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DUSP4 dual specificity phosphatase 4 [ Mandrillus leucophaeus (drill) ]

Gene ID: 105538015, updated on 13-Mar-2024

Summary

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Gene symbol
DUSP4
Gene description
dual specificity phosphatase 4
See related
Ensembl:ENSMLEG00000044011
Gene type
protein coding
RefSeq status
MODEL
Organism
Mandrillus leucophaeus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Mandrillus
Orthologs
human mouse all
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Genomic context

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See DUSP4 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
5
Annotation release Status Assembly Chr Location
100 current Mleu.le_1.0 (GCF_000951045.1) Unplaced Scaffold NW_012101843.1 (4087831..4102448)

NW_012101843.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105538014 Neighboring gene 60S ribosomal protein L17 pseudogene Neighboring gene kinesin family member 13B Neighboring gene homeobox-containing protein 1-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012101843.1 Unplaced Scaffold Reference Mleu.le_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables MAP kinase tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in endoderm formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of MAPK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dual specificity protein phosphatase 4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mandrillus leucophaeus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mleu.le_1.0

Genomic

  1. NW_012101843.1 Reference Mleu.le_1.0

    Range
    4087831..4102448
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011977739.1 → XP_011833129.1  dual specificity protein phosphatase 4 isoform X1

    See identical proteins and their annotated locations for XP_011833129.1

    UniProtKB/TrEMBL
    A0A2K6AIU6
    Related
    ENSMLEP00000039989.1, ENSMLET00000063610.1
    Conserved Domains (2) summary
    cd01446
    Location:9 → 158
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cd14640
    Location:196 → 336
    DSP_DUSP4; dual specificity phosphatase domain of dual specificity protein phosphatase 4

  2. XM_011977741.1 → XP_011833131.1  dual specificity protein phosphatase 4 isoform X1

    See identical proteins and their annotated locations for XP_011833131.1

    UniProtKB/TrEMBL
    A0A2K6AIU6
    Conserved Domains (2) summary
    cd01446
    Location:9 → 158
    DSP_MapKP; N-terminal regulatory rhodanese domain of dual specificity phosphatases (DSP), such as Mapk Phosphatase. This domain is believed to determine substrate specificity by binding the substrate, such as ERK2, and activating the C-terminal catalytic domain by ...
    cd14640
    Location:196 → 336
    DSP_DUSP4; dual specificity phosphatase domain of dual specificity protein phosphatase 4

  3. XM_011977742.1 → XP_011833132.1  dual specificity protein phosphatase 4 isoform X2

    UniProtKB/TrEMBL
    A0A2K6AIT7
    Related
    ENSMLEP00000039992.1, ENSMLET00000063613.1
    Conserved Domains (1) summary
    cd00127
    Location:71 → 207
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...
Nucleotide Protein
Heading Accession and Version

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