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C1R complement C1r [ Cercocebus atys (sooty mangabey) ]

Gene ID: 105583055, updated on 13-Mar-2024

Summary

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Gene symbol
C1R
Gene description
complement C1r
See related
Ensembl:ENSCATG00000038989
Gene type
protein coding
RefSeq status
MODEL
Organism
Cercocebus atys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Cercocebus
Orthologs
human all
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Genomic context

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See C1R in Genome Data Viewer
Location:
chromosome: Un
Exon count:
13
Annotation release Status Assembly Chr Location
100 current Caty_1.0 (GCF_000955945.1) Unplaced Scaffold NW_012007478.1 (7332707..7348333, complement)

NW_012007478.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein with KRAB and SCAN domains 1-like Neighboring gene complement C1s Neighboring gene uncharacterized LOC105583056 Neighboring gene complement C1r subcomponent-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012007478.1 Unplaced Scaffold Reference Caty_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in complement activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in zymogen activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in blood microparticle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
complement C1r subcomponent

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cercocebus atys Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Caty_1.0

Genomic

  1. NW_012007478.1 Reference Caty_1.0

    Range
    7332707..7348333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012054400.1 → XP_011909790.1  complement C1r subcomponent isoform X2

    See identical proteins and their annotated locations for XP_011909790.1

    UniProtKB/TrEMBL
    A0A2K5N2T2
    Related
    ENSCATP00000031779.1, ENSCATT00000056045.1
    Conserved Domains (6) summary
    smart00020
    Location:463 → 697
    Tryp_SPc; Trypsin-like serine protease
    smart00042
    Location:27 → 138
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    cd00190
    Location:464 → 699
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00084
    Location:309 → 371
    Sushi; Sushi repeat (SCR repeat)
    pfam00431
    Location:193 → 302
    CUB; CUB domain
    pfam14670
    Location:161 → 189
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_012054398.1 → XP_011909788.1  complement C1r subcomponent isoform X2

    See identical proteins and their annotated locations for XP_011909788.1

    UniProtKB/TrEMBL
    A0A2K5N2T2
    Related
    ENSCATP00000031775.1, ENSCATT00000056041.1
    Conserved Domains (6) summary
    smart00020
    Location:463 → 697
    Tryp_SPc; Trypsin-like serine protease
    smart00042
    Location:27 → 138
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    cd00190
    Location:464 → 699
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00084
    Location:309 → 371
    Sushi; Sushi repeat (SCR repeat)
    pfam00431
    Location:193 → 302
    CUB; CUB domain
    pfam14670
    Location:161 → 189
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  3. XM_012054397.1 → XP_011909787.1  complement C1r subcomponent isoform X1

    UniProtKB/TrEMBL
    A0A2K5N2R4
    Related
    ENSCATP00000031783.1, ENSCATT00000056049.1
    Conserved Domains (6) summary
    smart00020
    Location:477 → 711
    Tryp_SPc; Trypsin-like serine protease
    smart00042
    Location:41 → 152
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    cd00190
    Location:478 → 713
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00084
    Location:323 → 385
    Sushi; Sushi repeat (SCR repeat)
    pfam00431
    Location:207 → 316
    CUB; CUB domain
    pfam14670
    Location:175 → 203
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
Heading Accession and Version

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