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Tsp2 tumor suppressor region 2 [ Mus musculus (house mouse) ]

Gene ID: 104266, updated on 17-Aug-2024

Summary

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Official Symbol
Tsp2provided by MGI
Official Full Name
tumor suppressor region 2provided by MGI
Primary source
MGI:MGI:106194
Gene type
other
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MTS
Annotation information
not in current annotation release
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Genomic context

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Location:
chromosome: 4

Bibliography

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Related articles in PubMed

  1. Thrombospondin-2 regulates matrix mineralization in MC3T3-E1 pre-osteoblasts. Alford AI, et al. Bone, 2010 Feb. PMID 19744582, Free PMC Article
  2. Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing. Taylor DK, et al. J Bone Miner Res, 2009 Jun. PMID 19123916, Free PMC Article
  3. Mice lacking thrombospondin 2 show an atypical pattern of endocortical and periosteal bone formation in response to mechanical loading. Hankenson KD, et al. Bone, 2006 Mar. PMID 16290255
  4. Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function. Bancroft T, et al. J Biol Chem, 2015 Jan 2. PMID 25389299, Free PMC Article
  5. Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo. Chen J, et al. Nat Med, 2005 Nov. PMID 16227992, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Repression of TSP2 expression is a critical aspect of Akt1 function in tissue repair.
    Title: Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function.
  2. TSP2 and TSP1/TSP2 KO mice showed elevated auditory brainstem response thresholds.
    Title: Thrombospondins 1 and 2 are important for afferent synapse formation and function in the inner ear.
  3. TSP2 is involved in the modulation of NF-kappaB activity and attenuation of angiogenesis.
    Title: Cyp1B1 expression promotes angiogenesis by suppressing NF-κB activity.
  4. LRP1 and TSP2 stimulate Notch activity by driving trans-endocytosis of the Notch ectodomain into the signal-sending cell
    Title: Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling.
  5. TSP2 may promote mineralization, by facilitating proper organization of the osteoblast-derived extracellular matrix.
    Title: Thrombospondin-2 regulates matrix mineralization in MC3T3-E1 pre-osteoblasts.
  6. by expressing TSP2 using adenovirus starting 3 days after fracture, chondrogenesis was restored in TSP2-null mice. We hypothesize that TSP2 expressed by cells in the fracture mesenchyme regulates callus vascularization
    Title: Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing.
  7. Mice lacking Tsp2 show an atypical pattern of endocortical and periosteal bone formation in response to mechanical loading.
    Title: Mice lacking thrombospondin 2 show an atypical pattern of endocortical and periosteal bone formation in response to mechanical loading.
  8. Re-expression of TSP2 in mice transplanted with wild-type bone marrow corrected the angiogenic abnormalities in Akt1(-/-) mice.
    Title: Akt1 regulates pathological angiogenesis, vascular maturation and permeability in vivo.
  9. EWS/FLI1 has a role in regulating tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins TSP1 and TSP2
    Title: EWS/FLI1 regulates tumor angiogenesis in Ewing's sarcoma via suppression of thrombospondins.
Submit: New GeneRIF Correction

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