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CBL Cbl proto-oncogene [ Aptenodytes forsteri (emperor penguin) ]

Gene ID: 103906116, updated on 3-Aug-2024

Summary

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Gene symbol
CBL
Gene description
Cbl proto-oncogene
Locus tag
AS27_15116
Gene type
protein coding
RefSeq status
MODEL
Organism
Aptenodytes forsteri
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Neoaves; Aequornithes; Sphenisciformes; Spheniscidae; Aptenodytes
Orthologs
human mouse all
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Genomic context

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See CBL in Genome Data Viewer
Location:
chromosome: Un
Exon count:
15
Annotation release Status Assembly Chr Location
101 current ASM69914v1 (GCF_000699145.1) Unplaced Scaffold NW_008796189.1 (96086..129718, complement)

NW_008796189.1Genomic Context describing neighboring genes Neighboring gene C1q and TNF related 5 Neighboring gene ring finger protein 26 Neighboring gene melanoma cell adhesion molecule Neighboring gene dynein regulatory complex subunit 12 homolog Neighboring gene NHERF family PDZ scaffold protein 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_008796189.1 Unplaced Scaffold Reference ASM69914v1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphotyrosine residue binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of epidermal growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase CBL

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Aptenodytes forsteri Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM69914v1

Genomic

  1. NW_008796189.1 Reference ASM69914v1

    Range
    96086..129718 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009287955.2 → XP_009286230.1  E3 ubiquitin-protein ligase CBL

    UniProtKB/TrEMBL
    A0A087RIR8
    Conserved Domains (5) summary
    cd09920
    Location:151 → 247
    SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
    cd00162
    Location:276 → 318
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd14393
    Location:765 → 804
    UBA_c-Cbl; UBA domain found in E3 ubiquitin-protein ligase Cbl and similar proteins
    pfam02262
    Location:1 → 70
    Cbl_N; CBL proto-oncogene N-terminal domain 1
    pfam02761
    Location:74 → 157
    Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
Nucleotide Protein
Heading Accession and Version

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