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Pelo pelota mRNA surveillance and ribosome rescue factor [ Mus musculus (house mouse) ]

Gene ID: 105083, updated on 28-Oct-2024

Summary

Official Symbol
Peloprovided by MGI
Official Full Name
pelota mRNA surveillance and ribosome rescue factorprovided by MGI
Primary source
MGI:MGI:2145154
See related
Ensembl:ENSMUSG00000042275 AllianceGenome:MGI:2145154
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable ribosome binding activity and stalled ribosome sensor activity. Acts upstream of or within several processes, including inner cell mass cell proliferation; mesenchymal to epithelial transition; and positive regulation of BMP signaling pathway. Predicted to be part of Dom34-Hbs1 complex. Predicted to be active in cytosolic ribosome. Is expressed in several structures, including central nervous system; genitourinary system; limb muscle; orbito-sphenoid; and spleen. Orthologous to human PELO (pelota mRNA surveillance and ribosome rescue factor). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in lung adult (RPKM 16.1), bladder adult (RPKM 15.2) and 28 other tissues See more
Orthologs
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Genomic context

See Pelo in Genome Data Viewer
Location:
13 D2.2; 13 64.61 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (115224891..115226694, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (115088355..115090158, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34790 Neighboring gene STARR-positive B cell enhancer ABC_E5421 Neighboring gene STARR-positive B cell enhancer mm9_chr13:115621672-115621973 Neighboring gene STARR-seq mESC enhancer starr_35768 Neighboring gene molybdenum cofactor synthesis 2 Neighboring gene integrin alpha 2 Neighboring gene predicted gene, 34845 Neighboring gene integrin alpha 1 Neighboring gene STARR-seq mESC enhancer starr_35769 Neighboring gene predicted gene 10734 Neighboring gene predicted gene, 41075 Neighboring gene predicted gene, 25985 Neighboring gene microfibrillar-associated protein 1B pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
 
enables ribosome binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables stalled ribosome sensor activity IEA
Inferred from Electronic Annotation
more info
 
enables stalled ribosome sensor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in RNA surveillance IEA
Inferred from Electronic Annotation
more info
 
involved_in cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within chromosome organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within endoderm development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within endoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner cell mass cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesenchymal to epithelial transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nonfunctional rRNA decay IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear-transcribed mRNA catabolic process, no-go decay IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nuclear-transcribed mRNA catabolic process, no-go decay ISO
Inferred from Sequence Orthology
more info
 
involved_in nuclear-transcribed mRNA catabolic process, no-go decay ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nuclear-transcribed mRNA catabolic process, non-stop decay IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
 
involved_in rescue of stalled ribosome ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in ribosome disassembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ribosome disassembly ISO
Inferred from Sequence Orthology
more info
 
involved_in ribosome disassembly ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of Dom34-Hbs1 complex ISO
Inferred from Sequence Orthology
more info
 
part_of Dom34-Hbs1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in cytosolic ribosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein pelota homolog
Names
pelota homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_134058.3NP_598819.2  protein pelota homolog

    See identical proteins and their annotated locations for NP_598819.2

    Status: VALIDATED

    Source sequence(s)
    AC175538, AI854576, BB767039, BC050209
    Consensus CDS
    CCDS26788.1
    UniProtKB/Swiss-Prot
    Q3TCN0, Q6PG91, Q80X73, Q91UZ2
    UniProtKB/TrEMBL
    Q3THL5
    Related
    ENSMUSP00000104849.4, ENSMUST00000109226.5
    Conserved Domains (4) summary
    COG1537
    Location:1371
    PelA; Stalled ribosome rescue protein Dom34, pelota family [Translation, ribosomal structure and biogenesis]
    pfam03463
    Location:1128
    eRF1_1; eRF1 domain 1
    pfam03464
    Location:136268
    eRF1_2; eRF1 domain 2
    pfam03465
    Location:271370
    eRF1_3; eRF1 domain 3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    115224891..115226694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)