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CAPN3 calpain 3 [ Galeopterus variegatus (Sunda flying lemur) ]

Gene ID: 103600898, updated on 11-Mar-2024

Summary

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Gene symbol
CAPN3
Gene description
calpain 3
Gene type
protein coding
RefSeq status
MODEL
Organism
Galeopterus variegatus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Dermoptera; Cynocephalidae; Galeopterus
Orthologs
human mouse all
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Genomic context

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See CAPN3 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
25
Annotation release Status Assembly Chr Location
100 current G_variegatus-3.0.2 (GCF_000696425.1) Unplaced Scaffold NW_007729615.1 (30737..91669)

NW_007729615.1Genomic Context describing neighboring genes Neighboring gene neutral alpha-glucosidase C Neighboring gene uncharacterized LOC103600899 Neighboring gene zinc finger protein 106 Neighboring gene GPI-anchor transamidase pseudogene

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_007729615 unplaced scaffold reference G_variegatus-3.0.2 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Galeopterus variegatus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference G_variegatus-3.0.2 Primary Assembly

Genomic

  1. NW_007729615.1 Reference G_variegatus-3.0.2 Primary Assembly

    Range
    30737..91669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008585231.1 → XP_008583453.1  calpain-3 isoform X1

    Conserved Domains (6) summary
    cd00051
    Location:696 → 750
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77 → 414
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:428 → 578
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:727 → 783
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:582 → 651
    Calpain_u2; Unstructured region on Calpain-3
    cl08302
    Location:727 → 816
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_008585234.1 → XP_008583456.1  calpain-3 isoform X4

    Conserved Domains (5) summary
    PTZ00184
    Location:553 → 691
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:605 → 659
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77 → 367
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:381 → 531
    Calpain_III; Calpain large subunit, domain III
    cl08302
    Location:636 → 725
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. XM_008585232.1 → XP_008583454.1  calpain-3 isoform X2

    Conserved Domains (6) summary
    cd00051
    Location:690 → 744
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:77 → 414
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:428 → 578
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:721 → 777
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:582 → 645
    Calpain_u2; Unstructured region on Calpain-3
    cl08302
    Location:721 → 810
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. XM_008585235.1 → XP_008583457.1  calpain-3 isoform X5

    Conserved Domains (5) summary
    PTZ00184
    Location:533 → 671
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:585 → 639
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:51 → 347
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:361 → 511
    Calpain_III; Calpain large subunit, domain III
    cl08302
    Location:616 → 705
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  5. XM_008585233.1 → XP_008583455.1  calpain-3 isoform X3

    Conserved Domains (5) summary
    cd00051
    Location:632 → 686
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:51 → 394
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:408 → 558
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:663 → 719
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:663 → 752
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
Heading Accession and Version

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