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CEACAM5 CEA cell adhesion molecule 5 [ Homo sapiens (human) ]

Gene ID: 1048, updated on 7-Apr-2024

Summary

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Official Symbol
CEACAM5provided by HGNC
Official Full Name
CEA cell adhesion molecule 5provided by HGNC
Primary source
HGNC:HGNC:1817
See related
Ensembl:ENSG00000105388 MIM:114890; AllianceGenome:HGNC:1817
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CEA; CD66e
Summary
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Expression
Biased expression in colon (RPKM 540.8), appendix (RPKM 102.3) and 2 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41708626..41730433)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44527954..44549792)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42212545..42234353)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372405 Neighboring gene CEA cell adhesion molecule 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10669 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10670 Neighboring gene uncharacterized LOC112268252 Neighboring gene CEA cell adhesion molecule 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:42282657-42283158 Neighboring gene CEA cell adhesion molecule 1 pseudogene Neighboring gene CEA cell adhesion molecule 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Identification of CEACAM5 as a stemness-related inhibitory immune checkpoint in pancreatic cancer. Shi H, et al. BMC Cancer, 2022 Dec 9. PMID 36494785, Free PMC Article
  2. CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial-mesenchymal transition via inhibiting MDM2. Wang X, et al. Clin Sci (Lond), 2022 Nov 30. PMID 36377775, Free PMC Article
  3. Serum carcinoembryonic antigen and carbohydrate antigen 19-9 as preoperative diagnostic biomarkers of extrahepatic bile duct cancer. Kim HS, et al. BJS Open, 2021 Nov 9. PMID 34935900, Free PMC Article
  4. Effect of triptolide and chemotherapy on carcinoembryonic and carbohydrate antigens levels and first-line treatment of recurrent nasopharyngeal carcinoma. Liu C, et al. Cell Mol Biol (Noisy-le-grand), 2021 Aug 31. PMID 34817331
  5. A highly-specific fully-human antibody and CAR-T cells targeting CD66e/CEACAM5 are cytotoxic for CD66e-expressing cancer cells in vitro and in vivo. Baek DS, et al. Cancer Lett, 2022 Jan 28. PMID 34740610

See all (290) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance.
    Title: Phenotypic screen of sixty-eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance.
  2. Detection and clinical significance of CEACAM5 methylation in colorectal cancer patients.
    Title: Detection and clinical significance of CEACAM5 methylation in colorectal cancer patients.
  3. Differential expression of carcinoembryonic antigen-related cell adhesion molecule-5 (CEACAM5) and dipeptidyl peptidase-4 (DPP4) with detection of Middle East respiratory syndrome-coronavirus in peripheral blood.
    Title: Differential expression of carcinoembryonic antigen-related cell adhesion molecule-5 (CEACAM5) and dipeptidyl peptidase-4 (DPP4) with detection of Middle East respiratory syndrome-coronavirus in peripheral blood.
  4. [Heterogeneity analysis of pancreatic cancer and identification of molecular subtypes of tumor cells based on CEACAM5, LGALS1 and CENPF gene expression].
    Title: [Heterogeneity analysis of pancreatic cancer and identification of molecular subtypes of tumor cells based on CEACAM5, LGALS1 and CENPF gene expression].
  5. Combination of CEACAM5, EpCAM and CK19 gene expressions in mediastinal lymph node micrometastasis is a prognostic factor for non-small cell lung cancer.
    Title: Combination of CEACAM5, EpCAM and CK19 gene expressions in mediastinal lymph node micrometastasis is a prognostic factor for non-small cell lung cancer.
  6. Identification of CEACAM5 as a stemness-related inhibitory immune checkpoint in pancreatic cancer.
    Title: Identification of CEACAM5 as a stemness-related inhibitory immune checkpoint in pancreatic cancer.
  7. CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial-mesenchymal transition via inhibiting MDM2.
    Title: CEACAM5 inhibits the lymphatic metastasis of head and neck squamous cell carcinoma by regulating epithelial-mesenchymal transition via inhibiting MDM2.
  8. Trajectories of Perioperative Serum Tumor Markers and Colorectal Cancer Outcomes: A Retrospective, Multicenter Longitudinal Cohort Study.
    Title: Trajectories of Perioperative Serum Tumor Markers and Colorectal Cancer Outcomes: A Retrospective, Multicenter Longitudinal Cohort Study.
  9. Serum carcinoembryonic antigen and carbohydrate antigen 19-9 as preoperative diagnostic biomarkers of extrahepatic bile duct cancer.
    Title: Serum carcinoembryonic antigen and carbohydrate antigen 19-9 as preoperative diagnostic biomarkers of extrahepatic bile duct cancer.
  10. Effect of triptolide and chemotherapy on carcinoembryonic and carbohydrate antigens levels and first-line treatment of recurrent nasopharyngeal carcinoma.
    Title: Effect of triptolide and chemotherapy on carcinoembryonic and carbohydrate antigens levels and first-line treatment of recurrent nasopharyngeal carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (245)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp781M2392

