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PLCH1 phospholipase C eta 1 [ Mandrillus leucophaeus (drill) ]

Gene ID: 105552395, updated on 13-Mar-2024

Summary

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Gene symbol
PLCH1
Gene description
phospholipase C eta 1
See related
Ensembl:ENSMLEG00000038044
Gene type
protein coding
RefSeq status
MODEL
Organism
Mandrillus leucophaeus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Mandrillus
Orthologs
human mouse all
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Genomic context

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See PLCH1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
26
Annotation release Status Assembly Chr Location
100 current Mleu.le_1.0 (GCF_000951045.1) Unplaced Scaffold NW_012105964.1 (1190409..1445239)

NW_012105964.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 33 member 1 Neighboring gene chromosome unknown open reading frame, human C3orf33 Neighboring gene uncharacterized LOC105552394 Neighboring gene polyadenylate-binding protein 1-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012105964.1 Unplaced Scaffold Reference Mleu.le_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mandrillus leucophaeus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mleu.le_1.0

Genomic

  1. NW_012105964.1 Reference Mleu.le_1.0

    Range
    1190409..1445239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011998057.1 → XP_011853447.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X1

    UniProtKB/TrEMBL
    A0A2K5ZJ62
    Conserved Domains (8) summary
    cd00275
    Location:743 → 867
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:310 → 713
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:239 → 884
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:158 → 224
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:239 → 310
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:159 → 220
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:453 → 554
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:34 → 140
    PH-like; Pleckstrin homology-like domain

  2. XM_011998059.1 → XP_011853449.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X3

    UniProtKB/TrEMBL
    A0A2K5ZJ46, A0A2K5ZJA5
    Related
    ENSMLEP00000027847.1, ENSMLET00000051398.1
    Conserved Domains (8) summary
    cd00275
    Location:731 → 855
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:298 → 701
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:227 → 872
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:146 → 212
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:227 → 298
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:147 → 208
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:441 → 542
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:22 → 128
    PH-like; Pleckstrin homology-like domain

  3. XM_011998058.1 → XP_011853448.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 isoform X2

    UniProtKB/TrEMBL
    A0A2K5ZJ50, A0A2K5ZJ62
    Related
    ENSMLEP00000027846.1, ENSMLET00000051397.1
    Conserved Domains (8) summary
    cd00275
    Location:731 → 855
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08632
    Location:298 → 701
    PI-PLCc_eta1; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1
    PLN02228
    Location:227 → 872
    PLN02228; Phosphoinositide phospholipase C
    cd00051
    Location:146 → 212
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam09279
    Location:227 → 298
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    pfam13499
    Location:147 → 208
    EF-hand_7; EF-hand domain pair
    cl00292
    Location:441 → 542
    AANH_like; Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide.
    cl17171
    Location:22 → 128
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version

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