1; MDDGB1; MDDGC1; LGMDR11
Summary
The protein encoded by this gene is an O-mannosyltransferase that requires interaction with the product of the POMT2 gene for enzymatic function. The encoded protein is found in the membrane of the endoplasmic reticulum. Defects in this gene are a cause of Walker-Warburg syndrome (WWS) and limb-girdle muscular dystrophy type 2K (LGMD2K). Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
Expression
Broad expression in testis (RPKM 20.7), brain (RPKM 7.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
9q34.13
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (131502918..131523799)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (143715812..143736761)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (134378305..134399186)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene proline rich coiled-coil 2B Neighboring gene uncharacterized LOC124902290 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:134375403-134376602 Neighboring gene small nucleolar RNA, C/D box 62B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134378091-134378958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134378959-134379824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134388206-134388706 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:134388707-134389207 Neighboring gene uncharacterized LOC105376301 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:134403902-134405101 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:134405807-134406720 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20421 Neighboring gene uridine-cytidine kinase 1 Neighboring gene NANOG hESC enhancer GRCh37_chr9:134426802-134427303 Neighboring gene proline rich transmembrane protein 1B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1. Vuorela A, et al. Nat Commun, 2021 Apr 16. PMID 33863907, Free PMC Article
  2. Molecular genetics of the POMT1-related muscular dystrophy-dystroglycanopathies. Hu P, et al. Mutat Res Rev Mutat Res, 2018 Oct-Dec. PMID 30454682
  3. [Analysis of POMT1 gene mutation in a pedigree affected with congenital muscular dystrophy]. Chen C, et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2018 Feb 10. PMID 29419866
  4. Compound heterozygous POMT1 mutations in a Chinese family with autosomal recessive muscular dystrophy-dystroglycanopathy C1. Hu P, et al. J Cell Mol Med, 2017 Jul. PMID 28157257, Free PMC Article
  5. Analysis of phenotype, enzyme activity and genotype of Chinese patients with POMT1 mutation. Yang H, et al. J Hum Genet, 2016 Aug. PMID 27193224

See all (56) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. POMT1 and POMT2 gene mutations result in 2 cases of alpha-dystroglycanopathy.", trans "POMT1POMT22alpha-.
    Title: POMT1 and POMT2 gene mutations result in 2 cases of alpha-dystroglycanopathy.
  2. Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1.
    Title: Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1.
  3. In this review, we highlight the present knowledge of the identified disease-associated POMT1 gene mutations and genetic animal models related to the POMT1 gene.
    Title: Molecular genetics of the POMT1-related muscular dystrophy-dystroglycanopathies.
  4. The child was found to carry a heterozygous missense mutation c.1939G>A (p.Ala647Thr) in exon 19 of the protein-O-mannosyltransferase 1 (POMT1) gene inherited from the mother and a heterozygous frameshift mutation c.2141delG (p.Trp714Ter) in exon 20 inherited from the father.
    Title: [Analysis of POMT1 gene mutation in a pedigree affected with congenital muscular dystrophy].
  5. These findings may expand phenotype and mutation spectrum of the POMT1 gene. Clinical diagnosis supplemented with molecular screening may result in more accurate diagnoses of, prognoses for, and improved genetic counselling for this disease
    Title: Compound heterozygous POMT1 mutations in a Chinese family with autosomal recessive muscular dystrophy-dystroglycanopathy C1.
  6. O-mannosylation of cadherins and protocadherins does not require POMT1 and/or POMT2 in contrast to alpha-dystroglycan, and moreover, the O-Man glycans on cadherins are not elongated.
    Title: Mammalian O-mannosylation of cadherins and plexins is independent of protein O-mannosyltransferases 1 and 2.
  7. results demonstrate functional and biochemical similarities between POMT1 and its orthologue from bakers' yeast Pmt4.
    Title: Functional Similarities between the Protein O-Mannosyltransferases Pmt4 from Bakers' Yeast and Human POMT1.
  8. Our results suggest that POMT activity is inversely proportional to clinical severity, and demonstrate that skin fibroblasts can be used for differential diagnosis of patients with alpha-dystroglycanopathies. We have provided clinical, histological, enzymatic and genetic evidence of POMT1 involvement in five unrelated Chinese patients.
    Title: Analysis of phenotype, enzyme activity and genotype of Chinese patients with POMT1 mutation.
  9. Inhibition of POMT1/2 in human mesencyhmal stem cells , resulted in complete abolishment of chondrogenesis and alterations of adipogenic and osteogenic potential together with a lethal effect during myogenic induction.
    Title: Protein O-mannosylation is crucial for human mesencyhmal stem cells fate.
  10. report of 2 male siblings and an unrelated female with early onset muscular dystrophy and intellectual disability with minimal structural brain anomalies and no ocular abnormalities; a novel missense mutation (c.1958C>T; p.Pro653Leu) was identified
    Title: A novel missense mutation in POMT1 modulates the severe congenital muscular dystrophy phenotype associated with POMT1 nonsense mutations.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37239

