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PLCB2 phospholipase C beta 2 [ Chlorocebus sabaeus (green monkey) ]

Gene ID: 103245842, updated on 11-Mar-2024

Summary

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Gene symbol
PLCB2
Gene description
phospholipase C beta 2
See related
Ensembl:ENSCSAG00000007432
Gene type
protein coding
RefSeq status
MODEL
Organism
Chlorocebus sabaeus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus
Orthologs
human mouse all
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Genomic context

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See PLCB2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
32
Annotation release Status Assembly Chr Location
102 current Vero_WHO_p1.0 (GCF_015252025.1) Unplaced Scaffold NW_023666048.1 (98236858..98257092, complement)
100 previous assembly Chlorocebus_sabeus 1.1 (GCF_000409795.2) 26 NC_023667.1 (42706462..42727516)

NW_023666048.1Genomic Context describing neighboring genes Neighboring gene p21 (RAC1) activated kinase 6 Neighboring gene chromosome 26 C15orf56 homolog Neighboring gene ankyrin repeat domain 63 Neighboring gene 60S acidic ribosomal protein P0-like Neighboring gene InaF motif containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Chlorocebus sabaeus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Vero_WHO_p1.0

Genomic

  1. NW_023666048.1 Reference Vero_WHO_p1.0

    Range
    98236858..98257092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008017045.2 → XP_008015236.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2

    Conserved Domains (8) summary
    cd00275
    Location:677 → 798
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 645
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    PLN02222
    Location:219 → 796
    PLN02222; phosphoinositide phospholipase C 2
    cd13361
    Location:17 → 144
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam08703
    Location:975 → 1149
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:220 → 311
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd16269
    Location:1100 → 1110
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:982 → 1137
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. XM_008017046.2 → XP_008015237.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3

    Conserved Domains (8) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    PLN02222
    Location:219 → 800
    PLN02222; phosphoinositide phospholipase C 2
    cd13361
    Location:17 → 144
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam08703
    Location:964 → 1138
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:220 → 311
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd16269
    Location:1089 → 1099
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:971 → 1126
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. XM_008017043.2 → XP_008015234.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1

    UniProtKB/TrEMBL
    A0A0D9R4V3
    Related
    ENSCSAP00000003642.1
    Conserved Domains (8) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    PLN02222
    Location:219 → 800
    PLN02222; phosphoinositide phospholipase C 2
    cd13361
    Location:17 → 144
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam08703
    Location:979 → 1153
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:220 → 311
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd16269
    Location:1104 → 1114
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:986 → 1141
    GBP_C; Guanylate-binding protein, C-terminal domain

  4. XM_008017048.2 → XP_008015239.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4

    See identical proteins and their annotated locations for XP_008015239.1

    Conserved Domains (8) summary
    cd00275
    Location:626 → 747
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:256 → 594
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    PLN02222
    Location:164 → 745
    PLN02222; phosphoinositide phospholipase C 2
    cd13361
    Location:1 → 89
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam08703
    Location:924 → 1098
    PLC-beta_C; PLC-beta C terminal
    pfam09279
    Location:165 → 256
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cd16269
    Location:1049 → 1059
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:931 → 1086
    GBP_C; Guanylate-binding protein, C-terminal domain

  5. XM_008017054.2 → XP_008015245.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X5

    See identical proteins and their annotated locations for XP_008015245.1

    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    PLN02222
    Location:219 → 800
    PLN02222; phosphoinositide phospholipase C 2
    cd13361
    Location:17 → 144
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam09279
    Location:220 → 311
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

  6. XM_008017055.2 → XP_008015246.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X5

    See identical proteins and their annotated locations for XP_008015246.1

    Conserved Domains (5) summary
    cd00275
    Location:681 → 802
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08624
    Location:311 → 649
    PI-PLCc_beta2; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-beta2
    PLN02222
    Location:219 → 800
    PLN02222; phosphoinositide phospholipase C 2
    cd13361
    Location:17 → 144
    PH_PLC_beta; Phospholipase C-beta (PLC-beta) pleckstrin homology (PH) domain
    pfam09279
    Location:220 → 311
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like

RNA

  1. XR_005244286.1 RNA Sequence

  2. XR_005244287.1 RNA Sequence

  3. XR_005244288.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version

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