FOXC2-AS1 FOXC2 antisense RNA 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FOXC2-AS1provided by HGNC
Official Full Name: FOXC2 antisense RNA 1provided by HGNC
Primary source: HGNC:HGNC:50665
See related: AllianceGenome:HGNC:50665
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ODRUL
Expression: Broad expression in kidney (RPKM 1.2), testis (RPKM 0.8) and 15 other tissues See more
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Genomic context

Location:: 16q24.1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (86565145..86567761, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (92633462..92636078, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (86598751..86601367, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FOXC2-AS1/FOXC2 axis mediates matrix stiffness-induced trans-differentiation of hepatic stellate cells into fibrosis-promoting myofibroblasts.
Title: FOXC2-AS1/FOXC2 axis mediates matrix stiffness-induced trans-differentiation of hepatic stellate cells into fibrosis-promoting myofibroblasts.
LncRNA ODRUL regulates progression of osteosarcoma by regulating IL-6 via sponging miR-6874-3p.
Title: LncRNA ODRUL regulates progression of osteosarcoma by regulating IL-6 via sponging miR-6874-3p.
H3K27ac-induced FOXC2-AS1 accelerates tongue squamous cell carcinoma by upregulating E2F3.
Title: H3K27ac-induced FOXC2-AS1 accelerates tongue squamous cell carcinoma by upregulating E2F3.
LncRNA FOXC2-AS1 stimulates proliferation of melanoma via silencing p15 by recruiting EZH2.
Title: LncRNA FOXC2-AS1 stimulates proliferation of melanoma via silencing p15 by recruiting EZH2.
LncRNA FOXC2-AS1 enhances FOXC2 mRNA stability to promote colorectal cancer progression via activation of Ca(2+)-FAK signal pathway.
Title: LncRNA FOXC2-AS1 enhances FOXC2 mRNA stability to promote colorectal cancer progression via activation of Ca(2+)-FAK signal pathway.
Expression level of FOXC2-AS1 in lung cancer (LCa) specimens was considerably higher than in normal tissues and correlated with higher incidence of distant metastasis and lower overall survival rate. miR-107 expression was found significantly reduced in LCa cell lines and tissues and showed a negative correlation with FOXC2-AS1. Luciferase reporter gene assay verified direct binding of FOXC2-AS1 to downstream miRNA-107.
Title: Mechanism of LncRNA FOXC2-AC1 promoting lung cancer metastasis by regulating miR-107.
a high level of FOXC2-AS1 was associated with poor prognosis of BC patients.
Title: Long Noncoding RNA FOXC2-AS1 Predicts Poor Survival in Breast Cancer Patients and Promotes Cell Proliferation.
lncRNA FOXC2-AS1 accelerated the tumor progression of prostate cancer cells by regulating the proliferation and tumor growth through miR-1253/EZH2 axis.
Title: Long noncoding RNA FOXC2-AS1 facilitates the proliferation and progression of prostate cancer via targeting miR-1253/EZH2.
Nrf2-mediated lncRNA ODRUL was indispensable for silver nanoparticle-induced toxicity in erythroid cells.
Title: Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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General gene information

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Other Names

osteosarcoma doxorubicin-resistance related up-regulated lncRNA
osteosarcoma doxorubicin-resistance related upregulated lncRNA

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.