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables dolichyl-phosphate-mannose-protein mannosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables mannosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein O-linked glycosylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked glycosylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein O-linked mannosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum TAS
Traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in sarcoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein O-mannosyl-transferase 1
Names
dolichyl-phosphate-mannose--protein mannosyltransferase 1
testis tissue sperm-binding protein Li 57p
NP_001070833.1
NP_001070834.1
NP_001129585.1
NP_001129586.1
NP_001340122.2
NP_001340123.1
NP_001340124.1
NP_001340125.1
NP_001340126.2
NP_001340127.2
NP_001340128.2
NP_001340129.1
NP_001361618.1
NP_001361619.1
NP_001361620.1
NP_001361621.1
NP_001361622.1
NP_001361624.1
NP_001397953.1
NP_009102.4
XP_011516442.1
XP_011516443.1
XP_011516444.1
XP_011516445.1
XP_011516447.1
XP_047278596.1
XP_047278597.1
XP_047278598.1
XP_054217734.1
XP_054217735.1
XP_054217736.1
XP_054217737.1
XP_054217738.1
XP_054217739.1
XP_054217740.1
XP_054217741.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008896.2 RefSeqGene

    Range
    5017..25898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_842

mRNA and Protein(s)

  1. NM_001077365.2 → NP_001070833.1  protein O-mannosyl-transferase 1 isoform b

    See identical proteins and their annotated locations for NP_001070833.1

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS43894.1
    UniProtKB/TrEMBL
    A0A140VKE0, A0A1V1FTP4
    Related
    ENSP00000385797.4, ENST00000402686.8
    Conserved Domains (4) summary
    smart00472
    Location:299 → 356
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    COG1928
    Location:14 → 720
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    pfam02366
    Location:20 → 267
    PMT; Dolichyl-phosphate-mannose-protein mannosyltransferase
    pfam16192
    Location:520 → 718
    PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase

  2. NM_001077366.2 → NP_001070834.1  protein O-mannosyl-transferase 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS43895.1
    UniProtKB/TrEMBL
    B4DEA0
    Related
    ENSP00000343034.7, ENST00000341012.13
    Conserved Domains (1) summary
    COG1928
    Location:6 → 666
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

  3. NM_001136113.2 → NP_001129585.1  protein O-mannosyl-transferase 1 isoform b

    See identical proteins and their annotated locations for NP_001129585.1

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS43894.1
    UniProtKB/TrEMBL
    A0A140VKE0, A0A1V1FTP4
    Related
    ENSP00000503281.1, ENST00000676640.1
    Conserved Domains (4) summary
    smart00472
    Location:299 → 356
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    COG1928
    Location:14 → 720
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    pfam02366
    Location:20 → 267
    PMT; Dolichyl-phosphate-mannose-protein mannosyltransferase
    pfam16192
    Location:520 → 718
    PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase

  4. NM_001136114.2 → NP_001129586.1  protein O-mannosyl-transferase 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS48045.1
    UniProtKB/TrEMBL
    B4DEA0
    Related
    ENSP00000503772.1, ENST00000677216.1
    Conserved Domains (1) summary
    COG1928
    Location:2 → 603
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

  5. NM_001353193.2 → NP_001340122.2  protein O-mannosyl-transferase 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS6943.1
    UniProtKB/Swiss-Prot
    B3KQG0, B4DIF0, Q5JT01, Q5JT06, Q5JT08, Q8NC91, Q8TCA9, Q9NX32, Q9NX82, Q9UNT2, Q9Y6A1
    UniProtKB/TrEMBL
    A0A1V1FTP4
    Conserved Domains (1) summary
    COG1928
    Location:14 → 742
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

  6. NM_001353194.2 → NP_001340123.1  protein O-mannosyl-transferase 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS43895.1
    UniProtKB/TrEMBL
    B4DEA0
    Conserved Domains (1) summary
    COG1928
    Location:6 → 666
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

  7. NM_001353195.2 → NP_001340124.1  protein O-mannosyl-transferase 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS48045.1
    UniProtKB/TrEMBL
    B4DEA0
    Conserved Domains (1) summary
    COG1928
    Location:2 → 603
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

  8. NM_001353196.2 → NP_001340125.1  protein O-mannosyl-transferase 1 isoform e

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS94516.1
    UniProtKB/TrEMBL
    A0A1V1FTP4, B4DTW4
    Related
    ENSP00000503696.1, ENST00000678303.1
    Conserved Domains (1) summary
    COG1928
    Location:14 → 690
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

  9. NM_001353197.2 → NP_001340126.2  protein O-mannosyl-transferase 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL358781
    UniProtKB/TrEMBL
    A0A1V1FTP4
    Conserved Domains (1) summary
    COG1928
    Location:6 → 688
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

  10. NM_001353198.2 → NP_001340127.2  protein O-mannosyl-transferase 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AL358781
    UniProtKB/TrEMBL
    A0A1V1FTP4
    Conserved Domains (1) summary
    COG1928
    Location:6 → 688
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

  11. NM_001353199.2 → NP_001340128.2  protein O-mannosyl-transferase 1 isoform g

    Status: REVIEWED

    Source sequence(s)
    AL358781
    UniProtKB/TrEMBL
    B4DEA0
    Conserved Domains (1) summary
    COG1928
    Location:2 → 625
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

  12. NM_001353200.2 → NP_001340129.1  protein O-mannosyl-transferase 1 isoform h

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS94518.1
    UniProtKB/TrEMBL
    A0A7I2V2K0, B4DSA5
    Related
    ENSP00000502936.1, ENST00000677029.1
    Conserved Domains (1) summary
    cl25703
    Location:2 → 568
    PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase

  13. NM_001374689.1 → NP_001361618.1  protein O-mannosyl-transferase 1 isoform l

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Conserved Domains (1) summary
    COG1928
    Location:6 → 716
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

  14. NM_001374690.1 → NP_001361619.1  protein O-mannosyl-transferase 1 isoform i

    Status: REVIEWED

    Source sequence(s)
    AL358781
    UniProtKB/TrEMBL
    A0A1V1FTP4
    Conserved Domains (1) summary
    COG1928
    Location:14 → 647
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

  15. NM_001374691.1 → NP_001361620.1  protein O-mannosyl-transferase 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS48045.1
    UniProtKB/TrEMBL
    B4DEA0
    Related
    ENSP00000503356.1, ENST00000679189.1
    Conserved Domains (1) summary
    COG1928
    Location:2 → 603
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

  16. NM_001374692.1 → NP_001361621.1  protein O-mannosyl-transferase 1 isoform d

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS48045.1
    UniProtKB/TrEMBL
    B4DEA0
    Conserved Domains (1) summary
    COG1928
    Location:2 → 603
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

  17. NM_001374693.1 → NP_001361622.1  protein O-mannosyl-transferase 1 isoform j

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS94517.1
    UniProtKB/TrEMBL
    A0A1V1FTP4, A0A7I2V445
    Related
    ENSP00000503552.1, ENST00000677626.1
    Conserved Domains (1) summary
    COG1928
    Location:6 → 603
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

  18. NM_001374695.1 → NP_001361624.1  protein O-mannosyl-transferase 1 isoform k

    Status: REVIEWED

    Source sequence(s)
    AL358781
    UniProtKB/TrEMBL
    B4DSA5
    Conserved Domains (1) summary
    COG1928
    Location:2 → 590
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

  19. NM_001411024.1 → NP_001397953.1  protein O-mannosyl-transferase 1 isoform m

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS94519.1
    UniProtKB/TrEMBL
    Q5JT02
    Related
    ENSP00000361294.5, ENST00000372220.5

  20. NM_007171.4 → NP_009102.4  protein O-mannosyl-transferase 1 isoform a

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Consensus CDS
    CCDS6943.1
    UniProtKB/Swiss-Prot
    B3KQG0, B4DIF0, Q5JT01, Q5JT06, Q5JT08, Q8NC91, Q8TCA9, Q9NX32, Q9NX82, Q9UNT2, Q9Y6A1
    UniProtKB/TrEMBL
    A0A1V1FTP4
    Related
    ENSP00000361302.3, ENST00000372228.9
    Conserved Domains (1) summary
    COG1928
    Location:14 → 742
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

