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PSEN2 presenilin 2 [ Cercocebus atys (sooty mangabey) ]

Gene ID: 105576920, updated on 13-Mar-2024

Summary

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Gene symbol
PSEN2
Gene description
presenilin 2
See related
Ensembl:ENSCATG00000043861
Gene type
protein coding
RefSeq status
MODEL
Organism
Cercocebus atys
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Cercocebus
Orthologs
human mouse all
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Genomic context

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See PSEN2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
14
Annotation release Status Assembly Chr Location
100 current Caty_1.0 (GCF_000955945.1) Unplaced Scaffold NW_012004936.1 (635774..661635, complement)

NW_012004936.1Genomic Context describing neighboring genes Neighboring gene CDC42 binding protein kinase alpha Neighboring gene uncharacterized LOC105576918 Neighboring gene coenzyme Q8A Neighboring gene uncharacterized LOC105576921 Neighboring gene inositol-trisphosphate 3-kinase B Neighboring gene stum, mechanosensory transduction mediator homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012004936.1 Unplaced Scaffold Reference Caty_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aspartic endopeptidase activity, intramembrane cleaving IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Notch receptor processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid precursor protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in amyloid-beta metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in calcium ion transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in membrane protein ectodomain proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in ciliary rootlet IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in dendritic shaft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in growth cone IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuromuscular junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
presenilin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Cercocebus atys Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Caty_1.0

Genomic

  1. NW_012004936.1 Reference Caty_1.0

    Range
    635774..661635 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012040503.1 → XP_011895893.1  presenilin-2 isoform X2

    See identical proteins and their annotated locations for XP_011895893.1

    UniProtKB/TrEMBL
    A0A2K5NYU1, A0A2K5NYW1
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 437
    Presenilin; Presenilin

  2. XM_012040500.1 → XP_011895890.1  presenilin-2 isoform X1

    See identical proteins and their annotated locations for XP_011895890.1

    UniProtKB/TrEMBL
    A0A2K5NYW1
    Related
    ENSCATP00000042551.1, ENSCATT00000066985.1
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 438
    Presenilin; Presenilin

  3. XM_012040501.1 → XP_011895891.1  presenilin-2 isoform X1

    See identical proteins and their annotated locations for XP_011895891.1

    UniProtKB/TrEMBL
    A0A2K5NYW1
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 438
    Presenilin; Presenilin

  4. XM_012040502.1 → XP_011895892.1  presenilin-2 isoform X2

    See identical proteins and their annotated locations for XP_011895892.1

    UniProtKB/TrEMBL
    A0A2K5NYU1, A0A2K5NYW1
    Related
    ENSCATP00000042531.1, ENSCATT00000066965.1
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 437
    Presenilin; Presenilin

  5. XM_012040498.1 → XP_011895888.1  presenilin-2 isoform X1

    See identical proteins and their annotated locations for XP_011895888.1

    UniProtKB/TrEMBL
    A0A2K5NYW1
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 438
    Presenilin; Presenilin

  6. XM_012040499.1 → XP_011895889.1  presenilin-2 isoform X1

    See identical proteins and their annotated locations for XP_011895889.1

    UniProtKB/TrEMBL
    A0A2K5NYW1
    Conserved Domains (1) summary
    pfam01080
    Location:82 → 438
    Presenilin; Presenilin
Nucleotide Protein
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