MHRT myosin heavy chain associated RNA transcript [Homo sapiens (human)] - Gene

Summary

Official Symbol: MHRTprovided by HGNC
Official Full Name: myosin heavy chain associated RNA transcriptprovided by HGNC
Primary source: HGNC:HGNC:51291
See related: MIM:616096; AllianceGenome:HGNC:51291
Gene type: ncRNA
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Myheart
Summary: This gene encodes a spliced long non-coding RNA that may act as a cardioprotective agent in the heart. Based on a study of a similar gene in mouse, the encoded transcript may regulate chromatin remodeling by acting as a decoy to the BRG1 chromatin repressor complex thus preventing it from binding to its genomic targets. Blocking the actions of BRG1 could be crucial in protecting the heart from pathological hypertrophy. [provided by RefSeq, Dec 2014]
Expression: Restricted expression toward heart (RPKM 2213.9) See more
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Genomic context

Location:: 14q11.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (23415450..23417595)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (17616454..17618599)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (23884659..23886804)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Association of long-chain non-coding RNA MHRT gene single nucleotide polymorphism with risk and prognosis of chronic heart failure.
Title: Association of long-chain non-coding RNA MHRT gene single nucleotide polymorphism with risk and prognosis of chronic heart failure.
MHRT was ectopically expressed in gastric cancer tissues and cell lines. MHRT inhibits apoptosis and promotes proliferation and invasion of gastric cancer cells in vitro. MHRT inhibition of apoposis occurs via regulation of the expression of miR-4529-5p which then regulates expression of ROCK2.
Title: Myosin Heavy Chain-Associated RNA Transcripts Promotes Gastric Cancer Progression Through the miR-4529-5p/ROCK2 Axis.
lncRNAs MHRT, FENDRR and CARMEN show distinct expression profiles in hypertensive patients
Title: The long non-coding RNAs MHRT, FENDRR and CARMEN, their expression levels in peripheral blood mononuclear cells in patients with essential hypertension and their relation to heart hypertrophy.
elevation of circulating NRON and MHRT predicts heart failure (HF) and may be considered as novel biomarkers of HF.
Title: Circulating long non-coding RNAs NRON and MHRT as novel predictive biomarkers of heart failure.
Long noncoding Mhrt RNA: molecular crowbar unravel insights into heart failure treatment
Title: Long noncoding Mhrt RNA: molecular crowbar unravel insights into heart failure treatment.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein sequestering activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein sequestering activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in chromatin remodeling	TAS Traceable Author Statement more info	PubMed

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.