RNA

  1. NR_148391.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358781

  2. NR_148392.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358781

  3. NR_148393.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358781

  4. NR_148394.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Related
    ENST00000678833.1

  5. NR_148395.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Related
    ENST00000679111.1

  6. NR_148396.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358781

  7. NR_148397.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Related
    ENST00000677099.1

  8. NR_148398.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Related
    ENST00000677853.1

  9. NR_148399.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358781

  10. NR_148400.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358781
    Related
    ENST00000678626.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    131502918..131523799
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518140.3 → XP_011516442.1  protein O-mannosyl-transferase 1 isoform X1

    UniProtKB/TrEMBL
    A0A1V1FTP4
    Conserved Domains (4) summary
    smart00472
    Location:272 → 329
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    COG1928
    Location:14 → 693
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    pfam02366
    Location:20 → 240
    PMT; Dolichyl-phosphate-mannose-protein mannosyltransferase
    pfam16192
    Location:493 → 691
    PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase

  2. XM_011518141.3 → XP_011516443.1  protein O-mannosyl-transferase 1 isoform X2

    UniProtKB/TrEMBL
    A0A1V1FTP4
    Conserved Domains (4) summary
    smart00472
    Location:250 → 307
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    COG1928
    Location:14 → 671
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    pfam02366
    Location:20 → 218
    PMT; Dolichyl-phosphate-mannose-protein mannosyltransferase
    pfam16192
    Location:471 → 669
    PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase

  3. XM_011518143.3 → XP_011516445.1  protein O-mannosyl-transferase 1 isoform X4

    Conserved Domains (2) summary
    smart00472
    Location:287 → 344
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    pfam16192
    Location:437 → 635
    PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase

  4. XM_011518142.3 → XP_011516444.1  protein O-mannosyl-transferase 1 isoform X3

    UniProtKB/TrEMBL
    B4DSA5
    Conserved Domains (4) summary
    smart00472
    Location:218 → 275
    MIR; Domain in ryanodine and inositol trisphosphate receptors and protein O-mannosyltransferases
    COG1928
    Location:6 → 639
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]
    pfam02366
    Location:1 → 186
    PMT; Dolichyl-phosphate-mannose-protein mannosyltransferase
    pfam16192
    Location:439 → 637
    PMT_4TMC; C-terminal four TMM region of protein-O-mannosyltransferase

  5. XM_047422640.1 → XP_047278596.1  protein O-mannosyl-transferase 1 isoform X5

  6. XM_011518145.3 → XP_011516447.1  protein O-mannosyl-transferase 1 isoform X7

    UniProtKB/TrEMBL
    B4DSA5
    Conserved Domains (1) summary
    COG1928
    Location:2 → 590
    PMT1; Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]

  7. XM_047422641.1 → XP_047278597.1  protein O-mannosyl-transferase 1 isoform X6

  8. XM_047422642.1 → XP_047278598.1  protein O-mannosyl-transferase 1 isoform X8

RNA

  1. XR_001746160.3 RNA Sequence

  2. XR_007061226.1 RNA Sequence

  3. XR_007061227.1 RNA Sequence

  4. XR_007061228.1 RNA Sequence

  5. XR_007061229.1 RNA Sequence

  6. XR_007061230.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    143715812..143736761
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361759.1 → XP_054217734.1  protein O-mannosyl-transferase 1 isoform X1

  2. XM_054361760.1 → XP_054217735.1  protein O-mannosyl-transferase 1 isoform X2

  3. XM_054361762.1 → XP_054217737.1  protein O-mannosyl-transferase 1 isoform X4

  4. XM_054361761.1 → XP_054217736.1  protein O-mannosyl-transferase 1 isoform X3

  5. XM_054361763.1 → XP_054217738.1  protein O-mannosyl-transferase 1 isoform X5

  6. XM_054361765.1 → XP_054217740.1  protein O-mannosyl-transferase 1 isoform X7

  7. XM_054361764.1 → XP_054217739.1  protein O-mannosyl-transferase 1 isoform X6

  8. XM_054361766.1 → XP_054217741.1  protein O-mannosyl-transferase 1 isoform X8

RNA

  1. XR_008487925.1 RNA Sequence

  2. XR_008487926.1 RNA Sequence

  3. XR_008487927.1 RNA Sequence

  4. XR_008487928.1 RNA Sequence

  5. XR_008487929.1 RNA Sequence

  6. XR_008487930.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6A1.3 GenPept UniProtKB/Swiss-Prot:Q9Y6A1

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