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C1R complement C1r [ Colobus angolensis palliatus ]

Gene ID: 105519176, updated on 13-Mar-2024

Summary

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Gene symbol
C1R
Gene description
complement C1r
See related
Ensembl:ENSCANG00000042855
Gene type
protein coding
RefSeq status
MODEL
Organism
Colobus angolensis palliatus (sub-species: palliatus)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Colobinae; Colobus
Orthologs
human all
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Genomic context

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See C1R in Genome Data Viewer
Location:
chromosome: Un
Exon count:
12
Annotation release Status Assembly Chr Location
100 current Cang.pa_1.0 (GCF_000951035.1) Unplaced Scaffold NW_012112030.1 (2581750..2592204, complement)

NW_012112030.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein with KRAB and SCAN domains 1-like Neighboring gene complement C1s Neighboring gene complement C1r subcomponent like Neighboring gene retinol binding protein 5

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012112030.1 Unplaced Scaffold Reference Cang.pa_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in complement activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in zymogen activation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in blood microparticle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
complement C1r subcomponent

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Colobus angolensis palliatus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Cang.pa_1.0

Genomic

  1. NW_012112030.1 Reference Cang.pa_1.0

    Range
    2581750..2592204 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011952477.1 → XP_011807867.1  complement C1r subcomponent isoform X2

    UniProtKB/TrEMBL
    A0A2K5KBB1, A0A2K5KBC0
    Related
    ENSCANP00000038379.1, ENSCANT00000061635.1
    Conserved Domains (6) summary
    smart00020
    Location:463 → 697
    Tryp_SPc; Trypsin-like serine protease
    smart00042
    Location:27 → 138
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    cd00190
    Location:464 → 699
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00084
    Location:309 → 371
    Sushi; Sushi repeat (SCR repeat)
    pfam00431
    Location:193 → 302
    CUB; CUB domain
    pfam14670
    Location:161 → 189
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_011952486.1 → XP_011807876.1  complement C1r subcomponent isoform X3

    UniProtKB/TrEMBL
    A0A2K5KBC0
    Conserved Domains (6) summary
    smart00020
    Location:429 → 663
    Tryp_SPc; Trypsin-like serine protease
    smart00042
    Location:27 → 104
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    cd00190
    Location:430 → 665
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00084
    Location:275 → 337
    Sushi; Sushi repeat (SCR repeat)
    pfam00431
    Location:159 → 268
    CUB; CUB domain
    pfam14670
    Location:127 → 155
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  3. XM_011952468.1 → XP_011807858.1  complement C1r subcomponent isoform X1

    UniProtKB/TrEMBL
    A0A2K5KBC0, A0A2K5KBC3
    Related
    ENSCANP00000038385.1, ENSCANT00000061641.1
    Conserved Domains (6) summary
    smart00020
    Location:478 → 712
    Tryp_SPc; Trypsin-like serine protease
    smart00042
    Location:42 → 153
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    cd00190
    Location:479 → 714
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00084
    Location:324 → 386
    Sushi; Sushi repeat (SCR repeat)
    pfam00431
    Location:208 → 317
    CUB; CUB domain
    pfam14670
    Location:176 → 204
    FXa_inhibition; Coagulation Factor Xa inhibitory site
Nucleotide Protein
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