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ZNF211 zinc finger protein 211 [ Homo sapiens (human) ]

Gene ID: 10520, updated on 7-Apr-2024

Summary

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Official Symbol
ZNF211provided by HGNC
Official Full Name
zinc finger protein 211provided by HGNC
Primary source
HGNC:HGNC:13003
See related
Ensembl:ENSG00000121417 MIM:601856; AllianceGenome:HGNC:13003
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF-25; C2H2-25; CH2H2-25
Summary
This gene encodes a protein containing a Kruppel-associated box domain and multiple zinc finger domains. This protein may play a role in developmental processes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in bone marrow (RPKM 5.3), thyroid (RPKM 4.5) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.43
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57633168..57644041)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60730097..60740970)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58144536..58155409)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15148 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15149 Neighboring gene zinc finger protein 530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15150 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11077 Neighboring gene zinc finger protein 134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15151 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11078 Neighboring gene MPRA-validated peak3574 silencer Neighboring gene zinc finger and SCAN domain containing 4 Neighboring gene tumor protein p63 regulated 1 like pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58193037-58193660 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11079 Neighboring gene zinc finger protein 551

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain. Becker KG, et al. Hum Mol Genet, 1995 Apr. PMID 7633419
  2. Molecular cloning and mapping of a novel developmentally regulated human C2H2-type zinc finger. Becker KG, et al. Mamm Genome, 1997 Apr. PMID 9096115
  3. OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer. Li J, et al. Theranostics, 2019. PMID 30662561, Free PMC Article
  4. Disrupted in Schizophrenia 1 Interactome: evidence for the close connectivity of risk genes and a potential synaptic basis for schizophrenia. Camargo LM, et al. Mol Psychiatry, 2007 Jan. PMID 17043677
  5. A High-Density Map for Navigating the Human Polycomb Complexome. Hauri S, et al. Cell Rep, 2016 Oct 4. PMID 27705803

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC131841

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 211
Names
zinc finger protein C2H2-25

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034028.1 RefSeqGene

    Range
    5002..15875
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001265597.3 → NP_001252526.1  zinc finger protein 211 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is longer than isoform 1.
    Source sequence(s)
    AC003682, AK294869, AL559417, BQ678885, DA961612, DR002950
    Consensus CDS
    CCDS58686.1
    UniProtKB/Swiss-Prot
    Q13398
    Related
    ENSP00000299871.5, ENST00000299871.9
    Conserved Domains (6) summary
    smart00349
    Location:46 → 106
    KRAB; krueppel associated box
    COG5048
    Location:244 → 615
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:520 → 540
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:518 → 540
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:46 → 85
    KRAB; KRAB box
    pfam13465
    Location:420 → 445
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001265598.3 → NP_001252527.1  zinc finger protein 211 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon and includes an alternate exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is longer than isoform 1.
    Source sequence(s)
    AC003682, AK294869, BQ678885, DA961612, DR002950
    Consensus CDS
    CCDS74468.1
    UniProtKB/TrEMBL
    A0A0A0MTK1
    Related
    ENSP00000442601.2, ENST00000541801.5
    Conserved Domains (6) summary
    smart00349
    Location:33 → 93
    KRAB; krueppel associated box
    COG5048
    Location:231 → 602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507 → 527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:505 → 527
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:33 → 72
    KRAB; KRAB box
    pfam13465
    Location:407 → 432
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001265599.3 → NP_001252528.1  zinc finger protein 211 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, initiates translation at a downstream, in-frame start codon and lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC003682, AK294869, AK296942, BQ678885, DA961612
    Consensus CDS
    CCDS58687.1
    UniProtKB/Swiss-Prot
    Q13398
    Related
    ENSP00000254182.7, ENST00000254182.11
    Conserved Domains (4) summary
    COG5048
    Location:170 → 541
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:446 → 466
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:444 → 466
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:346 → 371
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001265600.3 → NP_001252529.1  zinc finger protein 211 isoform 6

    See identical proteins and their annotated locations for NP_001252529.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (6) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC003682, AK294869, AK304666, BQ678885, DA961612
    Consensus CDS
    CCDS58688.1
    UniProtKB/Swiss-Prot
    Q13398
    Related
    ENSP00000375584.3, ENST00000391703.3
    Conserved Domains (4) summary
    COG5048
    Location:234 → 489
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:394 → 414
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:392 → 414
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:294 → 319
    zf-H2C2_2; Zinc-finger double domain

  5. NM_001322306.2 → NP_001309235.1  zinc finger protein 211 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC003682, BQ678885, DA961612
    Conserved Domains (4) summary
    COG5048
    Location:242 → 613
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:518 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:516 → 538
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:418 → 443
    zf-H2C2_2; Zinc-finger double domain

  6. NM_006385.5 → NP_006376.2  zinc finger protein 211 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AC003682, AK294869, BQ678885, DA745028, DA961612
    Consensus CDS
    CCDS12956.1
    UniProtKB/Swiss-Prot
    Q13398
    Related
    ENSP00000240731.4, ENST00000240731.5
    Conserved Domains (6) summary
    smart00349
    Location:46 → 87
    KRAB; krueppel associated box
    COG5048
    Location:192 → 563
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:468 → 488
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:466 → 488
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:46 → 85
    KRAB; KRAB box
    pfam13465
    Location:368 → 393
    zf-H2C2_2; Zinc-finger double domain

  7. NM_198855.4 → NP_942152.1  zinc finger protein 211 isoform 2

    See identical proteins and their annotated locations for NP_942152.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC003682, AK294869, AK304666, BC034351, BQ678885, DA961612
    Consensus CDS
    CCDS12957.1
    UniProtKB/Swiss-Prot
    B4DH10, B4DLC9, B4E3C9, B9ZVS7, B9ZVW1, F8WDV2, Q05BQ7, Q13398, Q2TAL7, Q59EG4, Q59G36, Q5EBL6
    Related
    ENSP00000339562.3, ENST00000347302.7
    Conserved Domains (6) summary
    smart00349
    Location:33 → 74
    KRAB; krueppel associated box
    COG5048
    Location:179 → 550
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:455 → 475
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:453 → 475
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:33 → 72
    KRAB; KRAB box
    pfam13465
    Location:355 → 380
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_049752.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) includes two alternate internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC003682, AK294869, BC018138, BQ678885, DA961612

  2. NR_049753.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC003682, AK294869, BC110856, BQ678885, DA961612

  3. NR_049754.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC003682, AK294869, AK297047, BQ678885, DA961612

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57633168..57644041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60730097..60740970
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001290231.1: Suppressed sequence

    Description
    NM_001290231.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q13398.2 GenPept UniProtKB/Swiss-Prot:Q13398

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