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PC pyruvate carboxylase [ Macaca nemestrina (pig-tailed macaque) ]

Gene ID: 105469659, updated on 13-Mar-2024

Summary

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Gene symbol
PC
Gene description
pyruvate carboxylase
See related
Ensembl:ENSMNEG00000034122
Gene type
protein coding
RefSeq status
MODEL
Organism
Macaca nemestrina
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
27
Annotation release Status Assembly Chr Location
101 current Mnem_1.0 (GCF_000956065.1) Unplaced Scaffold NW_012013911.1 (5692956..5823092, complement)

NW_012013911.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105469808 Neighboring gene TOP6B like initiator of meiotic double strand breaks Neighboring gene Ras converting CAAX endopeptidase 1 Neighboring gene leucine rich repeat and fibronectin type III domain containing 4 Neighboring gene U7 small nuclear RNA Neighboring gene uncharacterized LOC105469660 Neighboring gene chromosome unknown C11orf86 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_012013911 Unplaced Scaffold Reference Mnem_1.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyruvate carboxylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in pyruvate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
pyruvate carboxylase, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Macaca nemestrina Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mnem_1.0

Genomic

  1. NW_012013911.1 Reference Mnem_1.0

    Range
    5692956..5823092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011720991.2 → XP_011719293.1  pyruvate carboxylase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A2K6CCJ7, A0A2K6CCL7
    Related
    ENSMNEP00000021395.1, ENSMNET00000045645.1
    Conserved Domains (7) summary
    cd06850
    Location:1112 → 1178
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:566 → 849
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:376 → 483
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    PRK12999
    Location:34 → 1179
    PRK12999; pyruvate carboxylase; Reviewed
    pfam00289
    Location:38 → 146
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:862 → 1061
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:152 → 359
    ATP-grasp_4; ATP-grasp domain

  2. XM_011720993.2 → XP_011719295.1  pyruvate carboxylase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011719295.1

    UniProtKB/TrEMBL
    A0A2K6CCL7
    Conserved Domains (7) summary
    cd06850
    Location:1111 → 1177
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:565 → 848
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:375 → 482
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    PRK12999
    Location:33 → 1178
    PRK12999; pyruvate carboxylase; Reviewed
    pfam00289
    Location:37 → 145
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:861 → 1060
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:151 → 358
    ATP-grasp_4; ATP-grasp domain

  3. XM_011720992.2 → XP_011719294.1  pyruvate carboxylase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011719294.1

    UniProtKB/TrEMBL
    A0A2K6CCL7
    Related
    ENSMNEP00000021388.1, ENSMNET00000045638.1
    Conserved Domains (7) summary
    cd06850
    Location:1111 → 1177
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:565 → 848
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:375 → 482
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    PRK12999
    Location:33 → 1178
    PRK12999; pyruvate carboxylase; Reviewed
    pfam00289
    Location:37 → 145
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:861 → 1060
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:151 → 358
    ATP-grasp_4; ATP-grasp domain

  4. XM_011720994.2 → XP_011719296.1  pyruvate carboxylase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011719296.1

    UniProtKB/TrEMBL
    A0A2K6CCL7
    Conserved Domains (7) summary
    cd06850
    Location:1111 → 1177
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:565 → 848
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:375 → 482
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    PRK12999
    Location:33 → 1178
    PRK12999; pyruvate carboxylase; Reviewed
    pfam00289
    Location:37 → 145
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:861 → 1060
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:151 → 358
    ATP-grasp_4; ATP-grasp domain

  5. XM_011720995.2 → XP_011719297.1  pyruvate carboxylase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011719297.1

    UniProtKB/TrEMBL
    A0A2K6CCL7
    Related
    ENSMNEP00000021404.1, ENSMNET00000045654.1
    Conserved Domains (7) summary
    cd06850
    Location:1111 → 1177
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:565 → 848
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:375 → 482
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    PRK12999
    Location:33 → 1178
    PRK12999; pyruvate carboxylase; Reviewed
    pfam00289
    Location:37 → 145
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:861 → 1060
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:151 → 358
    ATP-grasp_4; ATP-grasp domain

  6. XM_011720996.2 → XP_011719298.1  pyruvate carboxylase, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_011719298.1

    UniProtKB/TrEMBL
    A0A2K6CCL7
    Conserved Domains (7) summary
    cd06850
    Location:1111 → 1177
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:565 → 848
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:375 → 482
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    PRK12999
    Location:33 → 1178
    PRK12999; pyruvate carboxylase; Reviewed
    pfam00289
    Location:37 → 145
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:861 → 1060
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:151 → 358
    ATP-grasp_4; ATP-grasp domain
Nucleotide Protein
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