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SIMALR suppressor of inflammatory macrophage apoptosis lncRNA [ Homo sapiens (human) ]

Gene ID: 105378020, updated on 26-Oct-2024

Summary

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Official Symbol
SIMALRprovided by HGNC
Official Full Name
suppressor of inflammatory macrophage apoptosis lncRNAprovided by HGNC
Primary source
HGNC:HGNC:53554
See related
AllianceGenome:HGNC:53554
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LINC02528
Expression
Low expression observed in reference dataset See more
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Genomic context

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See SIMALR in Genome Data Viewer
Location:
6q23.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (137943075..137945800, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (139131510..139134235, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (138264212..138266937, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17587 Neighboring gene long intergenic non-protein coding RNA 2539 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25145 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25146 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25147 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25149 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25150 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25151 Neighboring gene wound and keratinocyte migration associated lncRNA 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17589 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25154 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr6:138196296-138197495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:138200115-138200697 Neighboring gene TNF alpha induced protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25155 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25156 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:138246817-138248016 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25157 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17592 Neighboring gene NANOG hESC enhancer GRCh37_chr6:138276502-138277003 Neighboring gene long intergenic non-protein coding RNA 2865 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25158 Neighboring gene uncharacterized LOC105378021 Neighboring gene ribosomal protein SA pseudogene 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human Macrophage Long Intergenic Noncoding RNA, SIMALR, Suppresses Inflammatory Macrophage Apoptosis via NTN1 (Netrin-1). Cynn E, et al. Arterioscler Thromb Vasc Biol, 2023 Feb. PMID 36546321, Free PMC Article
  2. Ac4C modification of lncRNA SIMALR promotes nasopharyngeal carcinoma progression through activating eEF1A2 to facilitate ITGB4/ITGA6 translation. Gong S, et al. Oncogene, 2024 Sep. PMID 39154122

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ac4C modification of lncRNA SIMALR promotes nasopharyngeal carcinoma progression through activating eEF1A2 to facilitate ITGB4/ITGA6 translation.
    Title: Ac4C modification of lncRNA SIMALR promotes nasopharyngeal carcinoma progression through activating eEF1A2 to facilitate ITGB4/ITGA6 translation.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Genotypes

General gene information

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Other Names

  • long intergenic non-protein coding RNA 2528

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_149097.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591468

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    137943075..137945800 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    139131510..139134235 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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