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DGKA diacylglycerol kinase alpha [ Colobus angolensis palliatus ]

Gene ID: 105500569, updated on 18-Sep-2024

Summary

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Gene symbol
DGKA
Gene description
diacylglycerol kinase alpha
See related
Ensembl:ENSCANG00000029040
Gene type
protein coding
RefSeq status
MODEL
Organism
Colobus angolensis palliatus (sub-species: palliatus)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Colobinae; Colobus
Orthologs
human mouse all
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Genomic context

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See DGKA in Genome Data Viewer
Location:
chromosome: Un
Exon count:
27
Annotation release Status Assembly Chr Location
100 current Cang.pa_1.0 (GCF_000951035.1) Unplaced Scaffold NW_012120376.1 (7910665..7942097, complement)

NW_012120376.1Genomic Context describing neighboring genes Neighboring gene cyclin dependent kinase 2 Neighboring gene premelanosome protein Neighboring gene PYM homolog 1, exon junction complex associated factor Neighboring gene glutathione S-transferase P pseudogene Neighboring gene matrix metallopeptidase 19

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012120376.1 Unplaced Scaffold Reference Cang.pa_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP-dependent diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in diacylglycerol metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipid phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
diacylglycerol kinase alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Colobus angolensis palliatus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Cang.pa_1.0

Genomic

  1. NW_012120376.1 Reference Cang.pa_1.0

    Range
    7910665..7942097 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011926157.1 → XP_011781547.1  diacylglycerol kinase alpha isoform X1

    UniProtKB/TrEMBL
    A0A2K5I4C7
    Conserved Domains (7) summary
    smart00045
    Location:597 → 778
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:455 → 576
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:455 → 788
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00051
    Location:191 → 260
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:283 → 331
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:192 → 256
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:83 → 187
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  2. XM_011926158.1 → XP_011781548.1  diacylglycerol kinase alpha isoform X2

    See identical proteins and their annotated locations for XP_011781548.1

    UniProtKB/TrEMBL
    A0A2K5I4C7, A0A2K5I4D9
    Conserved Domains (7) summary
    smart00045
    Location:520 → 701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378 → 499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:378 → 711
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00051
    Location:114 → 183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:206 → 254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:115 → 179
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:6 → 110
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  3. XM_011926159.1 → XP_011781549.1  diacylglycerol kinase alpha isoform X2

    See identical proteins and their annotated locations for XP_011781549.1

    UniProtKB/TrEMBL
    A0A2K5I4C7, A0A2K5I4D9
    Related
    ENSCANP00000011387.1, ENSCANT00000034286.1
    Conserved Domains (7) summary
    smart00045
    Location:520 → 701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378 → 499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:378 → 711
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00051
    Location:114 → 183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:206 → 254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:115 → 179
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:6 → 110
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  4. XM_011926160.1 → XP_011781550.1  diacylglycerol kinase alpha isoform X2

    See identical proteins and their annotated locations for XP_011781550.1

    UniProtKB/TrEMBL
    A0A2K5I4C7, A0A2K5I4D9
    Conserved Domains (7) summary
    smart00045
    Location:520 → 701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378 → 499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:378 → 711
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00051
    Location:114 → 183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:206 → 254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:115 → 179
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:6 → 110
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  5. XM_011926161.1 → XP_011781551.1  diacylglycerol kinase alpha isoform X2

    See identical proteins and their annotated locations for XP_011781551.1

    UniProtKB/TrEMBL
    A0A2K5I4C7, A0A2K5I4D9
    Conserved Domains (7) summary
    smart00045
    Location:520 → 701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378 → 499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:378 → 711
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00051
    Location:114 → 183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:206 → 254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:115 → 179
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:6 → 110
    DAG_kinase_N; Diacylglycerol kinase N-terminus

  6. XM_011926162.1 → XP_011781552.1  diacylglycerol kinase alpha isoform X2

    See identical proteins and their annotated locations for XP_011781552.1

    UniProtKB/TrEMBL
    A0A2K5I4C7, A0A2K5I4D9
    Related
    ENSCANP00000011401.1, ENSCANT00000034300.1
    Conserved Domains (7) summary
    smart00045
    Location:520 → 701
    DAGKa; Diacylglycerol kinase accessory domain (presumed)
    smart00046
    Location:378 → 499
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG1597
    Location:378 → 711
    LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
    cd00051
    Location:114 → 183
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00130
    Location:206 → 254
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
    pfam13499
    Location:115 → 179
    EF-hand_7; EF-hand domain pair
    pfam14513
    Location:6 → 110
    DAG_kinase_N; Diacylglycerol kinase N-terminus
Nucleotide Protein
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