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GPI anchor binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of anoikis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of myotube differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface IC
Inferred by Curator
more info
 PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 5
Names
carcinoembryonic antigen related cell adhesion molecule 5
meconium antigen 100

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291484.3 → NP_001278413.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001278413.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' UTR compared to variant 1. Both variants 1 and 2 encode isoform 1.
    Source sequence(s)
    AC243967, AK223101, DB006625, M29540
    Consensus CDS
    CCDS12584.1
    UniProtKB/Swiss-Prot
    H9KVA7, P06731
    UniProtKB/TrEMBL
    A0A024R0K5, Q53G30, Q8N4D0
    Related
    ENSP00000385072.1, ENST00000405816.5
    Conserved Domains (5) summary
    cd05740
    Location:324 → 412
    Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:244 → 318
    IG_like; Immunoglobulin like
    pfam13895
    Location:240 → 318
    Ig_2; Immunoglobulin domain
    cl11960
    Location:502 → 590
    Ig; Immunoglobulin domain

  2. NM_001308398.2 → NP_001295327.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform 2 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site at an internal exon and differs in the 3' UTR compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AK223101, DB006625, X16455
    Consensus CDS
    CCDS77302.1
    UniProtKB/TrEMBL
    Q53G30, Q8N4D0
    Conserved Domains (5) summary
    cd05740
    Location:323 → 411
    Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:244 → 318
    IG_like; Immunoglobulin like
    pfam13895
    Location:240 → 318
    Ig_2; Immunoglobulin domain
    cl11960
    Location:501 → 589
    Ig; Immunoglobulin domain

  3. NM_004363.6 → NP_004354.3  carcinoembryonic antigen-related cell adhesion molecule 5 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_004354.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Both variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC243967, DB006625, M15042
    Consensus CDS
    CCDS12584.1
    UniProtKB/Swiss-Prot
    H9KVA7, P06731
    UniProtKB/TrEMBL
    A0A024R0K5, Q53G30, Q8N4D0
    Related
    ENSP00000221992.5, ENST00000221992.11
    Conserved Domains (5) summary
    cd05740
    Location:324 → 412
    Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:244 → 318
    IG_like; Immunoglobulin like
    pfam13895
    Location:240 → 318
    Ig_2; Immunoglobulin domain
    cl11960
    Location:502 → 590
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    41708626..41730433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026145.3 → XP_016881634.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform X1

    UniProtKB/TrEMBL
    Q53G30, Q8N4D0
    Related
    ENSP00000381600.4, ENST00000398599.8
    Conserved Domains (5) summary
    cd05740
    Location:323 → 411
    Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:244 → 318
    IG_like; Immunoglobulin like
    pfam13895
    Location:240 → 318
    Ig_2; Immunoglobulin domain
    cl11960
    Location:501 → 589
    Ig; Immunoglobulin domain

  2. XM_017026146.3 → XP_016881635.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform X2

    UniProtKB/TrEMBL
    Q53G30, Q8N4D0
    Related
    ENSP00000482157.1, ENST00000615021.4

  3. XM_011526322.3 → XP_011524624.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform X3

    UniProtKB/TrEMBL
    A0A087WYX0, T2HVB7
    Conserved Domains (5) summary
    cd05740
    Location:146 → 234
    Ig_CEACAM_D4; Fourth immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    cd05774
    Location:36 → 140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:244 → 318
    IG_like; Immunoglobulin like
    pfam13895
    Location:240 → 318
    Ig_2; Immunoglobulin domain
    cl11960
    Location:324 → 412
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    44527954..44549792
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319536.1 → XP_054175511.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform X1

  2. XM_054319537.1 → XP_054175512.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform X2

  3. XM_054319538.1 → XP_054175513.1  carcinoembryonic antigen-related cell adhesion molecule 5 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P06731.4 GenPept UniProtKB/Swiss-Prot:P06731

Gene LinkOut

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