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Dnal1 dynein, axonemal, light chain 1 [ Mus musculus (house mouse) ]

Gene ID: 105000, updated on 2-Nov-2024

Summary

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Official Symbol
Dnal1provided by MGI
Official Full Name
dynein, axonemal, light chain 1provided by MGI
Primary source
MGI:MGI:1921462
See related
Ensembl:ENSMUSG00000042523 AllianceGenome:MGI:1921462
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dnalc1; 1700010H15Rik; E330027P08Rik
Summary
Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be located in microtubule. Predicted to be part of outer dynein arm. Predicted to be active in cytoplasm. Is expressed in brain ependyma; node; and upper respiratory tract epithelium. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 16. Orthologous to human DNAL1 (dynein axonemal light chain 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in frontal lobe adult (RPKM 11.8), cortex adult (RPKM 9.6) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Dnal1 in Genome Data Viewer
Location:
12 D1; 12 39.05 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (84161057..84190291)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (84114279..84143517)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_32724 Neighboring gene acyl-CoA thioesterase 5 pseudogene Neighboring gene acyl-CoA thioesterase 6 Neighboring gene paraneoplastic antigen MA1 Neighboring gene mitotic deacetylase associated SANT domain protein Neighboring gene predicted gene, 40476

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients. Horváth J, et al. Am J Respir Cell Mol Biol, 2005 Jul. PMID 15845866
  2. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. Sang L, et al. Cell, 2011 May 13. PMID 21565611, Free PMC Article
  3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of the human (DNAL1) and murine (Dnal1) orthologs of the Chlamydomonas LC1-gene
    Title: Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC159095, MGC159097

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alpha-tubulin binding IEA
Inferred from Electronic Annotation
more info
  
enables alpha-tubulin binding ISO
Inferred from Sequence Orthology
more info
  
enables dynein heavy chain binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dynein heavy chain binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein heavy chain binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in outer dynein arm assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in outer dynein arm assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
part_of outer dynein arm ISA
Inferred from Sequence Alignment
more info
 PubMed 

General protein information

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Preferred Names
dynein axonemal light chain 1
Names
dynein light chain 1, axonemal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001346528.1 → NP_001333457.1  dynein axonemal light chain 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125071, AK005826, CF540410
    Consensus CDS
    CCDS83987.1
    UniProtKB/Swiss-Prot
    Q05A62
    Related
    ENSMUSP00000037076.3, ENSMUST00000046340.9

  2. NM_028821.3 → NP_083097.2  dynein axonemal light chain 1 isoform 1

    See identical proteins and their annotated locations for NP_083097.2

    Status: VALIDATED

    Source sequence(s)
    AC125071, BC070454, BY126068
    Consensus CDS
    CCDS26039.2
    UniProtKB/Swiss-Prot
    A0JLX1, Q05A62, Q9DAH9
    Related
    ENSMUSP00000121038.2, ENSMUST00000123491.8
    Conserved Domains (4) summary
    sd00031
    Location:50 → 71
    LRR_1; leucine-rich repeat [structural motif]
    sd00035
    Location:95 → 116
    LRR_NTF; leucine-rich repeat [structural motif]
    pfam12799
    Location:49 → 89
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:70 → 127
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    84161057..84190291
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515370.5 → XP_006515433.1  dynein axonemal light chain 1 isoform X1

    Conserved Domains (3) summary
    COG4886
    Location:24 → 141
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:37 → 58
    LRR_1; leucine-rich repeat [structural motif]
    sd00035
    Location:82 → 103
    LRR_NTF; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q05A62.2 GenPept UniProtKB/Swiss-Prot:Q05A62

Gene LinkOut

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