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CPHXL cytoplasmic polyadenylated homeobox like [ Homo sapiens (human) ]

Gene ID: 105371346, updated on 13-Mar-2024

Summary

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Official Symbol
CPHXLprovided by HGNC
Official Full Name
cytoplasmic polyadenylated homeobox likeprovided by HGNC
Primary source
HGNC:HGNC:51815
See related
Ensembl:ENSG00000283755 MIM:618700; AllianceGenome:HGNC:51815
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPHXL1
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
16q23.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (75714131..75726490, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (81762420..81774779, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (75748029..75760388, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 520, pseudogene Neighboring gene double homeobox B Neighboring gene ATP synthase peripheral stalk-membrane subunit b pseudogene 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11147 Neighboring gene uncharacterized LOC105371348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11148 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:75854062-75855261 Neighboring gene uncharacterized LOC105371347 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr16:75870128-75870816 Neighboring gene RNA, 5S ribosomal pseudogene 430

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A family history of DUX4: phylogenetic analysis of DUXA, B, C and Duxbl reveals the ancestral DUX gene. Leidenroth A, et al. BMC Evol Biol, 2010 Nov 26. PMID 21110847, Free PMC Article
  2. Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development. Töhönen V, et al. Nat Commun, 2015 Sep 11. PMID 26360614, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cytoplasmic polyadenylated homeobox-like protein
Names
cytoplasmic polyadenylated homeobox 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355613.1 → NP_001342542.1  cytoplasmic polyadenylated homeobox-like protein

    Status: VALIDATED

    Source sequence(s)
    AC009122, AC025287, LN651082, LN651083
    Consensus CDS
    CCDS86543.1
    UniProtKB/Swiss-Prot
    A0A1W2PPM1
    Related
    ENSP00000491599.1, ENST00000640559.2
    Conserved Domains (1) summary
    smart00389
    Location:28 → 82
    HOX; Homeodomain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    75714131..75726490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    81762420..81774779 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A1W2PPM1.1 GenPept UniProtKB/Swiss-Prot:A0A1W2PPM1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials