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BRCA1 BRCA1 DNA repair associated [ Pteropus vampyrus (large flying fox) ]

Gene ID: 105306256, updated on 30-Mar-2024

Summary

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Gene symbol
BRCA1
Gene description
BRCA1 DNA repair associated
Gene type
protein coding
RefSeq status
MODEL
Organism
Pteropus vampyrus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yinpterochiroptera; Pteropodoidea; Pteropodidae; Pteropodinae; Pteropus
Orthologs
human mouse all
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Genomic context

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See BRCA1 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
23
Annotation release Status Assembly Chr Location
101 current Pvam_2.0 (GCF_000151845.1) Unplaced Scaffold NW_011889213.1 (38691..84876)

NW_011889213.1Genomic Context describing neighboring genes Neighboring gene transmembrane protein 106A Neighboring gene NBR1 autophagy cargo receptor Neighboring gene Rho family GTPase 2 Neighboring gene vesicle amine transport 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_011889213 Unplaced Scaffold Reference Pvam_2.0

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in chordate embryonic development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in dosage compensation by inactivation of X chromosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of BRCA1-A complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of BRCA1-BARD1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
breast cancer type 1 susceptibility protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Pteropus vampyrus Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Pvam_2.0

Genomic

  1. NW_011889213.1 Reference Pvam_2.0

    Range
    38691..84876
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023523923.1 → XP_023379691.1  breast cancer type 1 susceptibility protein isoform X6

    UniProtKB/TrEMBL
    A0A6P6BX28
    Conserved Domains (6) summary
    smart00292
    Location:1709 → 1792
    BRCT; breast cancer carboxy-terminal domain
    pfam00533
    Location:1643 → 1701
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:345 → 502
    BRCT_assoc; Serine-rich domain associated with BRCT
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cl28246
    Location:1330 → 1488
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cl28410
    Location:15 → 149
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  2. XM_023523920.1 → XP_023379688.1  breast cancer type 1 susceptibility protein isoform X3

    UniProtKB/TrEMBL
    A0A6P6BX60
    Conserved Domains (6) summary
    smart00292
    Location:1735 → 1819
    BRCT; breast cancer carboxy-terminal domain
    pfam00533
    Location:1642 → 1700
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:345 → 502
    BRCT_assoc; Serine-rich domain associated with BRCT
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cl28246
    Location:1330 → 1487
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cl28410
    Location:15 → 149
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  3. XM_023523921.1 → XP_023379689.1  breast cancer type 1 susceptibility protein isoform X4

    UniProtKB/TrEMBL
    A0A6P6BX86
    Conserved Domains (6) summary
    smart00292
    Location:1734 → 1818
    BRCT; breast cancer carboxy-terminal domain
    pfam00533
    Location:1641 → 1699
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:344 → 501
    BRCT_assoc; Serine-rich domain associated with BRCT
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cl28246
    Location:1329 → 1486
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cl28410
    Location:15 → 121
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  4. XM_023523914.1 → XP_023379682.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    A0A6P6BXR2
    Conserved Domains (6) summary
    smart00292
    Location:1736 → 1820
    BRCT; breast cancer carboxy-terminal domain
    pfam00533
    Location:1643 → 1701
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:345 → 502
    BRCT_assoc; Serine-rich domain associated with BRCT
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cl28246
    Location:1330 → 1488
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cl28410
    Location:15 → 149
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  5. XM_011381155.2 → XP_011379457.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    A0A6P6BXR2
    Conserved Domains (6) summary
    smart00292
    Location:1736 → 1820
    BRCT; breast cancer carboxy-terminal domain
    pfam00533
    Location:1643 → 1701
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:345 → 502
    BRCT_assoc; Serine-rich domain associated with BRCT
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cl28246
    Location:1330 → 1488
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cl28410
    Location:15 → 149
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  6. XM_023523919.1 → XP_023379687.1  breast cancer type 1 susceptibility protein isoform X2

    UniProtKB/TrEMBL
    A0A6P6BX29
    Conserved Domains (6) summary
    smart00292
    Location:1735 → 1819
    BRCT; breast cancer carboxy-terminal domain
    pfam00533
    Location:1642 → 1700
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:344 → 501
    BRCT_assoc; Serine-rich domain associated with BRCT
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cl28246
    Location:1329 → 1487
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cl28410
    Location:15 → 121
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  7. XM_023523922.1 → XP_023379690.1  breast cancer type 1 susceptibility protein isoform X5

    UniProtKB/TrEMBL
    A0A6P6BXR7
    Conserved Domains (5) summary
    smart00292
    Location:1710 → 1794
    BRCT; breast cancer carboxy-terminal domain
    pfam00533
    Location:1617 → 1675
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:319 → 476
    BRCT_assoc; Serine-rich domain associated with BRCT
    cl17238
    Location:18 → 45
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl28246
    Location:1304 → 1462
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]

  8. XM_023523917.1 → XP_023379685.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    A0A6P6BXR2
    Conserved Domains (6) summary
    smart00292
    Location:1736 → 1820
    BRCT; breast cancer carboxy-terminal domain
    pfam00533
    Location:1643 → 1701
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:345 → 502
    BRCT_assoc; Serine-rich domain associated with BRCT
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cl28246
    Location:1330 → 1488
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cl28410
    Location:15 → 149
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  9. XM_023523916.1 → XP_023379684.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    A0A6P6BXR2
    Conserved Domains (6) summary
    smart00292
    Location:1736 → 1820
    BRCT; breast cancer carboxy-terminal domain
    pfam00533
    Location:1643 → 1701
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:345 → 502
    BRCT_assoc; Serine-rich domain associated with BRCT
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cl28246
    Location:1330 → 1488
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cl28410
    Location:15 → 149
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  10. XM_023523915.1 → XP_023379683.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    A0A6P6BXR2
    Conserved Domains (6) summary
    smart00292
    Location:1736 → 1820
    BRCT; breast cancer carboxy-terminal domain
    pfam00533
    Location:1643 → 1701
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:345 → 502
    BRCT_assoc; Serine-rich domain associated with BRCT
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cl28246
    Location:1330 → 1488
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cl28410
    Location:15 → 149
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  11. XM_023523918.1 → XP_023379686.1  breast cancer type 1 susceptibility protein isoform X1

    UniProtKB/TrEMBL
    A0A6P6BXR2
    Conserved Domains (6) summary
    smart00292
    Location:1736 → 1820
    BRCT; breast cancer carboxy-terminal domain
    pfam00533
    Location:1643 → 1701
    BRCT; BRCA1 C Terminus (BRCT) domain
    pfam12820
    Location:345 → 502
    BRCT_assoc; Serine-rich domain associated with BRCT
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cl28246
    Location:1330 → 1488
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    cl28410
    Location:15 → 149
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]

  12. XM_023523924.1 → XP_023379692.1  breast cancer type 1 susceptibility protein isoform X7

    UniProtKB/TrEMBL
    A0A6P6BX34
    Conserved Domains (4) summary
    smart00292
    Location:639 → 723
    BRCT; breast cancer carboxy-terminal domain
    pfam00533
    Location:546 → 604
    BRCT; BRCA1 C Terminus (BRCT) domain
    cd16498
    Location:18 → 65
    RING-HC_BRCA1; RING finger, HC subclass, found in breast cancer type 1 susceptibility protein (BRCA1) and similar proteins
    cl28410
    Location:15 → 149
    RAD18; RING-finger-containing E3 ubiquitin ligase [Signal transduction mechanisms]
Nucleotide Protein
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