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sos2 son of sevenless homolog 2 (Drosophila) [ Callorhinchus milii (elephant shark) ]

Gene ID: 103175274, updated on 11-Mar-2024

Summary

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Gene symbol
sos2
Gene description
son of sevenless homolog 2 (Drosophila)
See related
Ensembl:ENSCMIG00000013057
Gene type
protein coding
RefSeq status
MODEL
Organism
Callorhinchus milii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; Holocephali; Chimaeriformes; Callorhinchidae; Callorhinchus
Orthologs
human zebrafish all
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Genomic context

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See sos2 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
24
Annotation release Status Assembly Chr Location
101 current IMCB_Cmil_1.0 (GCF_018977255.1) Unplaced Scaffold NW_024704750.1 (7079396..7112700, complement)
100 previous assembly Callorhinchus_milii-6.1.3 (GCF_000165045.1) Unplaced Scaffold NW_006890062.1 (10022369..10048233)

NW_024704750.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103175275 Neighboring gene valosin containing protein lysine (K) methyltransferase Neighboring gene L-2-hydroxyglutarate dehydrogenase Neighboring gene distal membrane arm assembly component 2 like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Sequencing and analysis of full-length cDNAs, 5'-ESTs and 3'-ESTs from a cartilaginous fish, the elephant shark (Callorhinchus milii). Tan YY, et al. PLoS One, 2012. PMID 23056606, Free PMC Article
  2. Elephant shark genome provides unique insights into gnathostome evolution. Venkatesh B, et al. Nature, 2014 Jan 9. PMID 24402279, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ras protein signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
son of sevenless homolog 2
Names
SOS Ras/Rho guanine nucleotide exchange factor 2
son of sevenless-like 2-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Callorhinchus milii Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference IMCB_Cmil_1.0 Primary Assembly

Genomic

  1. NW_024704750.1 Reference IMCB_Cmil_1.0 Primary Assembly

    Range
    7079396..7112700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_042337968.1 → XP_042193902.1  son of sevenless homolog 2 isoform X2

    UniProtKB/TrEMBL
    A0A4W3JDL1, V9K7I7
    Conserved Domains (5) summary
    smart00147
    Location:772 → 1016
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:593 → 737
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00160
    Location:197 → 384
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:435 → 541
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:67 → 166
    Histone; Core histone H2A/H2B/H3/H4

  2. XM_042337967.1 → XP_042193901.1  son of sevenless homolog 2 isoform X1

    UniProtKB/TrEMBL
    A0A4W3JDX2, V9K7V4
    Conserved Domains (5) summary
    smart00147
    Location:772 → 1016
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:593 → 737
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00160
    Location:197 → 384
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
    cd01261
    Location:435 → 541
    PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
    pfam00125
    Location:67 → 166
    Histone; Core histone H2A/H2B/H3/H4
Nucleotide Protein
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