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GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase [ Cercocebus atys (sooty mangabey) ]

Gene ID: 105598144, updated on 13-Mar-2024

Summary

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Gene symbol
GNE
Gene description
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
See related
Ensembl:ENSCATG00000033005
Gene type
protein coding
RefSeq status
MODEL
Organism
Cercocebus atys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Cercocebus
Orthologs
human mouse all
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Genomic context

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See GNE in Genome Data Viewer
Location:
chromosome: Un
Exon count:
14
Annotation release Status Assembly Chr Location
100 current Caty_1.0 (GCF_000955945.1) Unplaced Scaffold NW_012002215.1 (1346745..1412612, complement)

NW_012002215.1Genomic Context describing neighboring genes Neighboring gene calicin Neighboring gene clathrin light chain A Neighboring gene high mobility group protein B3-like Neighboring gene ring finger protein 38

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012002215.1 Unplaced Scaffold Reference Caty_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables N-acylmannosamine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables UDP-N-acetylglucosamine 2-epimerase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in UDP-N-acetylglucosamine metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cercocebus atys Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Caty_1.0

Genomic

  1. NW_012002215.1 Reference Caty_1.0

    Range
    1346745..1412612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012087132.1 → XP_011942522.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X8

    See identical proteins and their annotated locations for XP_011942522.1

    UniProtKB/TrEMBL
    A0A2K5LZG1, A0A2K5LZQ7
    Related
    ENSCATP00000018340.1, ENSCATT00000042515.1
    Conserved Domains (2) summary
    COG1940
    Location:404 → 708
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    cl27436
    Location:42 → 369
    Epimerase_2; UDP-N-acetylglucosamine 2-epimerase

  2. XM_012087124.1 → XP_011942514.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X1

    See identical proteins and their annotated locations for XP_011942514.1

    UniProtKB/TrEMBL
    A0A2K5LZI6, A0A2K5LZQ7
    Related
    ENSCATP00000018360.1, ENSCATT00000042535.1
    Conserved Domains (4) summary
    cd03786
    Location:42 → 406
    GT1_UDP-GlcNAc_2-Epimerase; Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues ...
    COG1940
    Location:440 → 744
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    TIGR03568
    Location:42 → 405
    NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
    cl17037
    Location:441 → 700
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. XM_012087131.1 → XP_011942521.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X7

    See identical proteins and their annotated locations for XP_011942521.1

    UniProtKB/TrEMBL
    A0A2K5LZH5, A0A2K5LZQ7
    Related
    ENSCATP00000018344.1, ENSCATT00000042519.1
    Conserved Domains (2) summary
    COG1940
    Location:299 → 603
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    cl27436
    Location:2 → 264
    Epimerase_2; UDP-N-acetylglucosamine 2-epimerase

  4. XM_012087130.1 → XP_011942520.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X6

    See identical proteins and their annotated locations for XP_011942520.1

    UniProtKB/TrEMBL
    A0A2K5LZL2, A0A2K5LZQ7
    Related
    ENSCATP00000018387.1, ENSCATT00000042563.1
    Conserved Domains (4) summary
    cd03786
    Location:11 → 375
    GT1_UDP-GlcNAc_2-Epimerase; Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues ...
    COG1940
    Location:480 → 639
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    TIGR03568
    Location:11 → 374
    NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
    cl17037
    Location:481 → 595
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  5. XM_012087125.1 → XP_011942515.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X2

    See identical proteins and their annotated locations for XP_011942515.1

    UniProtKB/TrEMBL
    A0A2K5LZM3, A0A2K5LZQ7
    Related
    ENSCATP00000018386.1, ENSCATT00000042562.1
    Conserved Domains (2) summary
    COG1940
    Location:409 → 713
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    TIGR03568
    Location:11 → 374
    NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing

  6. XM_012087129.1 → XP_011942519.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X5

    UniProtKB/TrEMBL
    A0A2K5LZQ7
    Conserved Domains (2) summary
    COG1940
    Location:350 → 654
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    TIGR03568
    Location:2 → 315
    NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing

  7. XM_012087126.1 → XP_011942516.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X2

    See identical proteins and their annotated locations for XP_011942516.1

    UniProtKB/TrEMBL
    A0A2K5LZM3, A0A2K5LZQ7
    Related
    ENSCATP00000018415.1, ENSCATT00000042591.1
    Conserved Domains (2) summary
    COG1940
    Location:409 → 713
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    TIGR03568
    Location:11 → 374
    NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing

  8. XM_012087128.1 → XP_011942518.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X4

    UniProtKB/TrEMBL
    A0A2K5LZQ7
    Conserved Domains (4) summary
    cd03786
    Location:42 → 406
    GT1_UDP-GlcNAc_2-Epimerase; Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues ...
    COG1940
    Location:511 → 670
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    TIGR03568
    Location:42 → 405
    NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
    cl17037
    Location:512 → 626
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  9. XM_012087127.1 → XP_011942517.1  bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform X3

    UniProtKB/TrEMBL
    A0A2K5LZQ7
    Related
    ENSCATP00000018421.1, ENSCATT00000042598.1
    Conserved Domains (4) summary
    cd03786
    Location:42 → 355
    GT1_UDP-GlcNAc_2-Epimerase; Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues ...
    COG1940
    Location:389 → 693
    NagC; Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Transcription, Carbohydrate transport and metabolism]
    TIGR03568
    Location:42 → 354
    NeuC_NnaA; UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing
    cl17037
    Location:390 → 649
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein
Heading Accession and Version

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