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LINC01228 long intergenic non-protein coding RNA 1228 [ Homo sapiens (human) ]

Gene ID: 104266962, updated on 10-Oct-2023

Summary

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Official Symbol
LINC01228provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 1228provided by HGNC
Primary source
HGNC:HGNC:49681
See related
AllianceGenome:HGNC:49681
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
lincRNA-DYNLRB2-2
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Genomic context

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Location:
16q23.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (79797835..79827150, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (85854375..85883685, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (79831732..79861047, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928230 Neighboring gene Sharpr-MPRA regulatory region 6091 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11159 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7737 Neighboring gene uncharacterized LOC105371356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:79742031-79742530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11160 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:79804516-79804714 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11161 Neighboring gene MAF transcriptional regulator RNA Neighboring gene long intergenic non-protein coding RNA 1229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11163 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11164 Neighboring gene HNF4 motif-containing MPRA enhancer 204/205 Neighboring gene Sharpr-MPRA regulatory region 4834 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11165 Neighboring gene NFE2L2 motif-containing MPRA enhancer 24 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:80006081-80006287 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:80060683-80061882 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr16:80078510-80079709 Neighboring gene uncharacterized LOC105371357 Neighboring gene uncharacterized LOC105371358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7739 Neighboring gene DYNLRB2 antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr16:80231288-80232487 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:80255087-80255329 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7740 Neighboring gene Sharpr-MPRA regulatory region 10203 Neighboring gene Sharpr-MPRA regulatory region 10573 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:80351553-80352053 Neighboring gene VISTA enhancer hs4 Neighboring gene HNF1 motif-containing MPRA enhancer 101 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:80499762-80500344 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr16:80500345-80500926 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7741 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7742 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11167 Neighboring gene dynein light chain roadblock-type 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LincRNA DYN-LRB2-2 upregulates cholesterol efflux by decreasing TLR2 expression in macrophages. Li Y, et al. J Cell Biochem, 2018 Feb. PMID 28815701
  2. A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis. Hu YW, et al. J Lipid Res, 2014 Apr. PMID 24493833, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results show that LincRNA DYN-LRB2-2 upregulates cholesterol efflux by decreasing TLR2 expression in macrophages.
    Title: LincRNA DYN-LRB2-2 upregulates cholesterol efflux by decreasing TLR2 expression in macrophages.
  2. Oxidized-LDL significantly induces lincRNA-DYNLRB2-2 expression, which promotes ABCA1-mediated cholesterol efflux and inhibits inflammation through GPR119 in THP-1 cells.
    Title: A lincRNA-DYNLRB2-2/GPR119/GLP-1R/ABCA1-dependent signal transduction pathway is essential for the regulation of cholesterol homeostasis.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_170199.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087188, AC113931

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    79797835..79827150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    85854375..85883685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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