Gmpr2 guanosine monophosphate reductase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gmpr2provided by MGI
Official Full Name: guanosine monophosphate reductase 2provided by MGI
Primary source: MGI:MGI:1917903
See related: Ensembl:ENSMUSG00000002326 AllianceGenome:MGI:1917903
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GMPR 2; 1810008P16Rik; 5730544D12Rik
Summary: Predicted to enable GMP reductase activity. Predicted to be involved in GMP metabolic process. Predicted to act upstream of or within GMP catabolic process and monocyte differentiation. Predicted to be part of GMP reductase complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human GMPR2 (guanosine monophosphate reductase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in limb E14.5 (RPKM 13.5), thymus adult (RPKM 12.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 C3; 14 28.19 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (55909692..55935602)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (55672235..55687861)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GMP reductase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables GMP reductase activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within GMP catabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in GMP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in GMP metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in IMP salvage	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within monocyte differentiation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in purine nucleobase metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of GMP reductase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: GMP reductase 2

Names: guanosine 5'-monophosphate oxidoreductase 2

NP_818773.1

EC 1.7.1.7

XP_006518429.1

EC 1.7.1.7

XP_011243184.1

EC 1.7.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177992.2 → NP_818773.1 GMP reductase 2

See identical proteins and their annotated locations for NP_818773.1

Status: VALIDATED

Source sequence(s)

AK075772, BE956837, BY099107

Consensus CDS

CCDS27124.1

UniProtKB/Swiss-Prot

Q542X2, Q8R1T5, Q99L27

Related

ENSMUSP00000002397.6, ENSMUST00000002397.7

Conserved Domains (1) summary

PRK05096
Location:3 → 346

PRK05096; guanosine 5'-monophosphate oxidoreductase; Provisional

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

55909692..55935602

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011244882.4 → XP_011243184.1 GMP reductase 2 isoform X2

Conserved Domains (1) summary

PRK05096
Location:3 → 286

PRK05096; guanosine 5'-monophosphate oxidoreductase; Provisional
XM_006518366.3 → XP_006518429.1 GMP reductase 2 isoform X1

See identical proteins and their annotated locations for XP_006518429.1

UniProtKB/Swiss-Prot

Q542X2, Q8R1T5, Q99L27

Conserved Domains (1) summary

PRK05096
Location:3 → 346

PRK05096; guanosine 5'-monophosphate oxidoreductase; Provisional