U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PCGF3 polycomb group ring finger 3 [ Homo sapiens (human) ]

Gene ID: 10336, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
PCGF3provided by HGNC
Official Full Name
polycomb group ring finger 3provided by HGNC
Primary source
HGNC:HGNC:10066
See related
Ensembl:ENSG00000185619 MIM:617543; AllianceGenome:HGNC:10066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF3; DONG1; RNF3A
Summary
The protein encoded by this gene contains a C3HC4 type RING finger, which is a motif known to be involved in protein-protein interactions. The specific function of this protein has not yet been determined. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in skin (RPKM 24.1), endometrium (RPKM 13.1) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
4p16.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (705832..770089)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (705458..767880)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (699621..763877)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:668197-668954 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:674515-675154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15102 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15103 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21131 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:680358-681306 Neighboring gene uncharacterized LOC124900643 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:682255-683203 Neighboring gene solute carrier family 49 member 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:683204-684151 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:686336-686923 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:686924-687510 Neighboring gene myosin light chain 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:688618-689118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:694583-695083 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:697641-698368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:699409-700394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:700395-701379 Neighboring gene uncharacterized LOC124900172 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:720375-720890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:720891-721405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:725234-725734 Neighboring gene uncharacterized LOC107986246 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15107 Neighboring gene uncharacterized LOC124900644 Neighboring gene chloride intracellular channel protein 6-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:759135-759682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21134 Neighboring gene PCGF3 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:762535-763476 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:774752-775469 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:775470-776186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:776187-776904 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:778899-779770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:781743-782244 Neighboring gene uncharacterized LOC105374339 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:782245-782744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:783251-783750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:784983-785792 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15110 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21135 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21137 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:793259-793758 Neighboring gene complexin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15111 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:823745-824262 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:824263-824778 Neighboring gene uncharacterized LOC105374340

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. PCGF3 promotes the proliferation and migration of non-small cell lung cancer cells via the PI3K/AKT signaling pathway. Hu Y, et al. Exp Cell Res, 2021 Mar 15. PMID 33485844
  2. PNPT1 and PCGF3 variants associated with angiotensin-converting enzyme inhibitor-induced cough: a nested case-control genome-wide study. Mu G, et al. Pharmacogenomics, 2020 Jun. PMID 32397904
  3. Extratelomeric Binding of the Telomere Binding Protein TRF2 at the PCGF3 Promoter Is G-Quadruplex Motif-Dependent. Purohit G, et al. Biochemistry, 2018 Apr 24. PMID 29589913
  4. KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1. Wong SJ, et al. Structure, 2016 Oct 4. PMID 27568929, Free PMC Article
  5. Functional redundancy among Polycomb complexes in maintaining the pluripotent state of embryonic stem cells. Zhu Y, et al. Stem Cell Reports, 2022 May 10. PMID 35364009, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PCGF3 promotes the proliferation and migration of non-small cell lung cancer cells via the PI3K/AKT signaling pathway.
    Title: PCGF3 promotes the proliferation and migration of non-small cell lung cancer cells via the PI3K/AKT signaling pathway.
  2. PNPT1 and PCGF3 variants associated with angiotensin-converting enzyme inhibitor-induced cough: a nested case-control genome-wide study.
    Title: PNPT1 and PCGF3 variants associated with angiotensin-converting enzyme inhibitor-induced cough: a nested case-control genome-wide study.
  3. We demonstrate that promoter binding by TRF2 mediates PCGF3 promoter activity, and both the N-terminal and C-terminal domains of TRF2 are necessary for promoter activity.
    Title: Extratelomeric Binding of the Telomere Binding Protein TRF2 at the PCGF3 Promoter Is G-Quadruplex Motif-Dependent.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ36550, FLJ43813, MGC40413, MGC129615, DKFZp686D20235

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone H2AK119 ubiquitin ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in random inactivation of X chromosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of PRC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of PcG protein complex IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with X chromosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
polycomb group RING finger protein 3
Names
RING finger protein 3A
ring finger protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317836.3 → NP_001304765.1  polycomb group RING finger protein 3 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1-7 all encode the same isoform (a).
    Source sequence(s)
    AC107464, AC139887
    Consensus CDS
    CCDS3339.2
    UniProtKB/Swiss-Prot
    D3DVN1, O15262, Q3KNV8
    UniProtKB/TrEMBL
    B3KQ06
    Conserved Domains (2) summary
    cd16735
    Location:14 → 60
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:154 → 236
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

