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CAPN3 calpain 3 [ Macaca nemestrina (pig-tailed macaque) ]

Gene ID: 105491693, updated on 13-Mar-2024

Summary

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Gene symbol
CAPN3
Gene description
calpain 3
See related
Ensembl:ENSMNEG00000037223
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca nemestrina
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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See CAPN3 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
26
Annotation release Status Assembly Chr Location
101 current Mnem_1.0 (GCF_000956065.1) Unplaced Scaffold NW_012010577.1 (31849248..31916358, complement)

NW_012010577.1Genomic Context describing neighboring genes Neighboring gene synaptosome associated protein 23 Neighboring gene zinc finger protein 106 Neighboring gene U6 spliceosomal RNA Neighboring gene glucosidase alpha, neutral C Neighboring gene transmembrane protein 87A Neighboring gene VPS39 subunit of HOPS complex

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012010577 Unplaced Scaffold Reference Mnem_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca nemestrina Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mnem_1.0

Genomic

  1. NW_012010577.1 Reference Mnem_1.0

    Range
    31849248..31916358 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011758309.2 → XP_011756611.1  calpain-3 isoform X5

    See identical proteins and their annotated locations for XP_011756611.1

    Conserved Domains (3) summary
    pfam01067
    Location:1 → 67
    Calpain_III; Calpain large subunit, domain III
    pfam16648
    Location:71 → 141
    Calpain_u2; Unstructured region on Calpain-3
    cd16190
    Location:141 → 309
    EFh_PEF_CAPN3; Calcium-activated neutral

  2. XM_011758284.2 → XP_011756586.1  calpain-3 isoform X2

    See identical proteins and their annotated locations for XP_011756586.1

    UniProtKB/TrEMBL
    A0A2K6CWT1, A0A2K6CWU0
    Related
    ENSMNEP00000028137.1, ENSMNET00000052449.1
    Conserved Domains (4) summary
    pfam16648
    Location:583 → 653
    Calpain_u2; Unstructured region on Calpain-3
    cd16190
    Location:653 → 821
    EFh_PEF_CAPN3; Calcium-activated neutral
    pfam00648
    Location:75 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:436 → 579
    Calpain_III; Calpain large subunit, domain III

  3. XM_011758279.2 → XP_011756581.1  calpain-3 isoform X2

    See identical proteins and their annotated locations for XP_011756581.1

    UniProtKB/TrEMBL
    A0A2K6CWT1, A0A2K6CWU0
    Related
    ENSMNEP00000028122.1, ENSMNET00000052430.1
    Conserved Domains (4) summary
    pfam16648
    Location:583 → 653
    Calpain_u2; Unstructured region on Calpain-3
    cd16190
    Location:653 → 821
    EFh_PEF_CAPN3; Calcium-activated neutral
    pfam00648
    Location:75 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:436 → 579
    Calpain_III; Calpain large subunit, domain III

  4. XM_011758294.2 → XP_011756596.1  calpain-3 isoform X1

    See identical proteins and their annotated locations for XP_011756596.1

    UniProtKB/TrEMBL
    A0A2K6CWT0, A0A2K6CWU0
    Related
    ENSMNEP00000028124.1, ENSMNET00000052433.1
    Conserved Domains (4) summary
    cd16190
    Location:647 → 815
    EFh_PEF_CAPN3; Calcium-activated neutral
    pfam00648
    Location:75 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:436 → 574
    Calpain_III; Calpain large subunit, domain III
    pfam16648
    Location:583 → 647
    Calpain_u2; Unstructured region on Calpain-3

  5. XM_011758300.1 → XP_011756602.1  calpain-3 isoform X4

    Conserved Domains (4) summary
    cd16190
    Location:426 → 594
    EFh_PEF_CAPN3; Calcium-activated neutral
    pfam01067
    Location:209 → 347
    Calpain_III; Calpain large subunit, domain III
    pfam16648
    Location:356 → 426
    Calpain_u2; Unstructured region on Calpain-3
    cl00051
    Location:1 → 188
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.

  6. XM_024796353.1 → XP_024652121.1  calpain-3 isoform X3

    UniProtKB/TrEMBL
    A0A2K6CWU0
    Conserved Domains (5) summary
    pfam16648
    Location:583 → 653
    Calpain_u2; Unstructured region on Calpain-3
    cd15897
    Location:653 → 681
    EFh_PEF; EF-hand motif [structural motif]
    pfam00648
    Location:75 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:436 → 579
    Calpain_III; Calpain large subunit, domain III
    cl25352
    Location:653 → 705
    EFh_PEF; The penta-EF hand (PEF) family
Nucleotide Protein
Heading Accession and Version

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