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LINC01224 long intergenic non-protein coding RNA 1224 [ Homo sapiens (human) ]

Gene ID: 104472717, updated on 10-Oct-2023

Summary

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Official Symbol
LINC01224provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 1224provided by HGNC
Primary source
HGNC:HGNC:49676
See related
Ensembl:ENSG00000269416 AllianceGenome:HGNC:49676
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in small intestine (RPKM 1.0), testis (RPKM 0.9) and 8 other tissues See more
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Genomic context

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Location:
19p12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (23399233..23416074, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (23537069..23553909, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (23582035..23598876, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 91 Neighboring gene CDC42 effector protein 3 pseudogene 1 Neighboring gene BCL2 interacting protein 3 pseudogene 8 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:23577675-23578543 Neighboring gene uncharacterized LOC105372335 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:23597843-23598500 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:23598501-23599156 Neighboring gene vomeronasal 1 receptor 92 pseudogene Neighboring gene uncharacterized LOC105372334

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Long Non-coding RNA LINC01224 Promotes the Malignant Behaviors of Triple Negative Breast Cancer Cells via Regulating the miR-193a-5p/NUP210 Axis. Sang K, et al. Mol Biotechnol, 2023 Apr. PMID 36127622
  2. LINC01224 promotes colorectal cancer progression through targeting miR-485-5p/MYO6 axis. Gu J, et al. World J Surg Oncol, 2021 Sep 17. PMID 34535152, Free PMC Article
  3. Long non-coding RNA LINC01224 promotes progression and cisplatin resistance in non-small lung cancer by sponging miR-2467. Xiao S, et al. Pulm Pharmacol Ther, 2021 Oct. PMID 34403779
  4. LINC01224 accelerates malignant transformation via MiR-193a-5p/CDK8 axis in gastric cancer. Sun H, et al. Cancer Med, 2021 Feb. PMID 33655711, Free PMC Article
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. Kimura K, et al. Genome Res, 2006 Jan. PMID 16344560, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long Non-coding RNA LINC01224 Promotes the Malignant Behaviors of Triple Negative Breast Cancer Cells via Regulating the miR-193a-5p/NUP210 Axis.
    Title: Long Non-coding RNA LINC01224 Promotes the Malignant Behaviors of Triple Negative Breast Cancer Cells via Regulating the miR-193a-5p/NUP210 Axis.
  2. Long non-coding RNA LINC01224 promotes progression and cisplatin resistance in non-small lung cancer by sponging miR-2467.
    Title: Long non-coding RNA LINC01224 promotes progression and cisplatin resistance in non-small lung cancer by sponging miR-2467.
  3. LINC01224 promotes colorectal cancer progression through targeting miR-485-5p/MYO6 axis.
    Title: LINC01224 promotes colorectal cancer progression through targeting miR-485-5p/MYO6 axis.
  4. LINC01224 accelerates malignant transformation via MiR-193a-5p/CDK8 axis in gastric cancer.
    Title: LINC01224 accelerates malignant transformation via MiR-193a-5p/CDK8 axis in gastric cancer.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Other Names

  • CTB-175P5.4

Clone Names

  • FLJ12731

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_126448.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC022409

  2. NR_126449.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon, resulting in a shorter transcript than variant 1.
    Source sequence(s)
    AC022409
    Related
    ENST00000600643.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    23399233..23416074 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    23537069..23553909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases