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AGRN agrin [ Macaca nemestrina (pig-tailed macaque) ]

Gene ID: 105498298, updated on 13-Mar-2024

Summary

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Gene symbol
AGRN
Gene description
agrin
See related
Ensembl:ENSMNEG00000039164
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca nemestrina
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See AGRN in Genome Data Viewer
Location:
chromosome: Un
Exon count:
41
Annotation release Status Assembly Chr Location
101 current Mnem_1.0 (GCF_000956065.1) Unplaced Scaffold NW_012012023.1 (276296..315593)

NW_012012023.1Genomic Context describing neighboring genes Neighboring gene hes family bHLH transcription factor 4 Neighboring gene ISG15 ubiquitin like modifier Neighboring gene uncharacterized LOC105498338 Neighboring gene ring finger protein 223

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012012023 Unplaced Scaffold Reference Mnem_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables laminin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in receptor clustering IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
agrin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca nemestrina Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mnem_1.0

Genomic

  1. NW_012012023.1 Reference Mnem_1.0

    Range
    276296..315593
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011770307.1 → XP_011768609.1  agrin isoform X1

    UniProtKB/TrEMBL
    A0A2K6D6U9
    Related
    ENSMNEP00000031667.1, ENSMNET00000056096.1
    Conserved Domains (9) summary
    smart00280
    Location:488 → 533
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1129 → 1253
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1824 → 1856
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:420 → 460
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00008
    Location:1332 → 1364
    EGF; EGF-like domain
    pfam00053
    Location:792 → 834
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1399 → 1530
    Laminin_G_1; Laminin G domain
    pfam03146
    Location:43 → 145
    NtA; Agrin NtA domain
    cl00097
    Location:348 → 388
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  2. XM_011770309.1 → XP_011768611.1  agrin isoform X3

    UniProtKB/TrEMBL
    A0A2K6D6U9
    Conserved Domains (9) summary
    smart00280
    Location:488 → 533
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1129 → 1253
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1824 → 1856
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:420 → 460
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00008
    Location:1332 → 1364
    EGF; EGF-like domain
    pfam00053
    Location:792 → 834
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1399 → 1530
    Laminin_G_1; Laminin G domain
    pfam03146
    Location:43 → 145
    NtA; Agrin NtA domain
    cl00097
    Location:348 → 388
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  3. XM_011770308.1 → XP_011768610.1  agrin isoform X2

    UniProtKB/TrEMBL
    A0A2K6D6U9
    Related
    ENSMNEP00000031648.1, ENSMNET00000056076.1
    Conserved Domains (9) summary
    smart00280
    Location:488 → 533
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1129 → 1253
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1820 → 1852
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:420 → 460
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00008
    Location:1332 → 1364
    EGF; EGF-like domain
    pfam00053
    Location:792 → 834
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1399 → 1530
    Laminin_G_1; Laminin G domain
    pfam03146
    Location:43 → 145
    NtA; Agrin NtA domain
    cl00097
    Location:348 → 388
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  4. XM_011770310.1 → XP_011768612.1  agrin isoform X4

    UniProtKB/TrEMBL
    A0A2K6D6U9
    Related
    ENSMNEP00000031670.1, ENSMNET00000056099.1
    Conserved Domains (8) summary
    smart00280
    Location:488 → 533
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1129 → 1253
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1820 → 1852
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:420 → 460
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00053
    Location:792 → 834
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1399 → 1530
    Laminin_G_1; Laminin G domain
    pfam03146
    Location:43 → 145
    NtA; Agrin NtA domain
    cl00097
    Location:348 → 388
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  5. XM_024798108.1 → XP_024653876.1  agrin isoform X5

    UniProtKB/TrEMBL
    A0A2K6D6U9
    Conserved Domains (9) summary
    smart00280
    Location:416 → 461
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1057 → 1181
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1752 → 1784
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:348 → 388
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00053
    Location:720 → 762
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1327 → 1458
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1260 → 1292
    EGF; EGF-like domain
    pfam03146
    Location:43 → 145
    NtA; Agrin NtA domain
    cl00097
    Location:276 → 316
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  6. XM_011770312.2 → XP_011768614.1  agrin isoform X7

    UniProtKB/TrEMBL
    A0A2K6D6W6
    Conserved Domains (7) summary
    smart00280
    Location:315 → 360
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:956 → 1080
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1651 → 1683
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:247 → 287
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00053
    Location:619 → 661
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1226 → 1357
    Laminin_G_1; Laminin G domain
    cl00097
    Location:175 → 215
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  7. XM_011770311.2 → XP_011768613.1  agrin isoform X6

    UniProtKB/TrEMBL
    A0A2K6D6W6
    Conserved Domains (7) summary
    smart00280
    Location:384 → 429
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:1025 → 1149
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1720 → 1752
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:316 → 356
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00053
    Location:688 → 730
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1295 → 1426
    Laminin_G_1; Laminin G domain
    cl00097
    Location:244 → 284
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  8. XM_024798109.1 → XP_024653877.1  agrin isoform X8

    UniProtKB/TrEMBL
    A0A2K6D6W6
    Conserved Domains (8) summary
    smart00280
    Location:312 → 357
    KAZAL; Kazal type serine protease inhibitors
    smart00200
    Location:953 → 1077
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    cd00054
    Location:1648 → 1680
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00104
    Location:244 → 284
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
    pfam00053
    Location:616 → 658
    Laminin_EGF; Laminin EGF domain
    pfam00054
    Location:1223 → 1354
    Laminin_G_1; Laminin G domain
    pfam00008
    Location:1156 → 1188
    EGF; EGF-like domain
    cl00097
    Location:172 → 212
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
Nucleotide Protein
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