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hic1 hypermethylated in cancer 1 [ Esox lucius (northern pike) ]

Gene ID: 105023188, updated on 18-Jun-2024

Summary

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Gene symbol
hic1
Gene description
hypermethylated in cancer 1
See related
Ensembl:ENSELUG00000045007
Gene type
protein coding
RefSeq status
MODEL
Organism
Esox lucius
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Esociformes; Esocidae; Esox
Orthologs
human zebrafish all
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Genomic context

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See hic1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
4
Annotation release Status Assembly Chr Location
104 current fEsoLuc1.pri (GCF_011004845.1) 1 NC_047569.1 (21999235..22016948)
103 previous assembly Eluc_v4 (GCF_004634155.1) Linkage Group LG01 NC_025968.4 (21158677..21176363, complement)

Chromosome 1 - NC_047569.1Genomic Context describing neighboring genes Neighboring gene TAO kinase 1a Neighboring gene TSR1 ribosome maturation factor Neighboring gene uncharacterized LOC117594398 Neighboring gene diphthamide biosynthesis 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genome and linkage map of the northern pike (Esox lucius): conserved synteny revealed between the salmonid sister group and the Neoteleostei. Rondeau EB, et al. PLoS One, 2014. PMID 25069045, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hypermethylated in cancer 1 protein
Names
HIC ZBTB transcriptional repressor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Esox lucius Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference fEsoLuc1.pri Primary Assembly

Genomic

  1. NC_047569.1 Reference fEsoLuc1.pri Primary Assembly

    Range
    21999235..22016948
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_029119596.2 → XP_028975429.1  hypermethylated in cancer 1 protein isoform X2

    Conserved Domains (4) summary
    sd00017
    Location:586 → 606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584 → 606
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:626 → 651
    zf-H2C2_2; Zinc-finger double domain
    cd18333
    Location:32 → 154
    BTB_POZ_ZBTB29_HIC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1)

  2. XM_010892181.5 → XP_010890483.1  hypermethylated in cancer 1 protein isoform X4

    See identical proteins and their annotated locations for XP_010890483.1

    Related
    ENSELUP00000087112.1, ENSELUT00000111461.1
    Conserved Domains (4) summary
    sd00017
    Location:561 → 581
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:559 → 581
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:601 → 626
    zf-H2C2_2; Zinc-finger double domain
    cd18333
    Location:7 → 129
    BTB_POZ_ZBTB29_HIC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1)

  3. XM_010892183.5 → XP_010890485.1  hypermethylated in cancer 1 protein isoform X4

    See identical proteins and their annotated locations for XP_010890485.1

    Conserved Domains (4) summary
    sd00017
    Location:561 → 581
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:559 → 581
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:601 → 626
    zf-H2C2_2; Zinc-finger double domain
    cd18333
    Location:7 → 129
    BTB_POZ_ZBTB29_HIC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1)

  4. XM_029119595.2 → XP_028975428.1  hypermethylated in cancer 1 protein isoform X1

    Conserved Domains (4) summary
    sd00017
    Location:605 → 625
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:603 → 625
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:645 → 670
    zf-H2C2_2; Zinc-finger double domain
    cd18333
    Location:51 → 173
    BTB_POZ_ZBTB29_HIC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1)

  5. XM_029119598.2 → XP_028975431.1  hypermethylated in cancer 1 protein isoform X4

    Related
    ENSELUP00000094586.1, ENSELUT00000091422.1
    Conserved Domains (4) summary
    sd00017
    Location:561 → 581
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:559 → 581
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:601 → 626
    zf-H2C2_2; Zinc-finger double domain
    cd18333
    Location:7 → 129
    BTB_POZ_ZBTB29_HIC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1)

  6. XM_010892182.5 → XP_010890484.1  hypermethylated in cancer 1 protein isoform X4

    See identical proteins and their annotated locations for XP_010890484.1

    Related
    ENSELUP00000093832.1, ENSELUT00000108578.1
    Conserved Domains (4) summary
    sd00017
    Location:561 → 581
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:559 → 581
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:601 → 626
    zf-H2C2_2; Zinc-finger double domain
    cd18333
    Location:7 → 129
    BTB_POZ_ZBTB29_HIC1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1)

  7. XM_010892178.5 → XP_010890480.1  hypermethylated in cancer 1 protein isoform X3

    UniProtKB/TrEMBL
    A0A3P8Z0N1
    Conserved Domains (6) summary
    smart00225
    Location:52 → 149
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:608 → 656
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:584 → 604
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:582 → 604
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:41 → 147
    BTB; BTB/POZ domain
    pfam13465
    Location:625 → 649
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein
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