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CBL Cbl proto-oncogene [ Mandrillus leucophaeus (drill) ]

Gene ID: 105528294, updated on 13-Mar-2024

Summary

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Gene symbol
CBL
Gene description
Cbl proto-oncogene
See related
Ensembl:ENSMLEG00000036210
Gene type
protein coding
RefSeq status
MODEL
Organism
Mandrillus leucophaeus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Mandrillus
Orthologs
human mouse all
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Genomic context

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See CBL in Genome Data Viewer
Location:
chromosome: Un
Exon count:
16
Annotation release Status Assembly Chr Location
100 current Mleu.le_1.0 (GCF_000951045.1) Unplaced Scaffold NW_012107697.1 (2180658..2276170)

NW_012107697.1Genomic Context describing neighboring genes Neighboring gene NHERF family PDZ scaffold protein 4 Neighboring gene dynein regulatory complex subunit 12 homolog Neighboring gene cell surface glycoprotein MUC18 Neighboring gene 39S ribosomal protein L40, mitochondrial pseudogene Neighboring gene ring finger protein 26

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012107697.1 Unplaced Scaffold Reference Mleu.le_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Mandrillus leucophaeus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mleu.le_1.0

Genomic

  1. NW_012107697.1 Reference Mleu.le_1.0

    Range
    2180658..2276170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011965007.1 → XP_011820397.1  E3 ubiquitin-protein ligase CBL

    UniProtKB/TrEMBL
    A0A2K5Z8Q3
    Related
    ENSMLEP00000024209.1, ENSMLET00000047730.1
    Conserved Domains (5) summary
    cd09920
    Location:206 → 302
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:331 → 373
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14393
    Location:807 → 846
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
    pfam02262
    Location:15 → 125
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:129 → 212
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
Nucleotide Protein
Heading Accession and Version

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