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LOC105029281 probable E3 ubiquitin-protein ligase HERC1 [ Esox lucius (northern pike) ]

Gene ID: 105029281, updated on 18-Jun-2024

Summary

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Gene symbol
LOC105029281
Gene description
probable E3 ubiquitin-protein ligase HERC1
See related
Ensembl:ENSELUG00000031169
Gene type
protein coding
RefSeq status
MODEL
Organism
Esox lucius
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes; Esocidae; Esox
Orthologs
zebrafish all
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Genomic context

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See LOC105029281 in Genome Data Viewer
Location:
chromosome: 14
Exon count:
82
Annotation release Status Assembly Chr Location
104 current fEsoLuc1.pri (GCF_011004845.1) 14 NC_047582.1 (2225213..2411248)
103 previous assembly Eluc_v4 (GCF_004634155.1) Linkage Group LG14 NC_025981.4 (34982803..35161926, complement)

Chromosome 14 - NC_047582.1Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 24 Neighboring gene endothelial cell-specific molecule 1 Neighboring gene uncharacterized LOC114840879 Neighboring gene potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genome and linkage map of the northern pike (Esox lucius): conserved synteny revealed between the salmonid sister group and the Neoteleostei. Rondeau EB, et al. PLoS One, 2014. PMID 25069045, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase HERC1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Esox lucius Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fEsoLuc1.pri Primary Assembly

Genomic

  1. NC_047582.1 Reference fEsoLuc1.pri Primary Assembly

    Range
    2225213..2411248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_020044405.2 → XP_019899964.2  probable E3 ubiquitin-protein ligase HERC1 isoform X1

    UniProtKB/TrEMBL
    A0A6Q2ZN02
    Conserved Domains (7) summary
    COG5184
    Location:386 → 739
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4495 → 4863
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2769 → 2812
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3450 → 3489
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2012 → 2168
    SPRY_HERC1; SPRY domain in HERC1
    pfam00415
    Location:4021 → 4065
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    cl29593
    Location:3443 → 3798
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_034297070.1 → XP_034152961.1  probable E3 ubiquitin-protein ligase HERC1 isoform X4

    UniProtKB/TrEMBL
    A0A6Q2ZN02
    Conserved Domains (7) summary
    COG5184
    Location:386 → 739
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4467 → 4835
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    sd00039
    Location:3422 → 3461
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2012 → 2168
    SPRY_HERC1; SPRY domain in HERC1
    pfam00415
    Location:3993 → 4037
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    cl21463
    Location:2763 → 2784
    UBA_like_SF; UBA domain-like superfamily
    cl29593
    Location:3415 → 3770
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_020044408.2 → XP_019899967.2  probable E3 ubiquitin-protein ligase HERC1 isoform X3

    UniProtKB/TrEMBL
    A0A6Q2ZN02
    Conserved Domains (7) summary
    COG5184
    Location:386 → 739
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4487 → 4855
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2761 → 2804
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3442 → 3481
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2012 → 2168
    SPRY_HERC1; SPRY domain in HERC1
    pfam00415
    Location:4013 → 4057
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    cl29593
    Location:3435 → 3790
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_020044407.2 → XP_019899966.2  probable E3 ubiquitin-protein ligase HERC1 isoform X2

    UniProtKB/TrEMBL
    A0A6Q2ZN02
    Related
    ENSELUP00000089420.1, ENSELUT00000110953.1
    Conserved Domains (7) summary
    COG5184
    Location:386 → 739
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4494 → 4862
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2768 → 2811
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3449 → 3488
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2011 → 2167
    SPRY_HERC1; SPRY domain in HERC1
    pfam00415
    Location:4020 → 4064
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    cl29593
    Location:3442 → 3797
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_020044406.2 → XP_019899965.2  probable E3 ubiquitin-protein ligase HERC1 isoform X1

    UniProtKB/TrEMBL
    A0A6Q2ZN02
    Conserved Domains (7) summary
    COG5184
    Location:386 → 739
    ATS1; Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
    cd00078
    Location:4495 → 4863
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd14401
    Location:2769 → 2812
    UBA_HERC1; UBA domain found in probable E3 ubiquitin-protein ligase HERC1 and similar proteins
    sd00039
    Location:3450 → 3489
    7WD40; WD40 repeat [structural motif]
    cd12881
    Location:2012 → 2168
    SPRY_HERC1; SPRY domain in HERC1
    pfam00415
    Location:4021 → 4065
    RCC1; Regulator of chromosome condensation (RCC1) repeat
    cl29593
    Location:3443 → 3798
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein
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