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DYSF dysferlin [ Colobus angolensis palliatus ]

Gene ID: 105514064, updated on 13-Mar-2024

Summary

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Gene symbol
DYSF
Gene description
dysferlin
See related
Ensembl:ENSCANG00000027832
Gene type
protein coding
RefSeq status
MODEL
Organism
Colobus angolensis palliatus (sub-species: palliatus)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Colobinae; Colobus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
58
Annotation release Status Assembly Chr Location
100 current Cang.pa_1.0 (GCF_000951035.1) Unplaced Scaffold NW_012115599.1 (2115601..2349633, complement)

NW_012115599.1Genomic Context describing neighboring genes Neighboring gene exocyst complex component 6B Neighboring gene cytochrome P450 family 26 subfamily B member 1 Neighboring gene uncharacterized LOC105514065 Neighboring gene zinc finger protein 638 Neighboring gene poly(A) binding protein interacting protein 2B

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012115599.1 Unplaced Scaffold Reference Cang.pa_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent phospholipid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in T-tubule organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in macrophage activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in monocyte activation involved in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of phagocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in plasma membrane repair IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in vesicle fusion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in T-tubule IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dysferlin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Colobus angolensis palliatus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Cang.pa_1.0

Genomic

  1. NW_012115599.1 Reference Cang.pa_1.0

    Range
    2115601..2349633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011945196.1 → XP_011800586.1  dysferlin isoform X14

    UniProtKB/TrEMBL
    A0A2K5HZF6
    Conserved Domains (12) summary
    cd04011
    Location:217 → 326
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1138 → 1266
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:380 → 540
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1565 → 1688
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 133
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1799 → 1930
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:932 → 988
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:773 → 845
    FerB; FerB (NUC096) domain
    pfam08151
    Location:324 → 374
    FerI; FerI (NUC094) domain
    pfam08165
    Location:684 → 741
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1943 → 2029
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1334 → 1404
    C2; C2 domain

  2. XM_011945191.1 → XP_011800581.1  dysferlin isoform X10

    UniProtKB/TrEMBL
    A0A2K5HZF6
    Conserved Domains (12) summary
    cd04011
    Location:217 → 326
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1138 → 1266
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:380 → 540
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1586 → 1709
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 133
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1820 → 1951
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:932 → 988
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:773 → 845
    FerB; FerB (NUC096) domain
    pfam08151
    Location:324 → 374
    FerI; FerI (NUC094) domain
    pfam08165
    Location:684 → 741
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1964 → 2050
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1334 → 1404
    C2; C2 domain

  3. XM_011945193.1 → XP_011800583.1  dysferlin isoform X12

    UniProtKB/TrEMBL
    A0A2K5HZK6
    Conserved Domains (12) summary
    cd04011
    Location:217 → 326
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1152 → 1280
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:380 → 554
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1579 → 1702
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 133
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1813 → 1944
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:946 → 1002
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:787 → 859
    FerB; FerB (NUC096) domain
    pfam08151
    Location:324 → 374
    FerI; FerI (NUC094) domain
    pfam08165
    Location:698 → 755
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1957 → 2043
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1348 → 1418
    C2; C2 domain

  4. XM_011945187.1 → XP_011800577.1  dysferlin isoform X6

    UniProtKB/TrEMBL
    A0A2K5HZ83, A0A2K5HZF6
    Related
    ENSCANP00000009617.1, ENSCANT00000032493.1
    Conserved Domains (12) summary
    cd04011
    Location:217 → 326
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1152 → 1280
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:380 → 554
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1600 → 1723
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 133
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1834 → 1965
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:946 → 1002
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:787 → 859
    FerB; FerB (NUC096) domain
    pfam08151
    Location:324 → 374
    FerI; FerI (NUC094) domain
    pfam08165
    Location:698 → 755
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1978 → 2064
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1348 → 1418
    C2; C2 domain

  5. XM_011945189.1 → XP_011800579.1  dysferlin isoform X8

    UniProtKB/TrEMBL
    A0A2K5HZF6
    Conserved Domains (12) summary
    cd04011
    Location:248 → 357
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1169 → 1297
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:411 → 571
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1596 → 1719
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 133
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1830 → 1961
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:963 → 1019
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:804 → 876
    FerB; FerB (NUC096) domain
    pfam08151
    Location:355 → 405
    FerI; FerI (NUC094) domain
    pfam08165
    Location:715 → 772
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1974 → 2060
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1365 → 1435
    C2; C2 domain

  6. XM_011945182.1 → XP_011800572.1  dysferlin isoform X2

    UniProtKB/TrEMBL
    A0A2K5HYY1, A0A2K5HZF6
    Related
    ENSCANP00000009594.1, ENSCANT00000032470.1
    Conserved Domains (12) summary
    cd04011
    Location:248 → 357
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1169 → 1297
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:411 → 571
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1617 → 1740
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 133
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1851 → 1982
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:963 → 1019
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:804 → 876
    FerB; FerB (NUC096) domain
    pfam08151
    Location:355 → 405
    FerI; FerI (NUC094) domain
    pfam08165
    Location:715 → 772
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1995 → 2081
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1365 → 1435
    C2; C2 domain

