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CAPN3 calpain 3 [ Carlito syrichta (Philippine tarsier) ]

Gene ID: 103261776, updated on 11-Mar-2024

Summary

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Gene symbol
CAPN3
Gene description
calpain 3
See related
Ensembl:ENSTSYG00000004149
Gene type
protein coding
RefSeq status
MODEL
Organism
Carlito syrichta
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Tarsiiformes; Tarsiidae; Carlito
Orthologs
human mouse all
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Genomic context

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See CAPN3 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
27
Annotation release Status Assembly Chr Location
101 current Tarsius_syrichta-2.0.1 (GCF_000164805.1) Unplaced Scaffold NW_007035658.1 (356868..412455, complement)

NW_007035658.1Genomic Context describing neighboring genes Neighboring gene synaptosome associated protein 23 Neighboring gene zinc finger protein 106 Neighboring gene glucosidase alpha, neutral C Neighboring gene transmembrane protein 87A Neighboring gene VPS39 subunit of HOPS complex

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_007035658 Unplaced Scaffold Reference Tarsius_syrichta-2.0.1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium-dependent cysteine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
calpain-3

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Carlito syrichta Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Tarsius_syrichta-2.0.1 Primary Assembly

Genomic

  1. NW_007035658.1 Reference Tarsius_syrichta-2.0.1 Primary Assembly

    Range
    356868..412455 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008059377.2 → XP_008057568.1  calpain-3 isoform X4

    UniProtKB/TrEMBL
    A0A1U7TMF0
    Conserved Domains (5) summary
    cd00051
    Location:605 → 659
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:75 → 367
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:381 → 531
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:636 → 692
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:636 → 725
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  2. XM_008059366.2 → XP_008057557.1  calpain-3 isoform X2

    UniProtKB/TrEMBL
    A0A1U7TWV9
    Related
    ENSTSYP00000003812.2, ENSTSYT00000004163.2
    Conserved Domains (6) summary
    cd00051
    Location:691 → 745
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:75 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:429 → 579
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:722 → 778
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:583 → 647
    Calpain_u2; Unstructured region on Calpain-3
    cl08302
    Location:722 → 811
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  3. XM_008059362.2 → XP_008057553.1  calpain-3 isoform X1

    UniProtKB/TrEMBL
    A0A1U7TMD3
    Related
    ENSTSYP00000023493.1, ENSTSYT00000031910.1
    Conserved Domains (6) summary
    cd00051
    Location:697 → 751
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:75 → 415
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:429 → 579
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:728 → 784
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:583 → 653
    Calpain_u2; Unstructured region on Calpain-3
    cl08302
    Location:653 → 721
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  4. XM_008059412.1 → XP_008057603.1  calpain-3 isoform X8

    UniProtKB/TrEMBL
    A0A1U7TMI5
    Conserved Domains (5) summary
    cd00051
    Location:289 → 343
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01067
    Location:65 → 215
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:320 → 376
    EF-hand_7; EF-hand domain pair
    cl00051
    Location:8 → 61
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cl08302
    Location:245 → 313
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  5. XM_008059401.1 → XP_008057592.1  calpain-3 isoform X7

    UniProtKB/TrEMBL
    A0A1U7TWZ1
    Conserved Domains (6) summary
    cd00051
    Location:327 → 381
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01067
    Location:65 → 215
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:358 → 414
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:219 → 283
    Calpain_u2; Unstructured region on Calpain-3
    cl00051
    Location:8 → 61
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cl08302
    Location:283 → 351
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  6. XM_008059390.1 → XP_008057581.1  calpain-3 isoform X6

    See identical proteins and their annotated locations for XP_008057581.1

    UniProtKB/TrEMBL
    A0A1U7TV82
    Conserved Domains (6) summary
    cd00051
    Location:333 → 387
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01067
    Location:65 → 215
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:364 → 420
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:219 → 289
    Calpain_u2; Unstructured region on Calpain-3
    cl00051
    Location:8 → 61
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cl08302
    Location:289 → 357
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  7. XM_008059382.2 → XP_008057573.1  calpain-3 isoform X5

    UniProtKB/TrEMBL
    A0A1U7TMF8
    Conserved Domains (5) summary
    cd00051
    Location:585 → 639
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:51 → 347
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:361 → 511
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:616 → 672
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:541 → 609
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  8. XM_008059371.2 → XP_008057562.1  calpain-3 isoform X3

    UniProtKB/TrEMBL
    A0A1U7TWW4
    Related
    ENSTSYP00000022989.1, ENSTSYT00000045862.1
    Conserved Domains (5) summary
    cd00051
    Location:633 → 687
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam00648
    Location:51 → 395
    Peptidase_C2; Calpain family cysteine protease
    pfam01067
    Location:409 → 559
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:664 → 720
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:589 → 657
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  9. XM_008059396.2 → XP_008057587.1  calpain-3 isoform X6

    See identical proteins and their annotated locations for XP_008057587.1

    UniProtKB/TrEMBL
    A0A1U7TV82
    Conserved Domains (6) summary
    cd00051
    Location:333 → 387
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01067
    Location:65 → 215
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:364 → 420
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:219 → 289
    Calpain_u2; Unstructured region on Calpain-3
    cl00051
    Location:8 → 61
    CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
    cl08302
    Location:289 → 357
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  10. XM_008059420.1 → XP_008057611.1  calpain-3 isoform X9

    UniProtKB/TrEMBL
    A0A1U7TVB0
    Conserved Domains (5) summary
    cd00051
    Location:185 → 239
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01067
    Location:1 → 67
    Calpain_III; Calpain large subunit, domain III
    pfam13499
    Location:216 → 272
    EF-hand_7; EF-hand domain pair
    pfam16648
    Location:71 → 141
    Calpain_u2; Unstructured region on Calpain-3
    cl08302
    Location:141 → 209
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

  11. XM_021713006.1 → XP_021568681.1  calpain-3 isoform X10

    UniProtKB/TrEMBL
    A0A3Q0DZM4
    Related
    ENSTSYP00000017450.1, ENSTSYT00000048751.1
    Conserved Domains (2) summary
    cd15897
    Location:31 → 60
    EFh_PEF; EF-hand motif [structural motif]
    cl25352
    Location:1 → 156
    EFh_PEF; The penta-EF hand (PEF) family
Nucleotide Protein
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