Akr1c18 aldo-keto reductase family 1, member C18 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Akr1c18provided by MGI
Official Full Name: aldo-keto reductase family 1, member C18provided by MGI
Primary source: MGI:MGI:2145420
See related: Ensembl:ENSMUSG00000021214 AllianceGenome:MGI:2145420
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity. Acts upstream of or within parturition and progesterone catabolic process. Predicted to be located in cytoplasm and nucleus. Predicted to be active in cytosol. Is expressed in several structures, including adrenal gland; brain; female reproductive system; and lung. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; T-cell acute lymphoblastic leukemia; and leukemia. Orthologous to human AKR1C3 (aldo-keto reductase family 1 member C3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in adrenal adult (RPKM 70.0), ovary adult (RPKM 14.8) and 1 other tissue See more
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Genomic context

Location:: 13 A1; 13 2.31 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (4182614..4200645, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (4132615..4150646, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F2alpha (PGF2alpha) levels.
Title: Pregnane X receptor (PXR) deficiency promotes hepatocarcinogenesis via induction of Akr1c18 expression and prostaglandin F(2α) (PGF(2α)) levels.
the induction of luteal Akr1c18 by Galphaq/11 is mediated by the activation of phospholipase C.
Title: The Gα(q/11)-provoked induction of Akr1c18 in murine luteal cells is mediated by phospholipase C.
Data indicate that the expression of 20-alpha-hydroxysteroid dehydrogenase (20alpha-HSD; Akr1c18) was observed from gestation day (GD) 15.5 to post natal day (PN) 15.
Title: Ontogeny of adrenal-like glucocorticoid synthesis pathway and of 20α-hydroxysteroid dehydrogenase in the mouse lung.
results suggest that both maternal and fetal 20alpha-hydroxysteroid dehydrogenase (20alpha-HSD) play a role in maintaining normal pregnancy at least partially by reducing progesterone concentrations in fetuses
Title: Involvement of 20alpha-hydroxysteroid dehydrogenase in the maintenance of pregnancy in mice.
The role of 20alpha-HSD in functional luteolysis is relatively minor, but the number of pups, especially live pups, was markedly decreased in the 20alpha-HSD-/- mice.
Title: Reproductive phenotypes in mice with targeted disruption of the 20alpha-hydroxysteroid dehydrogenase gene.
observed an abnormally high expression levels of type 2 5alpha-reductase and 20alpha-HSD in the male and female adrenals, respectively, thus indirectly suggesting new roles for these sex-specific enzymes
Title: Quantitative appreciation of steroidogenic gene expression in mouse tissues: new roles for type 2 5alpha-reductase, 20alpha-hydroxysteroid dehydrogenase and estrogen sulfotransferase.
These results suggest that progesterone can be inactivated by 20alpha-hydroxysteroid dehydrogenase in some specific brain areas.
Title: Localization of 20alpha-hydroxysteroid dehydrogenase mRNA in mouse brain by in situ hybridization.
involvement of Sp1 and Sp3 in the expression of the 20alpha-HSD gene
Title: Characterization and functional analysis of the 5'-flanking region of the mouse 20alpha-hydroxysteroid dehydrogenase gene.
cloning and chromosome mapping of mouse 20alpha-hydroxysteroid dehydrogenase
Title: Cloning and chromosomal localization of mouse 20alpha-hydroxysteroid dehydrogenase gene.
prolactin activation of Stat5b is important in suppressing 20alpha-HSD gene expression and thereby allowing the maintenance of progesterone levels that are required to sustain pregnancy
Title: Regulation of progesterone levels during pregnancy and parturition by signal transducer and activator of transcription 5 and 20alpha-hydroxysteroid dehydrogenase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (2) 1 citation

General gene information

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Markers

Akr1c18 (e-PCR), detects polymorphism
- UniSTS:525621

AW146047 (e-PCR)
- UniSTS:165854

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	IDA Inferred from Direct Assay more info	PubMed
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables Delta4-3-oxosteroid 5beta-reductase activity	ISO Inferred from Sequence Orthology more info
enables aldo-keto reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables aldose reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables aldose reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info
enables aldose reductase (NADPH) activity	ISO Inferred from Sequence Orthology more info
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info
enables androsterone dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables androsterone dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables bile acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables geranylgeranyl reductase activity	ISO Inferred from Sequence Orthology more info
enables ketoreductase activity	ISO Inferred from Sequence Orthology more info
enables ketosteroid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ketosteroid monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor	ISO Inferred from Sequence Orthology more info
enables retinal dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables testosterone dehydrogenase [NAD(P)+] activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to corticosteroid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to follicle-stimulating hormone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to forskolin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to gonadotropin-releasing hormone	IEA Inferred from Electronic Annotation more info
involved_in cellular response to jasmonic acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prolactin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to prostaglandin D stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to prostaglandin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to testosterone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to transforming growth factor beta stimulus	ISO Inferred from Sequence Orthology more info
involved_in daunorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in daunorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in doxorubicin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in doxorubicin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in farnesol catabolic process	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of retinoic acid biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within parturition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within progesterone catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within progesterone catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in progesterone metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within progesterone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in progesterone metabolic process	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of steroid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of steroid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in retinal metabolic process	ISO Inferred from Sequence Orthology more info
involved_in testosterone biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: aldo-keto reductase family 1 member C18

Names: 20-alpha-HSD; 20-alpha-hydroxysteroid dehydrogenase; 20alpha-HSD; 20alpha-hydroxysteroid dehydrogenase

NP_001333464.1

EC 1.1.1.149

NP_598827.1

EC 1.1.1.149

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346535.1 → NP_001333464.1 aldo-keto reductase family 1 member C18 isoform 2

Status: VALIDATED

Source sequence(s)

AC122840, AV290179, BY224749, BY225131

Consensus CDS

CCDS84006.1

UniProtKB/Swiss-Prot

Q8K023

Related

ENSMUSP00000106332.3, ENSMUST00000110704.9
NM_134066.3 → NP_598827.1 aldo-keto reductase family 1 member C18 isoform 1

See identical proteins and their annotated locations for NP_598827.1

Status: VALIDATED

Source sequence(s)

AC122840

Consensus CDS

CCDS26219.1

UniProtKB/Swiss-Prot

Q8K023, Q99N44

UniProtKB/TrEMBL

Q3U538

Related

ENSMUSP00000021635.8, ENSMUST00000021635.9

Conserved Domains (2) summary

COG0656
Location:7 → 310

ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]

COG0667
Location:15 → 297

Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]