  7. XM_011945185.1 → XP_011800575.1  dysferlin isoform X4

    UniProtKB/TrEMBL
    A0A2K5HZ09, A0A2K5HZK6
    Related
    ENSCANP00000009610.1, ENSCANT00000032487.1
    Conserved Domains (12) summary
    cd04011
    Location:248 → 357
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1183 → 1311
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:411 → 585
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1610 → 1733
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:20 → 133
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1844 → 1975
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:977 → 1033
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:818 → 890
    FerB; FerB (NUC096) domain
    pfam08151
    Location:355 → 405
    FerI; FerI (NUC094) domain
    pfam08165
    Location:729 → 786
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1988 → 2074
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1379 → 1449
    C2; C2 domain

  8. XM_011945195.1 → XP_011800585.1  dysferlin isoform X13

    UniProtKB/TrEMBL
    A0A2K5HZF6
    Conserved Domains (12) summary
    cd04011
    Location:218 → 327
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1139 → 1267
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:381 → 541
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1566 → 1689
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 134
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1800 → 1931
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:933 → 989
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:774 → 846
    FerB; FerB (NUC096) domain
    pfam08151
    Location:325 → 375
    FerI; FerI (NUC094) domain
    pfam08165
    Location:685 → 742
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1944 → 2030
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1335 → 1405
    C2; C2 domain

  9. XM_011945190.1 → XP_011800580.1  dysferlin isoform X9

    UniProtKB/TrEMBL
    A0A2K5HZF6
    Conserved Domains (12) summary
    cd04011
    Location:218 → 327
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1139 → 1267
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:381 → 541
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1587 → 1710
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 134
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1821 → 1952
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:933 → 989
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:774 → 846
    FerB; FerB (NUC096) domain
    pfam08151
    Location:325 → 375
    FerI; FerI (NUC094) domain
    pfam08165
    Location:685 → 742
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1965 → 2051
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1335 → 1405
    C2; C2 domain

  10. XM_011945192.1 → XP_011800582.1  dysferlin isoform X11

    UniProtKB/TrEMBL
    A0A2K5HZK6
    Conserved Domains (12) summary
    cd04011
    Location:218 → 327
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1153 → 1281
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:381 → 555
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1580 → 1703
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 134
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1814 → 1945
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:947 → 1003
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:788 → 860
    FerB; FerB (NUC096) domain
    pfam08151
    Location:325 → 375
    FerI; FerI (NUC094) domain
    pfam08165
    Location:699 → 756
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1958 → 2044
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1349 → 1419
    C2; C2 domain

  11. XM_011945186.1 → XP_011800576.1  dysferlin isoform X5

    UniProtKB/TrEMBL
    A0A2K5HZF6
    Conserved Domains (12) summary
    cd04011
    Location:218 → 327
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1153 → 1281
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:381 → 555
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1601 → 1724
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 134
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1835 → 1966
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:947 → 1003
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:788 → 860
    FerB; FerB (NUC096) domain
    pfam08151
    Location:325 → 375
    FerI; FerI (NUC094) domain
    pfam08165
    Location:699 → 756
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1979 → 2065
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1349 → 1419
    C2; C2 domain

  12. XM_011945188.1 → XP_011800578.1  dysferlin isoform X7

    UniProtKB/TrEMBL
    A0A2K5HZF6
    Conserved Domains (12) summary
    cd04011
    Location:249 → 358
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1170 → 1298
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:412 → 572
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1597 → 1720
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 134
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1831 → 1962
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:964 → 1020
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:805 → 877
    FerB; FerB (NUC096) domain
    pfam08151
    Location:356 → 406
    FerI; FerI (NUC094) domain
    pfam08165
    Location:716 → 773
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1975 → 2061
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1366 → 1436
    C2; C2 domain

  13. XM_011945181.1 → XP_011800571.1  dysferlin isoform X1

    UniProtKB/TrEMBL
    A0A2K5HZA3, A0A2K5HZF6
    Related
    ENSCANP00000009642.1, ENSCANT00000032517.1
    Conserved Domains (12) summary
    cd04011
    Location:249 → 358
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1170 → 1298
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:412 → 572
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1618 → 1741
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 134
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1852 → 1983
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:964 → 1020
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:805 → 877
    FerB; FerB (NUC096) domain
    pfam08151
    Location:356 → 406
    FerI; FerI (NUC094) domain
    pfam08165
    Location:716 → 773
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1996 → 2082
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1366 → 1436
    C2; C2 domain

  14. XM_011945184.1 → XP_011800574.1  dysferlin isoform X3

    UniProtKB/TrEMBL
    A0A2K5HZK6
    Conserved Domains (12) summary
    cd04011
    Location:249 → 358
    C2B_Ferlin; C2 domain second repeat in Ferlin
    cd04017
    Location:1184 → 1312
    C2D_Ferlin; C2 domain fourth repeat in Ferlin
    cd04018
    Location:412 → 586
    C2C_Ferlin; C2 domain third repeat in Ferlin
    cd04037
    Location:1611 → 1734
    C2E_Ferlin; C2 domain fifth repeat in Ferlin
    cd08373
    Location:5 → 134
    C2A_Ferlin; C2 domain first repeat in Ferlin
    cd08374
    Location:1845 → 1976
    C2F_Ferlin; C2 domain sixth repeat in Ferlin
    smart00693
    Location:978 → 1034
    DysFN; Dysferlin domain, N-terminal region
    pfam08150
    Location:819 → 891
    FerB; FerB (NUC096) domain
    pfam08151
    Location:356 → 406
    FerI; FerI (NUC094) domain
    pfam08165
    Location:730 → 787
    FerA; FerA (NUC095) domain
    pfam16165
    Location:1989 → 2075
    Ferlin_C; Ferlin C-terminus
    cl14603
    Location:1380 → 1450
    C2; C2 domain
Nucleotide Protein
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