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HSPG2 heparan sulfate proteoglycan 2 [ Chlorocebus sabaeus (green monkey) ]

Gene ID: 103225428, updated on 11-Mar-2024

Summary

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Gene symbol
HSPG2
Gene description
heparan sulfate proteoglycan 2
See related
Ensembl:ENSCSAG00000000907
Gene type
protein coding
RefSeq status
MODEL
Organism
Chlorocebus sabaeus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Chlorocebus
Orthologs
human mouse all
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Genomic context

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See HSPG2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
98
Annotation release Status Assembly Chr Location
102 current Vero_WHO_p1.0 (GCF_015252025.1) Unplaced Scaffold NW_023666033.1 (5486539..5602022, complement)
100 previous assembly Chlorocebus_sabeus 1.1 (GCF_000409795.2) 20 NC_023661.1 (110693858..110809467)

NW_023666033.1Genomic Context describing neighboring genes Neighboring gene RAP1 GTPase activating protein Neighboring gene ubiquitin specific peptidase 48 Neighboring gene U7 small nuclear RNA Neighboring gene low density lipoprotein receptor class A domain containing 2 Neighboring gene 60S ribosomal protein L31-like Neighboring gene U6 spliceosomal RNA Neighboring gene chymotrypsin like elastase 3B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
basement membrane-specific heparan sulfate proteoglycan core protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Chlorocebus sabaeus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Vero_WHO_p1.0

Genomic

  1. NW_023666033.1 Reference Vero_WHO_p1.0

    Range
    5486539..5602022 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038001292.1 → XP_037857220.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X2

    UniProtKB/TrEMBL
    A0A0D9S8B1
    Conserved Domains (16) summary
    cd05743
    Location:438 → 515
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00200
    Location:80 → 193
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:1002 → 1129
    LamB; Laminin B domain
    smart00409
    Location:2175 → 2252
    IG; Immunoglobulin
    smart00410
    Location:2074 → 2151
    IG_like; Immunoglobulin like
    cd00054
    Location:3869 → 3898
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1175 → 1224
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4220 → 4379
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:302 → 336
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4125 → 4155
    EGF; EGF-like domain
    pfam00052
    Location:1413 → 1545
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1292 → 1339
    Laminin_EGF; Laminin EGF domain
    pfam07679
    Location:3598 → 3675
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:3595 → 3598
    Ig; Ig strand A [structural motif]
    cd05754
    Location:1788 → 1873
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:3422 → 3500
    Ig; Immunoglobulin domain

  2. XM_007980126.2 → XP_007978317.2  basement membrane-specific heparan sulfate proteoglycan core protein isoform X1

    UniProtKB/TrEMBL
    A0A0D9S8B1
    Conserved Domains (16) summary
    cd05743
    Location:438 → 515
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00200
    Location:80 → 193
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:1003 → 1130
    LamB; Laminin B domain
    smart00409
    Location:2176 → 2253
    IG; Immunoglobulin
    smart00410
    Location:2075 → 2152
    IG_like; Immunoglobulin like
    cd00054
    Location:3870 → 3899
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1176 → 1225
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4221 → 4380
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:302 → 336
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4126 → 4156
    EGF; EGF-like domain
    pfam00052
    Location:1414 → 1546
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1293 → 1340
    Laminin_EGF; Laminin EGF domain
    pfam07679
    Location:3599 → 3676
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:3596 → 3599
    Ig; Ig strand A [structural motif]
    cd05754
    Location:1789 → 1874
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:3423 → 3501
    Ig; Immunoglobulin domain

  3. XM_038001360.1 → XP_037857288.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X4

    UniProtKB/TrEMBL
    A0A0D9S8B1
    Conserved Domains (16) summary
    cd05743
    Location:421 → 498
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00200
    Location:80 → 194
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:985 → 1112
    LamB; Laminin B domain
    smart00409
    Location:2057 → 2134
    IG; Immunoglobulin
    smart00410
    Location:2158 → 2235
    IG_like; Immunoglobulin like
    cd00054
    Location:3852 → 3881
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1158 → 1207
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4203 → 4362
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:285 → 319
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4108 → 4138
    EGF; EGF-like domain
    pfam00052
    Location:1396 → 1528
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1275 → 1322
    Laminin_EGF; Laminin EGF domain
    pfam07679
    Location:3581 → 3658
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:3578 → 3581
    Ig; Ig strand A [structural motif]
    cd05754
    Location:1771 → 1856
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:3405 → 3483
    Ig; Immunoglobulin domain

  4. XM_038001330.1 → XP_037857258.1  basement membrane-specific heparan sulfate proteoglycan core protein isoform X3

    UniProtKB/TrEMBL
    A0A0D9S8B1
    Conserved Domains (16) summary
    cd05743
    Location:421 → 498
    Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins
    smart00200
    Location:80 → 194
    SEA; Domain found in sea urchin sperm protein, enterokinase, agrin
    smart00281
    Location:986 → 1113
    LamB; Laminin B domain
    smart00409
    Location:2159 → 2236
    IG; Immunoglobulin
    smart00410
    Location:2058 → 2135
    IG_like; Immunoglobulin like
    cd00054
    Location:3853 → 3882
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00055
    Location:1159 → 1208
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:4204 → 4363
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    cd00112
    Location:285 → 319
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00008
    Location:4109 → 4139
    EGF; EGF-like domain
    pfam00052
    Location:1397 → 1529
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1276 → 1323
    Laminin_EGF; Laminin EGF domain
    pfam07679
    Location:3582 → 3659
    I-set; Immunoglobulin I-set domain
    cd00096
    Location:3579 → 3582
    Ig; Ig strand A [structural motif]
    cd05754
    Location:1772 → 1857
    IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains
    cl11960
    Location:3406 → 3484
    Ig; Immunoglobulin domain
Nucleotide Protein
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