  2. NM_001395245.1 → NP_001382174.1  polycomb group RING finger protein 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC107464, AC139887
    Consensus CDS
    CCDS3339.2
    UniProtKB/Swiss-Prot
    D3DVN1, O15262, Q3KNV8
    UniProtKB/TrEMBL
    B3KQ06
    Conserved Domains (2) summary
    cd16735
    Location:14 → 60
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:154 → 236
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

  3. NM_001395246.1 → NP_001382175.1  polycomb group RING finger protein 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC107464, AC139887
    Consensus CDS
    CCDS3339.2
    UniProtKB/Swiss-Prot
    D3DVN1, O15262, Q3KNV8
    UniProtKB/TrEMBL
    B3KQ06
    Conserved Domains (2) summary
    cd16735
    Location:14 → 60
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:154 → 236
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

  4. NM_001395247.1 → NP_001382176.1  polycomb group RING finger protein 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC107464, AC139887
    Consensus CDS
    CCDS3339.2
    UniProtKB/Swiss-Prot
    D3DVN1, O15262, Q3KNV8
    UniProtKB/TrEMBL
    B3KQ06
    Conserved Domains (2) summary
    cd16735
    Location:14 → 60
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:154 → 236
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

  5. NM_001395248.1 → NP_001382177.1  polycomb group RING finger protein 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC107464, AC139887
    Consensus CDS
    CCDS3339.2
    UniProtKB/Swiss-Prot
    D3DVN1, O15262, Q3KNV8
    UniProtKB/TrEMBL
    B3KQ06
    Conserved Domains (2) summary
    cd16735
    Location:14 → 60
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:154 → 236
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

  6. NM_001395249.1 → NP_001382178.1  polycomb group RING finger protein 3 isoform a

    Status: REVIEWED

    Source sequence(s)
    AC107464, AC139887
    Consensus CDS
    CCDS3339.2
    UniProtKB/Swiss-Prot
    D3DVN1, O15262, Q3KNV8
    UniProtKB/TrEMBL
    B3KQ06
    Conserved Domains (2) summary
    cd16735
    Location:14 → 60
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:154 → 236
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

  7. NM_001395250.1 → NP_001382179.1  polycomb group RING finger protein 3 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC107464, AC139887
    UniProtKB/TrEMBL
    B3KQ06, B3KWT8
    Conserved Domains (2) summary
    cd17083
    Location:120 → 202
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cl17238
    Location:2 → 26
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  8. NM_001395251.1 → NP_001382180.1  polycomb group RING finger protein 3 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC107464, AC139887
    UniProtKB/TrEMBL
    B3KQ06, B3KWT8
    Conserved Domains (2) summary
    cd17083
    Location:120 → 202
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cl17238
    Location:2 → 26
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

  9. NM_006315.7 → NP_006306.2  polycomb group RING finger protein 3 isoform a

    See identical proteins and their annotated locations for NP_006306.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' UTR compared to variant 1. Variants 1-7 all encode the same isoform (a).
    Source sequence(s)
    AC107464, AC139887
    Consensus CDS
    CCDS3339.2
    UniProtKB/Swiss-Prot
    D3DVN1, O15262, Q3KNV8
    UniProtKB/TrEMBL
    B3KQ06
    Related
    ENSP00000354724.5, ENST00000362003.10
    Conserved Domains (2) summary
    cd16735
    Location:14 → 60
    RING-HC_PCGF3; RING finger found in polycomb group RING finger protein 3 (PCGF3) and similar proteins
    cd17083
    Location:154 → 236
    RAWUL_PCGF3; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 3 (PCGF3) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    705832..770089
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047449500.1 → XP_047305456.1  polycomb group RING finger protein 3 isoform X1

    UniProtKB/TrEMBL
    B3KWT8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    705458..767880
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348726.1 → XP_054204701.1  polycomb group RING finger protein 3 isoform X1

    UniProtKB/TrEMBL
    B3KWT8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KNV8.1 GenPept UniProtKB/Swiss-Prot:Q3KNV8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous