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PIK3C2A phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha [ Chlorocebus sabaeus (green monkey) ]

Gene ID: 103242212, updated on 11-Mar-2024

Summary

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Gene symbol
PIK3C2A
Gene description
phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
See related
Ensembl:ENSCSAG00000004784
Gene type
protein coding
RefSeq status
MODEL
Organism
Chlorocebus sabaeus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus
Orthologs
human mouse all
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Genomic context

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See PIK3C2A in Genome Data Viewer
Location:
chromosome: Un
Exon count:
33
Annotation release Status Assembly Chr Location
102 current Vero_WHO_p1.0 (GCF_015252025.1) Unplaced Scaffold NW_023666038.1 (145200659..145318077)
100 previous assembly Chlorocebus_sabeus 1.1 (GCF_000409795.2) 1 NC_023642.1 (47759850..47874458)

NW_023666038.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103239560 Neighboring gene nucleobindin 2 Neighboring gene U6 spliceosomal RNA Neighboring gene small nucleolar RNA SNORD14 Neighboring gene small nucleolar RNA SNORD14 Neighboring gene ribosomal protein S13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phosphatidylinositol-mediated signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of phosphatidylinositol 3-kinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Chlorocebus sabaeus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Vero_WHO_p1.0

Genomic

  1. NW_023666038.1 Reference Vero_WHO_p1.0

    Range
    145200659..145318077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_037999644.1 → XP_037855572.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

    UniProtKB/TrEMBL
    A0A0D9QXK4
    Conserved Domains (6) summary
    cd07289
    Location:1426 → 1534
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:677 → 849
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1560 → 1681
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:870 → 1038
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cd05176
    Location:1043 → 1395
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:409 → 512
    PI3K_rbd; PI3-kinase family, ras-binding domain

  2. XM_037999645.1 → XP_037855573.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2

    UniProtKB/TrEMBL
    A0A0D9QXK4
    Conserved Domains (6) summary
    cd07289
    Location:1370 → 1478
    PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases
    cd04012
    Location:677 → 793
    C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd08381
    Location:1504 → 1625
    C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
    cd00869
    Location:814 → 982
    PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
    cd05176
    Location:987 → 1339
    PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha
    pfam00794
    Location:409 → 512
    PI3K_rbd; PI3-kinase family, ras-binding domain
Nucleotide Protein
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